Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-quinone oxidoreductase subunit 5

Gene

nqo5

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The Nqo5 subunit may be involved in the stabilization of the complex.2 Publications

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-89-MONOMER

Protein family/group databases

TCDBi3.D.1.3.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit 5 (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I chain 5
NDH-1 subunit 5
Gene namesi
Name:nqo5
Ordered Locus Names:TTHA0086
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001186691 – 207NADH-quinone oxidoreductase subunit 5Add BLAST207

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers. The N-terminal domain of this subunit (residues 1 to 153) wraps around Nqo4 on one side, and the subunit interacts also with Nqo9 via a two-stranded beta sheet (residues 154 to 171) and with Nqo3 via an extended C-terminal loop (residues 172 to 196).2 Publications

Protein-protein interaction databases

DIPiDIP-59263N
IntActiQ56219, 1 interactor
STRINGi300852.TTHA0086

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 13Combined sources12
Beta strandi17 – 19Combined sources3
Beta strandi21 – 23Combined sources3
Beta strandi25 – 28Combined sources4
Helixi31 – 43Combined sources13
Beta strandi48 – 56Combined sources9
Beta strandi59 – 62Combined sources4
Beta strandi65 – 75Combined sources11
Turni80 – 82Combined sources3
Beta strandi87 – 94Combined sources8
Beta strandi96 – 98Combined sources3
Beta strandi100 – 102Combined sources3
Turni105 – 107Combined sources3
Helixi111 – 122Combined sources12
Beta strandi125 – 127Combined sources3
Beta strandi135 – 137Combined sources3
Beta strandi141 – 143Combined sources3
Beta strandi145 – 147Combined sources3
Beta strandi160 – 162Combined sources3
Helixi167 – 169Combined sources3
Beta strandi176 – 178Combined sources3
Beta strandi181 – 183Combined sources3
Helixi187 – 189Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FUGX-ray3.305/E/N/W1-207[»]
2YBBelectron microscopy19.0051-207[»]
3I9VX-ray3.105/E1-207[»]
3IAMX-ray3.105/E1-207[»]
3IASX-ray3.155/E/N/W1-207[»]
3M9SX-ray4.505/E1-207[»]
4HEAX-ray3.305/F1-207[»]
5B3PX-ray1.65A1-134[»]
5B3QX-ray3.00A1-134[»]
ProteinModelPortaliQ56219
SMRiQ56219
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56219

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CYU Bacteria
COG0852 LUCA
HOGENOMiHOG000099654
KOiK00332
OMAiPTLFKEG
PhylomeDBiQ56219

Family and domain databases

Gene3Di3.30.460.80, 1 hit
HAMAPiMF_01357 NDH1_NuoC, 1 hit
InterProiView protein in InterPro
IPR010218 NADH_DH_suC
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR020396 NADH_UbQ_OxRdtase_CS
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
PROSITEiView protein in PROSITE
PS00542 COMPLEX1_30K, 1 hit

Sequencei

Sequence statusi: Complete.

Q56219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLERVLEEA RAKGYPIEDN GLGNLWVVLP RERFKEEMAH YKAMGFNFLA
60 70 80 90 100
DIVGLDYLTY PDPRPERFAV VYELVSLPGW KDGDGSRFFV RVYVPEEDPR
110 120 130 140 150
LPTVTDLWGS ANFLEREVYD LFGIVFEGHP DLRKILTPED LEGHPLRKDY
160 170 180 190 200
PLGETPTLFR EGRYIIPAEF RAALTGKDPG LTFYKGGSRK GYRSLWADLK

KAREVKG
Length:207
Mass (Da):23,859
Last modified:November 1, 1997 - v1
Checksum:iEB6891BEF6F314AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52917 Genomic DNA Translation: AAA97940.1
AP008226 Genomic DNA Translation: BAD69909.1
PIRiT11900
RefSeqiWP_011174270.1, NC_006461.1
YP_143352.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD69909; BAD69909; BAD69909
GeneIDi3168317
KEGGittj:TTHA0086
PATRICifig|300852.9.peg.84

Similar proteinsi

Entry informationi

Entry nameiNQO5_THET8
AccessioniPrimary (citable) accession number: Q56219
Secondary accession number(s): Q5SM57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health