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Protein

Leucine zipper transcription factor-like protein 1

Gene

Lztfl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5620922 BBSome-mediated cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper transcription factor-like protein 1
Gene namesi
Name:Lztfl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1306628 Lztfl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003187621 – 299Leucine zipper transcription factor-like protein 1Add BLAST299

Proteomic databases

PaxDbiQ562C6
PRIDEiQ562C6

PTM databases

iPTMnetiQ562C6
PhosphoSitePlusiQ562C6

Expressioni

Gene expression databases

BgeeiENSRNOG00000006244
GenevisibleiQ562C6 RN

Interactioni

Subunit structurei

Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008254

Structurei

3D structure databases

SMRiQ562C6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 299Interaction with BSS9By similarityAdd BLAST155

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 299Sequence analysisAdd BLAST155

Sequence similaritiesi

Belongs to the LZTFL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGWZ Eukaryota
ENOG410ZUNH LUCA
GeneTreeiENSGT00390000016415
HOGENOMiHOG000067838
HOVERGENiHBG054284
InParanoidiQ562C6
KOiK19400
OMAiMQDAMND
PhylomeDBiQ562C6
TreeFamiTF329023

Family and domain databases

InterProiView protein in InterPro
IPR026157 LZTFL1
PANTHERiPTHR21635 PTHR21635, 1 hit
PfamiView protein in Pfam
PF15294 Leu_zip, 1 hit

Sequencei

Sequence statusi: Complete.

Q562C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEETFT
60 70 80 90 100
IDEVSEVLNG LQAVVHSEVE SELINTAHTN VLLLRQLFSQ AEKWYLKLQT
110 120 130 140 150
DVSELENREL LEQVAEFEKA EFASSNKKPI IDITKPKLVP INEGGTTELL
160 170 180 190 200
NKEILRLQQE NEKLKSRLKT IETQAVNALD EKSKLERVLQ DLQLDQGNQQ
210 220 230 240 250
DFIKAQDLDD LENTVAALKS EFQKTLNDKT ENQKSLEENL AAAKHDLLRV
260 270 280 290
QEQLSMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAKYESED
Length:299
Mass (Da):34,638
Last modified:May 10, 2005 - v1
Checksum:i282E5A663C92F413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092585 mRNA Translation: AAH92585.1
RefSeqiNP_001019437.1, NM_001024266.1
XP_006244253.1, XM_006244191.1
UniGeneiRn.25212

Genome annotation databases

EnsembliENSRNOT00000008255; ENSRNOP00000008254; ENSRNOG00000006244
ENSRNOT00000091431; ENSRNOP00000071325; ENSRNOG00000006244
GeneIDi316102
KEGGirno:316102
UCSCiRGD:1306628 rat

Similar proteinsi

Entry informationi

Entry nameiLZTL1_RAT
AccessioniPrimary (citable) accession number: Q562C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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