Reviewed, UniProtKB/Swiss-Prot Q56226 (NQO11_THET8)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit 11
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I chain 11
    NDH-1 subunit 11

Gene names

Name:	nqo11
Ordered Locus Names:	TTHA0094

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Complete proteome] [HAMAP]

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.
Catalytic activity	NADH + quinone = NAD+ + quinol.
Subunit structure	NDH-1 is composed of 15 different subunits, nqo1 to nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8 and nqo10 to nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9 and nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the complex I subunit 4L family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 95	95	NADH-quinone oxidoreductase subunit 11		PRO_0000118523
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	25 – 45	21	Potential
	Transmembrane	59 – 79	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q56226-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: ED9D2A80D2E96592	FASTA	95	9,996
	10 20 30 40 50 60 MSYLLTSALL FALGVYGVLT RRTAILVFLS IELMLNAANL SLVGFARAYG LDGQVAALMV 70 80 90 IAVAAAEVAV GLGLIVAIFR HRESTAVDDL SELRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The proton-translocating NADH-quinone oxidoreductase (NDH-1) of thermophilic bacterium Thermus thermophilus HB-8. Complete DNA sequence of the gene cluster and thermostable properties of the expressed NQO2 subunit." Yano T., Chu S.S., Sled' V.D., Ohnishi T., Yagi T. J. Biol. Chem. 272:4201-4211(1997) [PubMed: 9020134] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U52917 Genomic DNA. Translation: AAA97948.1. AP008226 Genomic DNA. Translation: BAD69917.1.
PIR	T11908.
RefSeq	YP_143360.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q56226.
Protein family/group databases
TCDB	3.D.1.3.1. proton-translocating NADH dehydrogenase (NDH) family.
Genome annotation databases
GeneID	3169648.
GenomeReviews	Gene locus TTHA0094 in contig AP008226_GR.
KEGG	ttj:TTHA0094.
NMPDR	fig|300852.3.peg.125.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q56226.
OMA	MLLAVNM.
Enzyme and pathway databases
BioCyc	TTHE300852:TTHA0094-MON.
Family and domain databases
InterPro	IPR001133. NADH_UbQ/Q_OxRdtase_chain4L. [Graphical view]
Pfam	PF00420. Oxidored_q2. 1 hit. [Graphical view]
ProDom	PD002107. NADH_dh_ubiq1. 1 hit. PD000359. Oxidred4L. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

NQO11_THET8

Accession

Primary (citable) accession number: Q56226
Secondary accession number(s): Q5SM49

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)