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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Thermus aquaticus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi583 – 5908ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutS
Gene namesi
Name:mutS
OrganismiThermus aquaticus
Taxonomic identifieri271 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811DNA mismatch repair protein MutSPRO_0000115156Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi498848.TaqDRAFT_3776.

Structurei

Secondary structure

1
811
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 2612Combined sources
Beta strandi30 – 367Combined sources
Beta strandi39 – 435Combined sources
Helixi44 – 5411Combined sources
Beta strandi59 – 624Combined sources
Beta strandi67 – 748Combined sources
Helixi75 – 773Combined sources
Helixi78 – 8710Combined sources
Beta strandi92 – 976Combined sources
Helixi101 – 1033Combined sources
Beta strandi105 – 1073Combined sources
Beta strandi110 – 1167Combined sources
Helixi118 – 1203Combined sources
Helixi124 – 1263Combined sources
Beta strandi134 – 14815Combined sources
Turni150 – 1523Combined sources
Beta strandi155 – 1628Combined sources
Helixi163 – 17311Combined sources
Beta strandi176 – 1805Combined sources
Helixi182 – 1865Combined sources
Helixi188 – 19710Combined sources
Beta strandi200 – 2034Combined sources
Beta strandi211 – 2133Combined sources
Helixi215 – 23218Combined sources
Helixi246 – 2483Combined sources
Helixi254 – 2596Combined sources
Beta strandi262 – 2643Combined sources
Beta strandi266 – 2683Combined sources
Helixi272 – 2765Combined sources
Helixi282 – 29312Combined sources
Helixi299 – 31416Combined sources
Helixi316 – 32611Combined sources
Helixi332 – 3409Combined sources
Helixi346 – 36621Combined sources
Helixi368 – 3703Combined sources
Helixi376 – 38510Combined sources
Beta strandi392 – 3976Combined sources
Helixi406 – 43328Combined sources
Beta strandi439 – 4435Combined sources
Turni444 – 4463Combined sources
Beta strandi447 – 4537Combined sources
Helixi454 – 4596Combined sources
Beta strandi465 – 4695Combined sources
Beta strandi471 – 4777Combined sources
Helixi479 – 51133Combined sources
Helixi514 – 54027Combined sources
Beta strandi546 – 55611Combined sources
Helixi561 – 5633Combined sources
Beta strandi570 – 5767Combined sources
Beta strandi578 – 5836Combined sources
Beta strandi585 – 5884Combined sources
Helixi589 – 60315Combined sources
Turni604 – 6063Combined sources
Beta strandi609 – 6168Combined sources
Beta strandi620 – 6256Combined sources
Helixi638 – 65215Combined sources
Beta strandi657 – 6637Combined sources
Turni664 – 6674Combined sources
Helixi670 – 68718Combined sources
Beta strandi690 – 6945Combined sources
Helixi698 – 7014Combined sources
Beta strandi708 – 7169Combined sources
Beta strandi719 – 7213Combined sources
Beta strandi723 – 7319Combined sources
Helixi738 – 7447Combined sources
Helixi749 – 76214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EWQX-ray2.20A/B1-765[»]
1EWRX-ray3.19A/B117-765[»]
1FW6X-ray2.70A/B1-768[»]
1NNEX-ray3.11A/B1-765[»]
ProteinModelPortaliQ56215.
SMRiQ56215. Positions 1-765.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56215.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiENOG4105D86. Bacteria.
COG0249. LUCA.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS. 1 hit.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGMLKGEGP GPLPPLLQQY VELRDQYPDY LLLFQVGDFY ECFGEDAERL
60 70 80 90 100
ARALGLVLTH KTSKDFTTPM AGIPLRAFEA YAERLLKMGF RLAVADQVEP
110 120 130 140 150
AEEAEGLVRR EVTQLLTPGT LLQESLLPRE ANYLAAIATG DGWGLAFLDV
160 170 180 190 200
STGEFKGTVL KSKSALYDEL FRHRPAEVLL APELLENGAF LDEFRKRFPV
210 220 230 240 250
MLSEAPFEPE GEGPLALRRA RGALLAYAQR TQGGALSLQP FRFYDPGAFM
260 270 280 290 300
RLPEATLRAL EVFEPLRGQD TLFSVLDETR TAPGRRLLQS WLRHPLLDRG
310 320 330 340 350
PLEARLDRVE GFVREGALRE GVRRLLYRLA DLERLATRLE LGRASPKDLG
360 370 380 390 400
ALRRSLQILP ELRALLGEEV GLPDLSPLKE ELEAALVEDP PLKVSEGGLI
410 420 430 440 450
REGYDPDLDA LRAAHREGVA YFLELEERER ERTGIPTLKV GYNAVFGYYL
460 470 480 490 500
EVTRPYYERV PKEYRPVQTL KDRQRYTLPE MKEKEREVYR LEALIRRREE
510 520 530 540 550
EVFLEVRERA KRQAEALREA ARILAELDVY AALAEVAVRY GYVRPRFGDR
560 570 580 590 600
LQIRAGRHPV VERRTEFVPN DLEMAHELVL ITGPNMAGKS TFLRQTALIA
610 620 630 640 650
LLAQVGSFVP AEEAHLPLFD GIYTRIGASD DLAGGKSTFM VEMEEVALIL
660 670 680 690 700
KEATENSLVL LDEVGRGTSS LDGVAIATAV AEALHERRAY TLFATHYFEL
710 720 730 740 750
TALGLPRLKN LHVAAREEAG GLVFYHQVLP GPASKSYGVE VAAMAGLPKE
760 770 780 790 800
VVARARALLQ AMAARREGAL DAVLERLLAL DPDRLTPLEA LRLLQELKAL
810
ALGAPLDTMK G
Length:811
Mass (Da):90,627
Last modified:November 1, 1997 - v1
Checksum:i43A5E5296A333515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33117 Genomic DNA. Translation: AAC43637.1.
RefSeqiWP_053767724.1. NZ_LHCI01000106.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33117 Genomic DNA. Translation: AAC43637.1.
RefSeqiWP_053767724.1. NZ_LHCI01000106.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EWQX-ray2.20A/B1-765[»]
1EWRX-ray3.19A/B117-765[»]
1FW6X-ray2.70A/B1-768[»]
1NNEX-ray3.11A/B1-765[»]
ProteinModelPortaliQ56215.
SMRiQ56215. Positions 1-765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi498848.TaqDRAFT_3776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105D86. Bacteria.
COG0249. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ56215.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS. 1 hit.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUTS_THEAQ
AccessioniPrimary (citable) accession number: Q56215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.