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Q56226

- NQO11_THET8

UniProt

Q56226 - NQO11_THET8

Protein

NADH-quinone oxidoreductase subunit 11

Gene

nqo11

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-98-MONOMER.

    Protein family/group databases

    TCDBi3.D.1.3.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit 11 (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I chain 11
    NDH-1 subunit 11
    Gene namesi
    Name:nqo11
    Ordered Locus Names:TTHA0094
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9595NADH-quinone oxidoreductase subunit 11PRO_0000118523Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 15 different subunits, nqo1 to nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8 and nqo10 to nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9 and nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.

    Protein-protein interaction databases

    DIPiDIP-59269N.
    STRINGi300852.TTHA0094.

    Structurei

    Secondary structure

    1
    95
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 2019
    Helixi24 – 4926
    Helixi52 – 7827
    Beta strandi79 – 835
    Helixi87 – 893

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HE8X-ray3.30E/K1-95[»]
    4HEAX-ray3.30K/S1-95[»]
    ProteinModelPortaliQ56226.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei25 – 4521HelicalUniRule annotationAdd
    BLAST
    Transmembranei59 – 7921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4L family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0713.
    HOGENOMiHOG000066429.
    KOiK00340.
    OMAiVEDINMM.
    OrthoDBiEOG6MSS3R.
    PhylomeDBiQ56226.

    Family and domain databases

    HAMAPiMF_01456. NDH1_NuoK.
    InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view]
    PANTHERiPTHR11434. PTHR11434. 1 hit.
    PfamiPF00420. Oxidored_q2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q56226-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYLLTSALL FALGVYGVLT RRTAILVFLS IELMLNAANL SLVGFARAYG   50
    LDGQVAALMV IAVAAAEVAV GLGLIVAIFR HRESTAVDDL SELRG 95
    Length:95
    Mass (Da):9,996
    Last modified:November 1, 1997 - v1
    Checksum:iED9D2A80D2E96592
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52917 Genomic DNA. Translation: AAA97948.1.
    AP008226 Genomic DNA. Translation: BAD69917.1.
    PIRiT11908.
    RefSeqiWP_011227704.1. NC_006461.1.
    YP_143360.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD69917; BAD69917; BAD69917.
    GeneIDi3169648.
    KEGGittj:TTHA0094.
    PATRICi23955119. VBITheThe93045_0092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52917 Genomic DNA. Translation: AAA97948.1 .
    AP008226 Genomic DNA. Translation: BAD69917.1 .
    PIRi T11908.
    RefSeqi WP_011227704.1. NC_006461.1.
    YP_143360.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HE8 X-ray 3.30 E/K 1-95 [» ]
    4HEA X-ray 3.30 K/S 1-95 [» ]
    ProteinModelPortali Q56226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59269N.
    STRINGi 300852.TTHA0094.

    Protein family/group databases

    TCDBi 3.D.1.3.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD69917 ; BAD69917 ; BAD69917 .
    GeneIDi 3169648.
    KEGGi ttj:TTHA0094.
    PATRICi 23955119. VBITheThe93045_0092.

    Phylogenomic databases

    eggNOGi COG0713.
    HOGENOMi HOG000066429.
    KOi K00340.
    OMAi VEDINMM.
    OrthoDBi EOG6MSS3R.
    PhylomeDBi Q56226.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-98-MONOMER.

    Family and domain databases

    HAMAPi MF_01456. NDH1_NuoK.
    InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view ]
    PANTHERi PTHR11434. PTHR11434. 1 hit.
    Pfami PF00420. Oxidored_q2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The proton-translocating NADH-quinone oxidoreductase (NDH-1) of thermophilic bacterium Thermus thermophilus HB-8. Complete DNA sequence of the gene cluster and thermostable properties of the expressed NQO2 subunit."
      Yano T., Chu S.S., Sled' V.D., Ohnishi T., Yagi T.
      J. Biol. Chem. 272:4201-4211(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.

    Entry informationi

    Entry nameiNQO11_THET8
    AccessioniPrimary (citable) accession number: Q56226
    Secondary accession number(s): Q5SM49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3