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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

pyridoxal 5'-phosphate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39Aspartate; via amide nitrogenBy similarity1
Binding sitei125Aspartate1
Binding sitei175Aspartate1
Binding sitei361Aspartate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.1. 2305.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:TTHA0046
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238561 – 385Aspartate aminotransferaseAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234N6-(pyridoxal phosphate)lysine1

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi300852.TTHA0046.

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 10Combined sources5
Helixi15 – 28Combined sources14
Helixi47 – 58Combined sources12
Helixi71 – 83Combined sources13
Helixi91 – 93Combined sources3
Beta strandi94 – 98Combined sources5
Helixi99 – 111Combined sources13
Beta strandi117 – 123Combined sources7
Helixi127 – 134Combined sources8
Beta strandi138 – 143Combined sources6
Helixi146 – 148Combined sources3
Helixi154 – 158Combined sources5
Beta strandi165 – 173Combined sources9
Turni175 – 177Combined sources3
Helixi183 – 195Combined sources13
Beta strandi199 – 203Combined sources5
Turni205 – 208Combined sources4
Beta strandi210 – 213Combined sources4
Helixi218 – 220Combined sources3
Turni223 – 225Combined sources3
Beta strandi226 – 232Combined sources7
Turni233 – 237Combined sources5
Helixi239 – 241Combined sources3
Beta strandi244 – 247Combined sources4
Helixi250 – 261Combined sources12
Turni262 – 264Combined sources3
Beta strandi265 – 267Combined sources3
Helixi269 – 280Combined sources12
Helixi282 – 310Combined sources29
Beta strandi318 – 326Combined sources9
Turni328 – 330Combined sources3
Helixi334 – 343Combined sources10
Beta strandi349 – 351Combined sources3
Helixi352 – 354Combined sources3
Beta strandi359 – 363Combined sources5
Helixi368 – 377Combined sources10
Helixi378 – 381Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B5OX-ray2.20A/B1-385[»]
1B5PX-ray1.80A/B1-385[»]
1BJWX-ray1.80A/B1-382[»]
1BKGX-ray2.60A/B/C/D1-385[»]
1GC3X-ray3.30A/B/C/D/E/F/G/H1-385[»]
1GC4X-ray3.30A/B/C/D1-385[»]
1GCKX-ray2.50A/B1-385[»]
5BJ3X-ray2.20A/B/C/D1-385[»]
5BJ4X-ray2.00A/B1-385[»]
ProteinModelPortaliQ56232.
SMRiQ56232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56232.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223062.
KOiK00812.
OMAiYIWVDIS.
PhylomeDBiQ56232.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLSRRVQA MKPSATVAVN AKALELRRQG VDLVALTAGE PDFDTPEHVK
60 70 80 90 100
EAARRALAQG KTKYAPPAGI PELREALAEK FRRENGLSVT PEETIVTVGG
110 120 130 140 150
KQALFNLFQA ILDPGDEVIV LSPYWVSYPE MVRFAGGVVV EVETLPEEGF
160 170 180 190 200
VPDPERVRRA ITPRTKALVV NSPNNPTGAV YPKEVLEALA RLAVEHDFYL
210 220 230 240 250
VSDEIYEHLL YEGEHFSPGR VAPEHTLTVN GAAKAFAMTG WRIGYACGPK
260 270 280 290 300
EVIKAMASVS SQSTTSPDTI AQWATLEALT NQEASRAFVE MAREAYRRRR
310 320 330 340 350
DLLLEGLTAL GLKAVRPSGA FYVLMDTSPI APDEVRAAER LLEAGVAVVP
360 370 380
GTDFAAFGHV RLSYATSEEN LRKALERFAR VLGRA
Length:385
Mass (Da):42,051
Last modified:November 1, 1996 - v1
Checksum:iEADF7B7EA127F39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38459 Genomic DNA. Translation: BAA07487.1.
AP008226 Genomic DNA. Translation: BAD69869.1.
RefSeqiWP_011227669.1. NC_006461.1.
YP_143312.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD69869; BAD69869; BAD69869.
GeneIDi3168657.
KEGGittj:TTHA0046.
PATRICi23955021. VBITheThe93045_0044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38459 Genomic DNA. Translation: BAA07487.1.
AP008226 Genomic DNA. Translation: BAD69869.1.
RefSeqiWP_011227669.1. NC_006461.1.
YP_143312.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B5OX-ray2.20A/B1-385[»]
1B5PX-ray1.80A/B1-385[»]
1BJWX-ray1.80A/B1-382[»]
1BKGX-ray2.60A/B/C/D1-385[»]
1GC3X-ray3.30A/B/C/D/E/F/G/H1-385[»]
1GC4X-ray3.30A/B/C/D1-385[»]
1GCKX-ray2.50A/B1-385[»]
5BJ3X-ray2.20A/B/C/D1-385[»]
5BJ4X-ray2.00A/B1-385[»]
ProteinModelPortaliQ56232.
SMRiQ56232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD69869; BAD69869; BAD69869.
GeneIDi3168657.
KEGGittj:TTHA0046.
PATRICi23955021. VBITheThe93045_0044.

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223062.
KOiK00812.
OMAiYIWVDIS.
PhylomeDBiQ56232.

Enzyme and pathway databases

BRENDAi2.6.1.1. 2305.

Miscellaneous databases

EvolutionaryTraceiQ56232.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAT_THET8
AccessioniPrimary (citable) accession number: Q56232
Secondary accession number(s): Q5SM97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.