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Q56213

- GLMS_THET8

UniProt

Q56213 - GLMS_THET8

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, TTHA1896
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei599 – 5991For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1941-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:TTHA1896
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135402Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi300852.TTHA1896.

Structurei

3D structure databases

ProteinModelPortaliQ56213.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 216215Glutamine amidotransferase type-2
Add
BLAST
Domaini281 – 420140SIS 1
Add
BLAST
Domaini453 – 594142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ56213.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56213-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYVGF RNATDVLLDG LRRLEYRGYD SAGIAVRTPE GLKVVKRSGK    50
LSALAEAVGK TPLQGALGIG HTRWATHGAP TDPNAHPHTT EDGRIALIHN 100
GIFENYLELK EALEARGHRF RSETDTEVLA HLLEETYRGD LLEALREALK 150
AVRGAYAVVV AHEDHEEIVA ARTVSPLVVG LGEGENFLAS DVPALLPYTR 200
RVLFLHDGDV VRLTREGVEI TDLEGRPVQR EAVEVDWTLE AAEKGGFPHY 250
MLKEIYEQPW VLENTLGGRL REEEGTVELG LALDPREVDR VHVIACGTAS 300
YAGLYGKYLL ETLARLPTEW DVASEYRYRD PVVDSRTLAL AISQSGETID 350
TLEGLREAKR KGARSLGVIN AKGSTLTREV EDVLYIHAGP EIGVASTKAY 400
TAMLAAMALL AVWFGRGRGA LALEEAQRLL REMRRLPRLV EEVLEKRPLV 450
AHVAEKYHQA RDFLFLGRHV QAPTAYEGAL KLKEISYIHA EAYPAGEMKH 500
GPIALIDEHL PVVVLATKGP LYEKTLSNIQ EVRARGGKVI AIATEGDEEI 550
PRLAQDVIYV PEVHPLLAPI VSVVPLQLLA YEIAVLLGRD VDQPRNLAKS 600
VTVE 604
Length:604
Mass (Da):66,485
Last modified:January 23, 2007 - v4
Checksum:iD3D2E400AA4B5A1D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531A → S in AAA86988. 1 Publication
Sequence conflicti203 – 2031L → I in AAA86988. 1 Publication
Sequence conflicti412 – 4121V → I in AAA86988. 1 Publication
Sequence conflicti417 – 4171G → A in AAA86988. 1 Publication
Sequence conflicti423 – 4231L → P in AAA86988. 1 Publication
Sequence conflicti461 – 4611R → Q in AAA86988. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17352 Genomic DNA. Translation: AAA86988.1.
AP008226 Genomic DNA. Translation: BAD71719.1.
RefSeqiYP_145162.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71719; BAD71719; BAD71719.
GeneIDi3168001.
KEGGittj:TTHA1896.
PATRICi23958755. VBITheThe93045_1864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17352 Genomic DNA. Translation: AAA86988.1 .
AP008226 Genomic DNA. Translation: BAD71719.1 .
RefSeqi YP_145162.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q56213.
ModBasei Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1896.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71719 ; BAD71719 ; BAD71719 .
GeneIDi 3168001.
KEGGi ttj:TTHA1896.
PATRICi 23958755. VBITheThe93045_1864.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q56213.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1941-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "glmS of Thermus thermophilus HB8: an essential gene for cell-wall synthesis identified immediately upstream of the S-layer gene."
    Fernandez-Herrero L.A., Badet-Denisot M.-A., Badet B., Berenguer J.
    Mol. Microbiol. 17:1-12(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiGLMS_THET8
AccessioniPrimary (citable) accession number: Q56213
Secondary accession number(s): Q5SH34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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