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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Gene

Ndufa10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Alternative name(s):
Complex I-42kD
Short name:
CI-42kD
NADH-ubiquinone oxidoreductase 42 kDa subunit
Gene namesi
Name:Ndufa10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi727968. Ndufa10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000027076136 – 355NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122N6-acetyllysine; alternateBy similarity1
Modified residuei122N6-succinyllysine; alternateBy similarity1
Modified residuei250Phosphoserine; by PINK1By similarity1
Modified residuei285N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ561S0.
PRIDEiQ561S0.

2D gel databases

World-2DPAGEi0004:Q561S0.

PTM databases

iPTMnetiQ561S0.
PhosphoSitePlusiQ561S0.

Expressioni

Tissue specificityi

Expressed in the head and flagellum of epididymal sperm but not in testicular sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000016470.
GenevisibleiQ561S0. RN.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022089.

Structurei

3D structure databases

ProteinModelPortaliQ561S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA10 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3877. Eukaryota.
ENOG41101CN. LUCA.
GeneTreeiENSGT00390000016151.
HOGENOMiHOG000267026.
HOVERGENiHBG002308.
InParanoidiQ561S0.
KOiK03954.
OMAiKPHLVIY.
OrthoDBiEOG091G0WZ0.
PhylomeDBiQ561S0.
TreeFamiTF314616.

Family and domain databases

CDDicd02030. NDUO42. 1 hit.
InterProiView protein in InterPro
IPR031314. DNK_dom.
IPR015828. NDUFA10.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01712. dNK. 1 hit.
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q561S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRLLRLVP ASASARGLAA GAQRVGRIHT SVHCKLRYGL LASILGDKTT
60 70 80 90 100
KKLHEYSRVI TVDGNICSGK NKLARDIAEQ LGMKHYPEAG IQYSSSTTGD
110 120 130 140 150
GRPLDIEFSG SCSLEKFYDN PKSNDGNSYR LQSWLYASRL LQYSDALEHL
160 170 180 190 200
LSTGQGVVLE RSIYSDFVFL EAMYNQGFIR KQCVDHYNEI KRLTLPEYLP
210 220 230 240 250
PHAVIYIDVP VSEIQSRIQK KGDPHEMKVT SAYLQDIEDA YKKTFLPKMS
260 270 280 290 300
EICEVLVYSS WEAEDSTKVV EDIEYLNYNK GPWLKQDDRT FHNLRMLVQD
310 320 330 340 350
KREVLNYTTV PVYLPEITIG AHQGSRIYDS FRELPGRKYA PGYNADVGDK

WIWLK
Length:355
Mass (Da):40,493
Last modified:May 10, 2005 - v1
Checksum:iDB59209F94B2CBD5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120N → D in AAP20092 (Ref. 1) Curated1
Sequence conflicti176Q → R in AAP20092 (Ref. 1) Curated1
Sequence conflicti201P → S in AAP20092 (Ref. 1) Curated1
Sequence conflicti248K → Q in AAP20092 (Ref. 1) Curated1
Sequence conflicti257V → M in AAP20092 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260163 mRNA. Translation: AAP20092.1.
BC093375 mRNA. Translation: AAH93375.1.
RefSeqiNP_872612.1. NM_182671.2.
NP_955789.2. NM_199495.2.
UniGeneiRn.102304.
Rn.169414.

Genome annotation databases

EnsembliENSRNOT00000022089; ENSRNOP00000022089; ENSRNOG00000016470.
GeneIDi316632.
678759.
KEGGirno:316632.
rno:678759.
UCSCiRGD:727968. rat.

Similar proteinsi

Entry informationi

Entry nameiNDUAA_RAT
AccessioniPrimary (citable) accession number: Q561S0
Secondary accession number(s): Q80WE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families