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Q56213

- GLMS_THET8

UniProt

Q56213 - GLMS_THET8

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei599 – 5991For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1941-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:TTHA1896
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135402Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi300852.TTHA1896.

Structurei

3D structure databases

ProteinModelPortaliQ56213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 216215Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini281 – 420140SIS 1UniRule annotationAdd
BLAST
Domaini453 – 594142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ56213.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56213-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYVGF RNATDVLLDG LRRLEYRGYD SAGIAVRTPE GLKVVKRSGK
60 70 80 90 100
LSALAEAVGK TPLQGALGIG HTRWATHGAP TDPNAHPHTT EDGRIALIHN
110 120 130 140 150
GIFENYLELK EALEARGHRF RSETDTEVLA HLLEETYRGD LLEALREALK
160 170 180 190 200
AVRGAYAVVV AHEDHEEIVA ARTVSPLVVG LGEGENFLAS DVPALLPYTR
210 220 230 240 250
RVLFLHDGDV VRLTREGVEI TDLEGRPVQR EAVEVDWTLE AAEKGGFPHY
260 270 280 290 300
MLKEIYEQPW VLENTLGGRL REEEGTVELG LALDPREVDR VHVIACGTAS
310 320 330 340 350
YAGLYGKYLL ETLARLPTEW DVASEYRYRD PVVDSRTLAL AISQSGETID
360 370 380 390 400
TLEGLREAKR KGARSLGVIN AKGSTLTREV EDVLYIHAGP EIGVASTKAY
410 420 430 440 450
TAMLAAMALL AVWFGRGRGA LALEEAQRLL REMRRLPRLV EEVLEKRPLV
460 470 480 490 500
AHVAEKYHQA RDFLFLGRHV QAPTAYEGAL KLKEISYIHA EAYPAGEMKH
510 520 530 540 550
GPIALIDEHL PVVVLATKGP LYEKTLSNIQ EVRARGGKVI AIATEGDEEI
560 570 580 590 600
PRLAQDVIYV PEVHPLLAPI VSVVPLQLLA YEIAVLLGRD VDQPRNLAKS

VTVE
Length:604
Mass (Da):66,485
Last modified:January 23, 2007 - v4
Checksum:iD3D2E400AA4B5A1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531A → S in AAA86988. (PubMed:7476196)Curated
Sequence conflicti203 – 2031L → I in AAA86988. (PubMed:7476196)Curated
Sequence conflicti412 – 4121V → I in AAA86988. (PubMed:7476196)Curated
Sequence conflicti417 – 4171G → A in AAA86988. (PubMed:7476196)Curated
Sequence conflicti423 – 4231L → P in AAA86988. (PubMed:7476196)Curated
Sequence conflicti461 – 4611R → Q in AAA86988. (PubMed:7476196)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17352 Genomic DNA. Translation: AAA86988.1.
AP008226 Genomic DNA. Translation: BAD71719.1.
RefSeqiYP_145162.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71719; BAD71719; BAD71719.
GeneIDi3168001.
KEGGittj:TTHA1896.
PATRICi23958755. VBITheThe93045_1864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17352 Genomic DNA. Translation: AAA86988.1 .
AP008226 Genomic DNA. Translation: BAD71719.1 .
RefSeqi YP_145162.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q56213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1896.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71719 ; BAD71719 ; BAD71719 .
GeneIDi 3168001.
KEGGi ttj:TTHA1896.
PATRICi 23958755. VBITheThe93045_1864.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q56213.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1941-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "glmS of Thermus thermophilus HB8: an essential gene for cell-wall synthesis identified immediately upstream of the S-layer gene."
    Fernandez-Herrero L.A., Badet-Denisot M.-A., Badet B., Berenguer J.
    Mol. Microbiol. 17:1-12(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiGLMS_THET8
AccessioniPrimary (citable) accession number: Q56213
Secondary accession number(s): Q5SH34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 97 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3