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Reviewed, UniProtKB/Swiss-Prot Q56239 (MUTS_THET8)

Last modified February 9, 2010. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    DNA mismatch repair protein mutS
Gene names
Name: mutS
Ordered Locus Names: TTHA1324
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Complete proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

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Protein attributes

Sequence length819 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. Binds double-stranded DNA. HAMAP MF_00096

Subunit structure

Homotetramer. HAMAP MF_00096

Sequence similarities

Belongs to the DNA mismatch repair mutS family.

Biophysicochemical properties

Temperature dependence:

Optimum temperature is 80 degrees Celsius for ATPase activity. HAMAP MF_00096

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 819818DNA mismatch repair protein mutS HAMAP MF_00096
PRO_0000115160

Regions

Nucleotide binding591 – 5988ATP Potential
Region2 – 130129A1 HAMAP MF_00096
Region131 – 274144A2 HAMAP MF_00096
Region275 – 570296B; DNA-binding HAMAP MF_00096
Region571 – 819249C HAMAP MF_00096

Experimental info

Sequence conflict7891D → N AA sequence Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q56239-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: DC033E736879863E

FASTA81991,381
        10         20         30         40         50         60 
MGGYGGVKME GMLKGEGPGP LPPLLQQYVE LRDRYPDYLL LFQVGDFYEC FGEDAERLAR 

        70         80         90        100        110        120 
ALGLVLTHKT SKDFTTPMAG IPIRAFDAYA ERLLKMGFRL AVADQVEPAE EAEGLVRREV 

       130        140        150        160        170        180 
TQLLTPGTLT QEALLPREAN YLAAIATGDG WGLAFLDVST GEFKGTLLKS KSALYDELFR 

       190        200        210        220        230        240 
HRPAEVLLAP ELRENEAFVA EFRKRFPVML SEAPFEPQGE GPLALRRAQG ALLAYARATQ 

       250        260        270        280        290        300 
GGALSVRPFR LYDPGAFVRL PEASLKALEV FEPLRGQDTL FGVLDETRTA PGRRLLQAWL 

       310        320        330        340        350        360 
RHPLLERGPL EARLDRVERF VREGALREGV RRLLFRLADL ERLATRLELS RASPRDLAAL 

       370        380        390        400        410        420 
RRSLEILPEL KGLLGEEVGL PDLSGLLEEL RAALVEDPPL KVSEGGLIRE GYDPDLDALR 

       430        440        450        460        470        480 
RAHAEGVAYF LDLEAREKER TGIPTLKVGY NAVFGYYLEV TRPYYEKVPQ EYRPVQTLKD 

       490        500        510        520        530        540 
RQRYTLPEMK ERERELYRLE ALIKRREEEV FLALRERARK EAEALREAAR ILAELDVYAA 

       550        560        570        580        590        600 
LAEVAVRHGY TRPRFGERLR IRAGRHPVVE RRTAFVPNDL EMAHELVLVT GPNMAGKSTF 

       610        620        630        640        650        660 
LRQTALIALL AQIGSFVPAE EAELPLFDGI YTRIGASDDL AGGKSTFMVE MEEVALVLKE 

       670        680        690        700        710        720 
ATERSLVLLD EVGRGTSSLD GVAIATALAE ALHERRCYTL FATHYFELTA LALPRLKNLH 

       730        740        750        760        770        780 
VAAKEEEGGL VFYHQVLPGP ASKSYGVEVA EMAGLPKEVV ERARALLSAM AARREGALEE 

       790        800        810 
VLERLLALDP DRLTPLEALR FLHELKALAL GLPLGSMKG

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References

« Hide 'large scale' references
[1]"Mismatch DNA recognition protein from an extremely thermophilic bacterium, Thermus thermophilus HB8."
Takamatsu S., Kato R., Kuramitsu S.
Nucleic Acids Res. 24:640-647(1996) [PubMed: 8604304] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-21, CHARACTERIZATION.
[2]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Domain organization and functional analysis of Thermus thermophilus MutS protein."
Tachiki H., Kato R., Masui R., Hasegawa K., Itakura H., Fukuyama K., Kuramitsu S.
Nucleic Acids Res. 26:4153-4159(1998) [PubMed: 9722634] [Abstract]
Cited for: DOMAIN STRUCTURE.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D63810 Genomic DNA. Translation: BAA09880.1.
AP008226 Genomic DNA. Translation: BAD71147.1.
RefSeqYP_144590.1.

3D structure databases

SMRQ56239. Positions 9-773.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ56239.

Genome annotation databases

GeneID3168860.
GenomeReviewsGene locus TTHA1324 in contig AP008226_GR.
KEGGttj:TTHA1324.
NMPDRfig|300852.3.peg.1577.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHBG735169.
OMADFFECFF.

Enzyme and pathway databases

BioCycTTHE300852:TTHA1324-MONOMER.

Family and domain databases

HAMAPMF_00096. MutS.
[Tree]
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007860. DNA_mismatch_repair_MutS_connt.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
[Graphical view]
Gene3DG3DSA:3.30.420.110. DNA_mismatch_repair_MutS_connt. 1 hit.
G3DSA:3.40.1170.10. DNA_mismatch_repair_MutS_N. 1 hit.
PANTHERPTHR11361. MutS_C. 1 hit.
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMUTS_THET8
AccessionPrimary (citable) accession number: Q56239
Secondary accession number(s): Q5SIP5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents