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Protein

Putative oxidoreductase GLYR1

Gene

glyr1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of mapk14 and specifically regulating mapk14 signaling (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei343 – 3431NADBy similarity
Binding sitei486 – 4861NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi144 – 15613A.T hookAdd
BLAST
Nucleotide bindingi252 – 26615NADBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

DNA-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative oxidoreductase GLYR1 (EC:1.-.-.-)
Alternative name(s):
Glyoxylate reductase 1 homolog
Nuclear protein NP60
Gene namesi
Name:glyr1
Synonyms:np60
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-958848. glyr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Putative oxidoreductase GLYR1PRO_0000312127Add
BLAST

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ562D5.
SMRiQ562D5. Positions 243-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 6659PWWPPROSITE-ProRule annotationAdd
BLAST

Domaini

The PWWP domain probably mediates the binding to H3K36me3.By similarity

Sequence similaritiesi

Contains 1 A.T hook DNA-binding domain.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000219609.
InParanoidiQ562D5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR000313. PWWP_dom.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q562D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSLRQGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CLFVKFFGTE
60 70 80 90 100
DHAWIKVEQL KPYHAHKEEM IKANKGKRFQ QAVDAVEEFL KKAKAKEHAK
110 120 130 140 150
EHNSSDEKGK KGEGKGKKQT GEKRRKSSES SSHSPQKRSR DQSPRKRGRP
160 170 180 190 200
PKDDKDSPSP QPSSLKKLAM KTVSRFSWPP PSTEDDLGSD SWLIHGHRTL
210 220 230 240 250
GTEMILKKPS VTYQAITKRL KISEEDSGST SIQAADSTAI NGNIIPTDKK
260 270 280 290 300
IGFLGLGLMG SGIVSNLLKM GHTVTVWNRT AEKCDLFIQE GAHMGRTPAE
310 320 330 340 350
VVSTCDITFA CVADPKAAKD LVLGPSGVLQ GIRPGKCYVD MSTVDPETVA
360 370 380 390 400
ELAQVIVSRG GRFLEAPVSG NQQLSNDGML VILAAGDQGV YEDCSSCFLA
410 420 430 440 450
MGKTSFFLGE VGNAARMMLI LNMVQGSFMA TIAEGMTLAQ VTGQSQQTLL
460 470 480 490 500
DILNQGQLAS IFLDQKCQNI LQGNFKPDFY LKYIQKDLRL AIALGDSVNH
510 520 530
PTPMAAAANE VYKRAKALDQ SDNDMSAVYR AYIH
Length:534
Mass (Da):58,475
Last modified:May 10, 2005 - v1
Checksum:i69D3609740288A51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092548 mRNA. Translation: AAH92548.1.
RefSeqiNP_001025665.1. NM_001030494.1.
UniGeneiStr.55546.

Genome annotation databases

GeneIDi595057.
KEGGixtr:595057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092548 mRNA. Translation: AAH92548.1.
RefSeqiNP_001025665.1. NM_001030494.1.
UniGeneiStr.55546.

3D structure databases

ProteinModelPortaliQ562D5.
SMRiQ562D5. Positions 243-534.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi595057.
KEGGixtr:595057.

Organism-specific databases

CTDi84656.
XenbaseiXB-GENE-958848. glyr1.

Phylogenomic databases

HOGENOMiHOG000219609.
InParanoidiQ562D5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR000313. PWWP_dom.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGLYR1_XENTR
AccessioniPrimary (citable) accession number: Q562D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.