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Protein

Ribosome biogenesis protein BOP1

Gene

Bop1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BOP1UniRule annotation
Alternative name(s):
Block of proliferation 1 proteinUniRule annotation
Gene namesi
Name:Bop1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1310589. Bop1.

Subcellular locationi

  • Nucleusnucleolus UniRule annotation
  • Nucleusnucleoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003703861 – 731Ribosome biogenesis protein BOP1Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphotyrosineBy similarity1
Modified residuei111PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ562C2.
PRIDEiQ562C2.

PTM databases

iPTMnetiQ562C2.
PhosphoSitePlusiQ562C2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021773.
GenevisibleiQ562C2. RN.

Interactioni

Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025133.

Structurei

3D structure databases

ProteinModelPortaliQ562C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati396 – 435WD 1Add BLAST40
Repeati437 – 477WD 2Add BLAST41
Repeati517 – 559WD 3Add BLAST43
Repeati562 – 600WD 4Add BLAST39
Repeati603 – 642WD 5Add BLAST40
Repeati646 – 685WD 6Add BLAST40
Repeati701 – 731WD 7Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni250 – 412Sufficient for nucleolar localizationBy similarityAdd BLAST163

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
InParanoidiQ562C2.
KOiK14824.
OMAiLEWYADF.
OrthoDBiEOG091G0389.
PhylomeDBiQ562C2.
TreeFamiTF300437.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03027. BOP1. 1 hit.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q562C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGACGKHHM SPGSLPGKRR LEPDQEPQIQ EPLLLSDPDS SLSDSEESVF
60 70 80 90 100
SGLEDSGSDT SDEDTEEVAR AGCDKDNRTE KTSEEQEQAV PPCPRAEEAG
110 120 130 140 150
ALTRDEYEED SSDEEDIRNT VGNVPLAWYD DFPHVGYDLD GKRIYKPLRT
160 170 180 190 200
RDELDQFLDK MDDPDFWRTV QDKMTGSDLR LTDEQVALVH RLQRGQFGDS
210 220 230 240 250
GFDPYEPAVD FFSGDIMIHP VTNRPADKRS FIPSLVEKEK VSRLVHAIKM
260 270 280 290 300
GWIKPRRPPD STPSFYDLWA QEDPNAVLGR HKMHVPAPKL ALPGHAESYN
310 320 330 340 350
PPPEYLPTEE ERLAWMQQEP IERKLNFLPQ KFPSLRTVPA YGRFIQERFE
360 370 380 390 400
RCLDLYLCPR QRKMRVNVDP EDLIPKLPRP RDLQPFPVCQ ALVYRGHSDL
410 420 430 440 450
VRCLSVSPGG QWLASGSDDG TLRLWEVATA RCMKTVRVGG VIRSIAWNPN
460 470 480 490 500
PTICLVAAAM DDAVVLLNPA LGDRLLVGST DQLLETFTPP EEPTLQPAHW
510 520 530 540 550
LEVSEEERQR GLRLRICHSK PVTQVTWHGR GDYLAVVLSS QGHTQVLIHQ
560 570 580 590 600
LSRRRSQSPF RRSHGQVQCV AFHPTRPFLL VASQRSIRIY HLLRQELTKK
610 620 630 640 650
LMPNCKWVSS MAVHPAGDNI ICGSYDSKLV WFDLDLSTKP YKVLRHHKKA
660 670 680 690 700
LRAVAFHPRY PLFASGSDDG SVIVCHGMVY NDLLQNPLLV PVKVLKGHSL
710 720 730
TRDLGVLDVA FHPTQPWVFS SGADGTIRLF S
Length:731
Mass (Da):82,640
Last modified:May 10, 2005 - v1
Checksum:i0CAAB45CF7A2FF63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092594 mRNA. Translation: AAH92594.1.
RefSeqiNP_001019421.1. NM_001024250.1.
UniGeneiRn.101388.

Genome annotation databases

EnsembliENSRNOT00000025134; ENSRNOP00000025133; ENSRNOG00000021773.
GeneIDi300050.
KEGGirno:300050.
UCSCiRGD:1310589. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092594 mRNA. Translation: AAH92594.1.
RefSeqiNP_001019421.1. NM_001024250.1.
UniGeneiRn.101388.

3D structure databases

ProteinModelPortaliQ562C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025133.

PTM databases

iPTMnetiQ562C2.
PhosphoSitePlusiQ562C2.

Proteomic databases

PaxDbiQ562C2.
PRIDEiQ562C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025134; ENSRNOP00000025133; ENSRNOG00000021773.
GeneIDi300050.
KEGGirno:300050.
UCSCiRGD:1310589. rat.

Organism-specific databases

CTDi23246.
RGDi1310589. Bop1.

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
InParanoidiQ562C2.
KOiK14824.
OMAiLEWYADF.
OrthoDBiEOG091G0389.
PhylomeDBiQ562C2.
TreeFamiTF300437.

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ562C2.

Gene expression databases

BgeeiENSRNOG00000021773.
GenevisibleiQ562C2. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03027. BOP1. 1 hit.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBOP1_RAT
AccessioniPrimary (citable) accession number: Q562C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.