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Q56275

- GLMS_ACIFR

UniProt

Q56275 - GLMS_ACIFR

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS
Organism
Acidithiobacillus ferrooxidans (Thiobacillus ferrooxidans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei606 – 6061For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
OrganismiAcidithiobacillus ferrooxidans (Thiobacillus ferrooxidans)
Taxonomic identifieri920 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 611610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135404Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ56275.
SMRiQ56275. Positions 2-611.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2
Add
BLAST
Domaini287 – 427141SIS 1
Add
BLAST
Domaini460 – 601142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56275-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGGVSK TDLVPMILEG LQRLEYRGYD SAGLAILGAD ADLLRVRSVG    50
RVAELTAAVV ERGLQGQVGI GHTRWATHGG VRECNAHPMI SHEQIAVVHN 100
GIIENFHALR AHLEAAGYTF TSETDTEVIA HLVHHYRQTA PDLFAATRRA 150
VGDLRGAYAI AVISSGDPET VCVARMGCPL LLGVADDGHY FASDVAALLP 200
VTRRVLYLED GDVAMLQRQT LRITDQAGAS RQREEHWSQL SAAAVDLGPY 250
RHFMQKEIHE QPRAVADTLE GALNSQLDLT DLWGDGAAAM FRDVDRVLFL 300
ASGTSHYATL VGRQWVESIV GIPAQAELGH EYRYRDSIPD PRQLVVTLSQ 350
SGETLDTFEA LRRAKDLGHT RTLAICNVAE SAIPRASALR FLTRAGPEIG 400
VASTKAFTTQ LAALYLLALS LAKAPGASER CAAGGSPGRL RQLPGSVQHA 450
LNLEPQIQGW AARFASKDHA LFLGRGLHYP IALEGALKLK EISYIHAEAY 500
PAGELKHGPL ALVDRDMPVV VIAPNDRLLE KLAANMQEVH ARGGELYVFA 550
DSDSHFNASA GVHVMRLPRH AGLLSPIVHA IPVQLLAYHA ALVKGTDVDR 600
PRNLAKSVTV E 611
Length:611
Mass (Da):65,993
Last modified:January 23, 2007 - v3
Checksum:iC03B2C3A20A0A512
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF032884 Genomic DNA. Translation: AAC21670.1.
PIRiT45493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF032884 Genomic DNA. Translation: AAC21670.1 .
PIRi T45493.

3D structure databases

ProteinModelPortali Q56275.
SMRi Q56275. Positions 2-611.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sarnovsky R.J., Craig N.L., Oppon J.C., Rawlings D.E.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33020 / 11Fe.

Entry informationi

Entry nameiGLMS_ACIFR
AccessioniPrimary (citable) accession number: Q56275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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