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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

pyridoxal 5'-phosphate1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Aspartate; via amide nitrogenBy similarity
Binding sitei125 – 1251Aspartate
Binding sitei175 – 1751Aspartate
Binding sitei361 – 3611Aspartate

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-49-MONOMER.
BRENDAi2.6.1.1. 2305.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:TTHA0046
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Aspartate aminotransferasePRO_0000123856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341N6-(pyridoxal phosphate)lysine

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi300852.TTHA0046.

Structurei

Secondary structure

1
385
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 105Combined sources
Helixi15 – 2814Combined sources
Helixi47 – 5812Combined sources
Helixi71 – 8313Combined sources
Helixi91 – 933Combined sources
Beta strandi94 – 985Combined sources
Helixi99 – 11113Combined sources
Beta strandi117 – 1237Combined sources
Helixi127 – 1348Combined sources
Beta strandi138 – 1436Combined sources
Helixi146 – 1483Combined sources
Helixi154 – 1585Combined sources
Beta strandi165 – 1739Combined sources
Turni175 – 1773Combined sources
Helixi183 – 19513Combined sources
Beta strandi199 – 2035Combined sources
Turni205 – 2084Combined sources
Beta strandi210 – 2134Combined sources
Helixi218 – 2203Combined sources
Turni223 – 2253Combined sources
Beta strandi226 – 2327Combined sources
Turni233 – 2375Combined sources
Helixi239 – 2413Combined sources
Beta strandi244 – 2474Combined sources
Helixi250 – 26112Combined sources
Turni262 – 2643Combined sources
Beta strandi265 – 2673Combined sources
Helixi269 – 28012Combined sources
Helixi282 – 31029Combined sources
Beta strandi318 – 3269Combined sources
Turni328 – 3303Combined sources
Helixi334 – 34310Combined sources
Beta strandi349 – 3513Combined sources
Helixi352 – 3543Combined sources
Beta strandi359 – 3635Combined sources
Helixi368 – 37710Combined sources
Helixi378 – 3814Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B5OX-ray2.20A/B1-385[»]
1B5PX-ray1.80A/B1-385[»]
1BJWX-ray1.80A/B1-382[»]
1BKGX-ray2.60A/B/C/D1-385[»]
1GC3X-ray3.30A/B/C/D/E/F/G/H1-385[»]
1GC4X-ray3.30A/B/C/D1-385[»]
1GCKX-ray2.50A/B1-385[»]
5BJ3X-ray2.20A/B/C/D1-385[»]
5BJ4X-ray2.00A/B1-385[»]
ProteinModelPortaliQ56232.
SMRiQ56232. Positions 1-382.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56232.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223062.
KOiK00812.
OMAiYIWVDIS.
PhylomeDBiQ56232.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLSRRVQA MKPSATVAVN AKALELRRQG VDLVALTAGE PDFDTPEHVK
60 70 80 90 100
EAARRALAQG KTKYAPPAGI PELREALAEK FRRENGLSVT PEETIVTVGG
110 120 130 140 150
KQALFNLFQA ILDPGDEVIV LSPYWVSYPE MVRFAGGVVV EVETLPEEGF
160 170 180 190 200
VPDPERVRRA ITPRTKALVV NSPNNPTGAV YPKEVLEALA RLAVEHDFYL
210 220 230 240 250
VSDEIYEHLL YEGEHFSPGR VAPEHTLTVN GAAKAFAMTG WRIGYACGPK
260 270 280 290 300
EVIKAMASVS SQSTTSPDTI AQWATLEALT NQEASRAFVE MAREAYRRRR
310 320 330 340 350
DLLLEGLTAL GLKAVRPSGA FYVLMDTSPI APDEVRAAER LLEAGVAVVP
360 370 380
GTDFAAFGHV RLSYATSEEN LRKALERFAR VLGRA
Length:385
Mass (Da):42,051
Last modified:November 1, 1996 - v1
Checksum:iEADF7B7EA127F39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38459 Genomic DNA. Translation: BAA07487.1.
AP008226 Genomic DNA. Translation: BAD69869.1.
RefSeqiWP_011227669.1. NC_006461.1.
YP_143312.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD69869; BAD69869; BAD69869.
GeneIDi3168657.
KEGGittj:TTHA0046.
PATRICi23955021. VBITheThe93045_0044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38459 Genomic DNA. Translation: BAA07487.1.
AP008226 Genomic DNA. Translation: BAD69869.1.
RefSeqiWP_011227669.1. NC_006461.1.
YP_143312.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B5OX-ray2.20A/B1-385[»]
1B5PX-ray1.80A/B1-385[»]
1BJWX-ray1.80A/B1-382[»]
1BKGX-ray2.60A/B/C/D1-385[»]
1GC3X-ray3.30A/B/C/D/E/F/G/H1-385[»]
1GC4X-ray3.30A/B/C/D1-385[»]
1GCKX-ray2.50A/B1-385[»]
5BJ3X-ray2.20A/B/C/D1-385[»]
5BJ4X-ray2.00A/B1-385[»]
ProteinModelPortaliQ56232.
SMRiQ56232. Positions 1-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD69869; BAD69869; BAD69869.
GeneIDi3168657.
KEGGittj:TTHA0046.
PATRICi23955021. VBITheThe93045_0044.

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223062.
KOiK00812.
OMAiYIWVDIS.
PhylomeDBiQ56232.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-49-MONOMER.
BRENDAi2.6.1.1. 2305.

Miscellaneous databases

EvolutionaryTraceiQ56232.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAT_THET8
AccessioniPrimary (citable) accession number: Q56232
Secondary accession number(s): Q5SM97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.