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Q56226

- NQO11_THET8

UniProt

Q56226 - NQO11_THET8

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Protein

NADH-quinone oxidoreductase subunit 11

Gene
nqo11, TTHA0094
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-98-MONOMER.

Protein family/group databases

TCDBi3.D.1.3.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit 11 (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I chain 11
NDH-1 subunit 11
Gene namesi
Name:nqo11
Ordered Locus Names:TTHA0094
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei25 – 4521Helical; Reviewed predictionAdd
BLAST
Transmembranei59 – 7921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9595NADH-quinone oxidoreductase subunit 11UniRule annotationPRO_0000118523Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 15 different subunits, nqo1 to nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8 and nqo10 to nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9 and nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.

Protein-protein interaction databases

DIPiDIP-59269N.
STRINGi300852.TTHA0094.

Structurei

Secondary structure

1
95
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 2019
Helixi24 – 4926
Helixi52 – 7827
Beta strandi79 – 835
Helixi87 – 893

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HE8X-ray3.30E/K1-95[»]
4HEAX-ray3.30K/S1-95[»]
ProteinModelPortaliQ56226.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0713.
HOGENOMiHOG000066429.
KOiK00340.
OMAiVEDINMM.
OrthoDBiEOG6MSS3R.
PhylomeDBiQ56226.

Family and domain databases

HAMAPiMF_01456. NDH1_NuoK.
InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERiPTHR11434. PTHR11434. 1 hit.
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56226-1 [UniParc]FASTAAdd to Basket

« Hide

MSYLLTSALL FALGVYGVLT RRTAILVFLS IELMLNAANL SLVGFARAYG   50
LDGQVAALMV IAVAAAEVAV GLGLIVAIFR HRESTAVDDL SELRG 95
Length:95
Mass (Da):9,996
Last modified:November 1, 1997 - v1
Checksum:iED9D2A80D2E96592
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52917 Genomic DNA. Translation: AAA97948.1.
AP008226 Genomic DNA. Translation: BAD69917.1.
PIRiT11908.
RefSeqiWP_011227704.1. NC_006461.1.
YP_143360.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD69917; BAD69917; BAD69917.
GeneIDi3169648.
KEGGittj:TTHA0094.
PATRICi23955119. VBITheThe93045_0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52917 Genomic DNA. Translation: AAA97948.1 .
AP008226 Genomic DNA. Translation: BAD69917.1 .
PIRi T11908.
RefSeqi WP_011227704.1. NC_006461.1.
YP_143360.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HE8 X-ray 3.30 E/K 1-95 [» ]
4HEA X-ray 3.30 K/S 1-95 [» ]
ProteinModelPortali Q56226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59269N.
STRINGi 300852.TTHA0094.

Protein family/group databases

TCDBi 3.D.1.3.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD69917 ; BAD69917 ; BAD69917 .
GeneIDi 3169648.
KEGGi ttj:TTHA0094.
PATRICi 23955119. VBITheThe93045_0092.

Phylogenomic databases

eggNOGi COG0713.
HOGENOMi HOG000066429.
KOi K00340.
OMAi VEDINMM.
OrthoDBi EOG6MSS3R.
PhylomeDBi Q56226.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-98-MONOMER.

Family and domain databases

HAMAPi MF_01456. NDH1_NuoK.
InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view ]
PANTHERi PTHR11434. PTHR11434. 1 hit.
Pfami PF00420. Oxidored_q2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The proton-translocating NADH-quinone oxidoreductase (NDH-1) of thermophilic bacterium Thermus thermophilus HB-8. Complete DNA sequence of the gene cluster and thermostable properties of the expressed NQO2 subunit."
    Yano T., Chu S.S., Sled' V.D., Ohnishi T., Yagi T.
    J. Biol. Chem. 272:4201-4211(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiNQO11_THET8
AccessioniPrimary (citable) accession number: Q56226
Secondary accession number(s): Q5SM49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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