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Protein

Ribosome biogenesis protein BOP1

Gene

Bop1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BOP1UniRule annotation
Alternative name(s):
Block of proliferation 1 proteinUniRule annotation
Gene namesi
Name:Bop1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1310589. Bop1.

Subcellular locationi

  • Nucleusnucleolus UniRule annotation
  • Nucleusnucleoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Ribosome biogenesis protein BOP1PRO_0000370386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071PhosphotyrosineBy similarity
Modified residuei111 – 1111PhosphoserineCombined sources
Modified residuei112 – 1121PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ562C2.
PRIDEiQ562C2.

PTM databases

iPTMnetiQ562C2.
PhosphoSiteiQ562C2.

Expressioni

Gene expression databases

GenevisibleiQ562C2. RN.

Interactioni

Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025133.

Structurei

3D structure databases

ProteinModelPortaliQ562C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati396 – 43540WD 1Add
BLAST
Repeati437 – 47741WD 2Add
BLAST
Repeati517 – 55943WD 3Add
BLAST
Repeati562 – 60039WD 4Add
BLAST
Repeati603 – 64240WD 5Add
BLAST
Repeati646 – 68540WD 6Add
BLAST
Repeati701 – 73131WD 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 412163Sufficient for nucleolar localizationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
InParanoidiQ562C2.
KOiK14824.
OMAiIWEISST.
OrthoDBiEOG7MPRD9.
PhylomeDBiQ562C2.
TreeFamiTF300437.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03027. BOP1.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q562C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGACGKHHM SPGSLPGKRR LEPDQEPQIQ EPLLLSDPDS SLSDSEESVF
60 70 80 90 100
SGLEDSGSDT SDEDTEEVAR AGCDKDNRTE KTSEEQEQAV PPCPRAEEAG
110 120 130 140 150
ALTRDEYEED SSDEEDIRNT VGNVPLAWYD DFPHVGYDLD GKRIYKPLRT
160 170 180 190 200
RDELDQFLDK MDDPDFWRTV QDKMTGSDLR LTDEQVALVH RLQRGQFGDS
210 220 230 240 250
GFDPYEPAVD FFSGDIMIHP VTNRPADKRS FIPSLVEKEK VSRLVHAIKM
260 270 280 290 300
GWIKPRRPPD STPSFYDLWA QEDPNAVLGR HKMHVPAPKL ALPGHAESYN
310 320 330 340 350
PPPEYLPTEE ERLAWMQQEP IERKLNFLPQ KFPSLRTVPA YGRFIQERFE
360 370 380 390 400
RCLDLYLCPR QRKMRVNVDP EDLIPKLPRP RDLQPFPVCQ ALVYRGHSDL
410 420 430 440 450
VRCLSVSPGG QWLASGSDDG TLRLWEVATA RCMKTVRVGG VIRSIAWNPN
460 470 480 490 500
PTICLVAAAM DDAVVLLNPA LGDRLLVGST DQLLETFTPP EEPTLQPAHW
510 520 530 540 550
LEVSEEERQR GLRLRICHSK PVTQVTWHGR GDYLAVVLSS QGHTQVLIHQ
560 570 580 590 600
LSRRRSQSPF RRSHGQVQCV AFHPTRPFLL VASQRSIRIY HLLRQELTKK
610 620 630 640 650
LMPNCKWVSS MAVHPAGDNI ICGSYDSKLV WFDLDLSTKP YKVLRHHKKA
660 670 680 690 700
LRAVAFHPRY PLFASGSDDG SVIVCHGMVY NDLLQNPLLV PVKVLKGHSL
710 720 730
TRDLGVLDVA FHPTQPWVFS SGADGTIRLF S
Length:731
Mass (Da):82,640
Last modified:May 10, 2005 - v1
Checksum:i0CAAB45CF7A2FF63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092594 mRNA. Translation: AAH92594.1.
RefSeqiNP_001019421.1. NM_001024250.1.
UniGeneiRn.101388.

Genome annotation databases

EnsembliENSRNOT00000025134; ENSRNOP00000025133; ENSRNOG00000021773.
GeneIDi300050.
KEGGirno:300050.
UCSCiRGD:1310589. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092594 mRNA. Translation: AAH92594.1.
RefSeqiNP_001019421.1. NM_001024250.1.
UniGeneiRn.101388.

3D structure databases

ProteinModelPortaliQ562C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025133.

PTM databases

iPTMnetiQ562C2.
PhosphoSiteiQ562C2.

Proteomic databases

PaxDbiQ562C2.
PRIDEiQ562C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025134; ENSRNOP00000025133; ENSRNOG00000021773.
GeneIDi300050.
KEGGirno:300050.
UCSCiRGD:1310589. rat.

Organism-specific databases

CTDi23246.
RGDi1310589. Bop1.

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
InParanoidiQ562C2.
KOiK14824.
OMAiIWEISST.
OrthoDBiEOG7MPRD9.
PhylomeDBiQ562C2.
TreeFamiTF300437.

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ562C2.

Gene expression databases

GenevisibleiQ562C2. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03027. BOP1.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111 AND SER-112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBOP1_RAT
AccessioniPrimary (citable) accession number: Q562C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 10, 2005
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.