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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Thermus aquaticus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi583 – 590ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutS
Gene namesi
Name:mutS
OrganismiThermus aquaticus
Taxonomic identifieri271 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001151561 – 811DNA mismatch repair protein MutSAdd BLAST811

Proteomic databases

PRIDEiQ56215.

Interactioni

Protein-protein interaction databases

STRINGi498848.TaqDRAFT_3776.

Structurei

Secondary structure

1811
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 26Combined sources12
Beta strandi30 – 36Combined sources7
Beta strandi39 – 43Combined sources5
Helixi44 – 54Combined sources11
Beta strandi59 – 62Combined sources4
Beta strandi67 – 74Combined sources8
Helixi75 – 77Combined sources3
Helixi78 – 87Combined sources10
Beta strandi92 – 97Combined sources6
Helixi101 – 103Combined sources3
Beta strandi105 – 107Combined sources3
Beta strandi110 – 116Combined sources7
Helixi118 – 120Combined sources3
Helixi124 – 126Combined sources3
Beta strandi134 – 148Combined sources15
Turni150 – 152Combined sources3
Beta strandi155 – 162Combined sources8
Helixi163 – 173Combined sources11
Beta strandi176 – 180Combined sources5
Helixi182 – 186Combined sources5
Helixi188 – 197Combined sources10
Beta strandi200 – 203Combined sources4
Beta strandi211 – 213Combined sources3
Helixi215 – 232Combined sources18
Helixi246 – 248Combined sources3
Helixi254 – 259Combined sources6
Beta strandi262 – 264Combined sources3
Beta strandi266 – 268Combined sources3
Helixi272 – 276Combined sources5
Helixi282 – 293Combined sources12
Helixi299 – 314Combined sources16
Helixi316 – 326Combined sources11
Helixi332 – 340Combined sources9
Helixi346 – 366Combined sources21
Helixi368 – 370Combined sources3
Helixi376 – 385Combined sources10
Beta strandi392 – 397Combined sources6
Helixi406 – 433Combined sources28
Beta strandi439 – 443Combined sources5
Turni444 – 446Combined sources3
Beta strandi447 – 453Combined sources7
Helixi454 – 459Combined sources6
Beta strandi465 – 469Combined sources5
Beta strandi471 – 477Combined sources7
Helixi479 – 511Combined sources33
Helixi514 – 540Combined sources27
Beta strandi546 – 556Combined sources11
Helixi561 – 563Combined sources3
Beta strandi570 – 576Combined sources7
Beta strandi578 – 583Combined sources6
Beta strandi585 – 588Combined sources4
Helixi589 – 603Combined sources15
Turni604 – 606Combined sources3
Beta strandi609 – 616Combined sources8
Beta strandi620 – 625Combined sources6
Helixi638 – 652Combined sources15
Beta strandi657 – 663Combined sources7
Turni664 – 667Combined sources4
Helixi670 – 687Combined sources18
Beta strandi690 – 694Combined sources5
Helixi698 – 701Combined sources4
Beta strandi708 – 716Combined sources9
Beta strandi719 – 721Combined sources3
Beta strandi723 – 731Combined sources9
Helixi738 – 744Combined sources7
Helixi749 – 762Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EWQX-ray2.20A/B1-765[»]
1EWRX-ray3.19A/B117-765[»]
1FW6X-ray2.70A/B1-768[»]
1NNEX-ray3.11A/B1-765[»]
ProteinModelPortaliQ56215.
SMRiQ56215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56215.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiENOG4105D86. Bacteria.
COG0249. LUCA.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS. 1 hit.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGMLKGEGP GPLPPLLQQY VELRDQYPDY LLLFQVGDFY ECFGEDAERL
60 70 80 90 100
ARALGLVLTH KTSKDFTTPM AGIPLRAFEA YAERLLKMGF RLAVADQVEP
110 120 130 140 150
AEEAEGLVRR EVTQLLTPGT LLQESLLPRE ANYLAAIATG DGWGLAFLDV
160 170 180 190 200
STGEFKGTVL KSKSALYDEL FRHRPAEVLL APELLENGAF LDEFRKRFPV
210 220 230 240 250
MLSEAPFEPE GEGPLALRRA RGALLAYAQR TQGGALSLQP FRFYDPGAFM
260 270 280 290 300
RLPEATLRAL EVFEPLRGQD TLFSVLDETR TAPGRRLLQS WLRHPLLDRG
310 320 330 340 350
PLEARLDRVE GFVREGALRE GVRRLLYRLA DLERLATRLE LGRASPKDLG
360 370 380 390 400
ALRRSLQILP ELRALLGEEV GLPDLSPLKE ELEAALVEDP PLKVSEGGLI
410 420 430 440 450
REGYDPDLDA LRAAHREGVA YFLELEERER ERTGIPTLKV GYNAVFGYYL
460 470 480 490 500
EVTRPYYERV PKEYRPVQTL KDRQRYTLPE MKEKEREVYR LEALIRRREE
510 520 530 540 550
EVFLEVRERA KRQAEALREA ARILAELDVY AALAEVAVRY GYVRPRFGDR
560 570 580 590 600
LQIRAGRHPV VERRTEFVPN DLEMAHELVL ITGPNMAGKS TFLRQTALIA
610 620 630 640 650
LLAQVGSFVP AEEAHLPLFD GIYTRIGASD DLAGGKSTFM VEMEEVALIL
660 670 680 690 700
KEATENSLVL LDEVGRGTSS LDGVAIATAV AEALHERRAY TLFATHYFEL
710 720 730 740 750
TALGLPRLKN LHVAAREEAG GLVFYHQVLP GPASKSYGVE VAAMAGLPKE
760 770 780 790 800
VVARARALLQ AMAARREGAL DAVLERLLAL DPDRLTPLEA LRLLQELKAL
810
ALGAPLDTMK G
Length:811
Mass (Da):90,627
Last modified:November 1, 1997 - v1
Checksum:i43A5E5296A333515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33117 Genomic DNA. Translation: AAC43637.1.
RefSeqiWP_053767724.1. NZ_LHCI01000106.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33117 Genomic DNA. Translation: AAC43637.1.
RefSeqiWP_053767724.1. NZ_LHCI01000106.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EWQX-ray2.20A/B1-765[»]
1EWRX-ray3.19A/B117-765[»]
1FW6X-ray2.70A/B1-768[»]
1NNEX-ray3.11A/B1-765[»]
ProteinModelPortaliQ56215.
SMRiQ56215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi498848.TaqDRAFT_3776.

Proteomic databases

PRIDEiQ56215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105D86. Bacteria.
COG0249. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ56215.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS. 1 hit.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUTS_THEAQ
AccessioniPrimary (citable) accession number: Q56215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.