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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Gene

Ndufa10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
  • response to drug Source: RGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Alternative name(s):
Complex I-42kD
Short name:
CI-42kD
NADH-ubiquinone oxidoreductase 42 kDa subunit
Gene namesi
Name:Ndufa10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi727968. Ndufa10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionBy similarityAdd
BLAST
Chaini36 – 355320NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialPRO_0000270761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221N6-acetyllysine; alternateBy similarity
Modified residuei122 – 1221N6-succinyllysine; alternateBy similarity
Modified residuei285 – 2851N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ561S0.
PRIDEiQ561S0.

2D gel databases

World-2DPAGE0004:Q561S0.

PTM databases

iPTMnetiQ561S0.
PhosphoSiteiQ561S0.

Expressioni

Tissue specificityi

Expressed in the head and flagellum of epididymal sperm but not in testicular sperm (at protein level).1 Publication

Gene expression databases

GenevisibleiQ561S0. RN.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022089.

Structurei

3D structure databases

ProteinModelPortaliQ561S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA10 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3877. Eukaryota.
ENOG41101CN. LUCA.
GeneTreeiENSGT00390000016151.
HOGENOMiHOG000267026.
HOVERGENiHBG002308.
InParanoidiQ561S0.
KOiK03954.
OMAiKPHLVIY.
OrthoDBiEOG741Z21.
PhylomeDBiQ561S0.
TreeFamiTF314616.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031314. DNK_dom.
IPR015828. NDUFA10.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q561S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRLLRLVP ASASARGLAA GAQRVGRIHT SVHCKLRYGL LASILGDKTT
60 70 80 90 100
KKLHEYSRVI TVDGNICSGK NKLARDIAEQ LGMKHYPEAG IQYSSSTTGD
110 120 130 140 150
GRPLDIEFSG SCSLEKFYDN PKSNDGNSYR LQSWLYASRL LQYSDALEHL
160 170 180 190 200
LSTGQGVVLE RSIYSDFVFL EAMYNQGFIR KQCVDHYNEI KRLTLPEYLP
210 220 230 240 250
PHAVIYIDVP VSEIQSRIQK KGDPHEMKVT SAYLQDIEDA YKKTFLPKMS
260 270 280 290 300
EICEVLVYSS WEAEDSTKVV EDIEYLNYNK GPWLKQDDRT FHNLRMLVQD
310 320 330 340 350
KREVLNYTTV PVYLPEITIG AHQGSRIYDS FRELPGRKYA PGYNADVGDK

WIWLK
Length:355
Mass (Da):40,493
Last modified:May 10, 2005 - v1
Checksum:iDB59209F94B2CBD5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201N → D in AAP20092 (Ref. 1) Curated
Sequence conflicti176 – 1761Q → R in AAP20092 (Ref. 1) Curated
Sequence conflicti201 – 2011P → S in AAP20092 (Ref. 1) Curated
Sequence conflicti248 – 2481K → Q in AAP20092 (Ref. 1) Curated
Sequence conflicti257 – 2571V → M in AAP20092 (Ref. 1) Curated

Mass spectrometryi

Molecular mass is 40467.64 Da from positions 1 - 355. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260163 mRNA. Translation: AAP20092.1.
BC093375 mRNA. Translation: AAH93375.1.
RefSeqiNP_872612.1. NM_182671.2.
NP_955789.2. NM_199495.2.
UniGeneiRn.102304.
Rn.169414.

Genome annotation databases

EnsembliENSRNOT00000022089; ENSRNOP00000022089; ENSRNOG00000016470.
GeneIDi316632.
678759.
KEGGirno:316632.
rno:678759.
UCSCiRGD:727968. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260163 mRNA. Translation: AAP20092.1.
BC093375 mRNA. Translation: AAH93375.1.
RefSeqiNP_872612.1. NM_182671.2.
NP_955789.2. NM_199495.2.
UniGeneiRn.102304.
Rn.169414.

3D structure databases

ProteinModelPortaliQ561S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022089.

PTM databases

iPTMnetiQ561S0.
PhosphoSiteiQ561S0.

2D gel databases

World-2DPAGE0004:Q561S0.

Proteomic databases

PaxDbiQ561S0.
PRIDEiQ561S0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022089; ENSRNOP00000022089; ENSRNOG00000016470.
GeneIDi316632.
678759.
KEGGirno:316632.
rno:678759.
UCSCiRGD:727968. rat.

Organism-specific databases

CTDi316632.
4705.
RGDi727968. Ndufa10.

Phylogenomic databases

eggNOGiKOG3877. Eukaryota.
ENOG41101CN. LUCA.
GeneTreeiENSGT00390000016151.
HOGENOMiHOG000267026.
HOVERGENiHBG002308.
InParanoidiQ561S0.
KOiK03954.
OMAiKPHLVIY.
OrthoDBiEOG741Z21.
PhylomeDBiQ561S0.
TreeFamiTF314616.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Miscellaneous databases

NextBioi671104.
PROiQ561S0.

Gene expression databases

GenevisibleiQ561S0. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031314. DNK_dom.
IPR015828. NDUFA10.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zhang G., Liu F., Yang P.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 140-161; 182-192 AND 303-326, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  4. "Differential proteomics leads to identification of domain specific epididymal sperm proteins."
    Suryawanshi A.R., Khan S.A., Gajbhiye R.K., Gurav M.Y., Khole V.V.
    J. Androl. 32:240-259(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Strain: Holtzman.
    Tissue: Sperm.

Entry informationi

Entry nameiNDUAA_RAT
AccessioniPrimary (citable) accession number: Q561S0
Secondary accession number(s): Q80WE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.