Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Marginal zone B- and B1-cell-specific protein

Gene

Mzb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation.By similarity
Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Marginal zone B- and B1-cell-specific protein
Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name:
Plasma cell-induced resident ER protein
Short name:
pERp1
Proapoptotic caspase adapter protein
Gene namesi
Name:Mzb1
Synonyms:Pacap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1310251 Mzb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031874222 – 188Marginal zone B- and B1-cell-specific proteinAdd BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 177By similarity
Disulfide bondi52 ↔ 170By similarity
Disulfide bondi94 ↔ 142By similarity

Post-translational modificationi

Forms an interchain disulfide bond with IgM monomers.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ561R0
PRIDEiQ561R0

Expressioni

Gene expression databases

BgeeiENSRNOG00000022009
GenevisibleiQ561R0 RN

Interactioni

Subunit structurei

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030810

Structurei

3D structure databases

SMRiQ561R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi185 – 188Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the MZB1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J06F Eukaryota
ENOG4111YKY LUCA
GeneTreeiENSGT00390000002716
HOVERGENiHBG108230
InParanoidiQ561R0
OMAiEKYSAHM
OrthoDBiEOG091G1197
PhylomeDBiQ561R0
TreeFamiTF329450

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q561R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPLPLLLL FGCRAILGSF GDRVSLSATA PTLDDEEKYA SHMPTHLRCD
60 70 80 90 100
ACRAVAYQMG QHLAKAEAKS HTPDSSGSQE LSESTYTDVL DRTCSQNWQS
110 120 130 140 150
YGVQEVNQMK RLMGPGLSKG PEPSISVMIT GGPWPNRLSM TCFHYLGEFG
160 170 180
EDQIYEAYRQ GHETLEALLC GGTHGSCSQE IPAQREEL
Length:188
Mass (Da):20,712
Last modified:May 10, 2005 - v1
Checksum:i9C29308904B277A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093397 mRNA Translation: AAH93397.1
RefSeqiNP_001019411.1, NM_001024240.1
UniGeneiRn.19595

Genome annotation databases

EnsembliENSRNOT00000036301; ENSRNOP00000030810; ENSRNOG00000022009
GeneIDi291675
KEGGirno:291675
UCSCiRGD:1310251 rat

Similar proteinsi

Entry informationi

Entry nameiMZB1_RAT
AccessioniPrimary (citable) accession number: Q561R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health