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Protein

Leucine zipper transcription factor-like protein 1

Gene

Lztfl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5620922. BBSome-mediated cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper transcription factor-like protein 1
Gene namesi
Name:Lztfl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306628. Lztfl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Leucine zipper transcription factor-like protein 1PRO_0000318762Add
BLAST

Proteomic databases

PaxDbiQ562C6.
PRIDEiQ562C6.

PTM databases

iPTMnetiQ562C6.

Expressioni

Gene expression databases

GenevisibleiQ562C6. RN.

Interactioni

Subunit structurei

Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008254.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 299155Interaction with BSS9By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 299155Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the LZTFL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGWZ. Eukaryota.
ENOG410ZUNH. LUCA.
GeneTreeiENSGT00390000016415.
HOGENOMiHOG000067838.
HOVERGENiHBG054284.
InParanoidiQ562C6.
KOiK19400.
OMAiGFNEHHQ.
OrthoDBiEOG7ZWD2H.
PhylomeDBiQ562C6.
TreeFamiTF329023.

Family and domain databases

InterProiIPR026157. LZTFL1.
[Graphical view]
PANTHERiPTHR21635. PTHR21635. 1 hit.

Sequencei

Sequence statusi: Complete.

Q562C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEETFT
60 70 80 90 100
IDEVSEVLNG LQAVVHSEVE SELINTAHTN VLLLRQLFSQ AEKWYLKLQT
110 120 130 140 150
DVSELENREL LEQVAEFEKA EFASSNKKPI IDITKPKLVP INEGGTTELL
160 170 180 190 200
NKEILRLQQE NEKLKSRLKT IETQAVNALD EKSKLERVLQ DLQLDQGNQQ
210 220 230 240 250
DFIKAQDLDD LENTVAALKS EFQKTLNDKT ENQKSLEENL AAAKHDLLRV
260 270 280 290
QEQLSMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAKYESED
Length:299
Mass (Da):34,638
Last modified:May 10, 2005 - v1
Checksum:i282E5A663C92F413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092585 mRNA. Translation: AAH92585.1.
RefSeqiNP_001019437.1. NM_001024266.1.
XP_006244253.1. XM_006244191.1.
UniGeneiRn.25212.

Genome annotation databases

EnsembliENSRNOT00000008255; ENSRNOP00000008254; ENSRNOG00000006244.
ENSRNOT00000091431; ENSRNOP00000071325; ENSRNOG00000006244.
GeneIDi316102.
KEGGirno:316102.
UCSCiRGD:1306628. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092585 mRNA. Translation: AAH92585.1.
RefSeqiNP_001019437.1. NM_001024266.1.
XP_006244253.1. XM_006244191.1.
UniGeneiRn.25212.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008254.

PTM databases

iPTMnetiQ562C6.

Proteomic databases

PaxDbiQ562C6.
PRIDEiQ562C6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008255; ENSRNOP00000008254; ENSRNOG00000006244.
ENSRNOT00000091431; ENSRNOP00000071325; ENSRNOG00000006244.
GeneIDi316102.
KEGGirno:316102.
UCSCiRGD:1306628. rat.

Organism-specific databases

CTDi54585.
RGDi1306628. Lztfl1.

Phylogenomic databases

eggNOGiENOG410IGWZ. Eukaryota.
ENOG410ZUNH. LUCA.
GeneTreeiENSGT00390000016415.
HOGENOMiHOG000067838.
HOVERGENiHBG054284.
InParanoidiQ562C6.
KOiK19400.
OMAiGFNEHHQ.
OrthoDBiEOG7ZWD2H.
PhylomeDBiQ562C6.
TreeFamiTF329023.

Enzyme and pathway databases

ReactomeiR-RNO-5620922. BBSome-mediated cargo-targeting to cilium.

Miscellaneous databases

NextBioi670441.
PROiQ562C6.

Gene expression databases

GenevisibleiQ562C6. RN.

Family and domain databases

InterProiIPR026157. LZTFL1.
[Graphical view]
PANTHERiPTHR21635. PTHR21635. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiLZTL1_RAT
AccessioniPrimary (citable) accession number: Q562C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: January 20, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.