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Q56254

- RPOM_THECE

UniProt

Q56254 - RPOM_THECE

Protein

DNA-directed RNA polymerase subunit M

Gene

rpoM

Organism
Thermococcus celer
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2522C4-typeSequence AnalysisAdd
    BLAST
    Zinc fingeri67 – 10741TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit M (EC:2.7.7.6)
    Gene namesi
    Name:rpoM
    OrganismiThermococcus celer
    Taxonomic identifieri2264 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 110110DNA-directed RNA polymerase subunit MPRO_0000121483Add
    BLAST

    Structurei

    Secondary structure

    1
    110
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi62 – 643
    Beta strandi66 – 683
    Turni72 – 743
    Beta strandi77 – 848
    Beta strandi87 – 904
    Beta strandi92 – 10211
    Beta strandi105 – 1073

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QYPNMR-A58-110[»]
    ProteinModelPortaliQ56254.
    SMRiQ56254. Positions 57-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ56254.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 TFIIS-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2522C4-typeSequence AnalysisAdd
    BLAST
    Zinc fingeri67 – 10741TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    InterProiIPR019761. DNA-dir_RNA_pol-M_15_CS.
    IPR001529. DNA-dir_RNA_pol_M/15kDasu.
    IPR012164. DNA-dir_RNApol_C11.
    IPR006288. TFS/rpoM.
    IPR001222. Znf_TFIIS.
    [Graphical view]
    PfamiPF02150. RNA_POL_M_15KD. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005586. RNApol_RpoM. 1 hit.
    SMARTiSM00661. RPOL9. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01384. TFS_arch. 1 hit.
    PROSITEiPS01030. RNA_POL_M_15KD. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q56254-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFCPKCGNL MLPDRKRKVW VCRSCGYEEP FDEEKDREKT VIKQEVKHKP    50
    DEGIVVIEQD LKTLPTTKIT CPKCGNDTAY WWEMQTRAGD EPSTIFYKCT 100
    KCGHTWRSYE 110
    Length:110
    Mass (Da):12,970
    Last modified:November 1, 1996 - v1
    Checksum:i3AE99D6905FD4E4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27650 Unassigned DNA. Translation: AAA72052.1.
    PIRiA55263.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27650 Unassigned DNA. Translation: AAA72052.1 .
    PIRi A55263.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QYP NMR - A 58-110 [» ]
    ProteinModelPortali Q56254.
    SMRi Q56254. Positions 57-110.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q56254.

    Family and domain databases

    InterProi IPR019761. DNA-dir_RNA_pol-M_15_CS.
    IPR001529. DNA-dir_RNA_pol_M/15kDasu.
    IPR012164. DNA-dir_RNApol_C11.
    IPR006288. TFS/rpoM.
    IPR001222. Znf_TFIIS.
    [Graphical view ]
    Pfami PF02150. RNA_POL_M_15KD. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005586. RNApol_RpoM. 1 hit.
    SMARTi SM00661. RPOL9. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01384. TFS_arch. 1 hit.
    PROSITEi PS01030. RNA_POL_M_15KD. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence, and its evolutionary implications, of a Thermococcus celer protein associated with transcription."
      Kaine B.P., Mehr I.J., Woese C.R.
      Proc. Natl. Acad. Sci. U.S.A. 91:3854-3856(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "High-resolution structure of an archaeal zinc ribbon defines a general architectural motif in eukaryotic RNA polymerases."
      Wang B., Jones D.N.M., Kaine B.P., Weiss M.A.
      Structure 6:555-569(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 54-110.

    Entry informationi

    Entry nameiRPOM_THECE
    AccessioniPrimary (citable) accession number: Q56254
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3