Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Marginal zone B- and B1-cell-specific protein

Gene

Mzb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation.By similarity
Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance (By similarity).By similarity

GO - Biological processi

  1. integrin activation Source: UniProtKB
  2. negative regulation of glucose import in response to insulin stimulus Source: UniProtKB
  3. positive regulation of cell proliferation Source: UniProtKB
  4. positive regulation of immunoglobulin biosynthetic process Source: UniProtKB
  5. regulation of B cell proliferation Source: UniProtKB
  6. regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Marginal zone B- and B1-cell-specific protein
Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name:
Plasma cell-induced resident ER protein
Short name:
pERp1
Proapoptotic caspase adapter protein
Gene namesi
Name:Mzb1
Synonyms:Pacap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi1310251. Mzb1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation. Secreted By similarity

GO - Cellular componenti

  1. endoplasmic reticulum chaperone complex Source: UniProtKB
  2. endoplasmic reticulum lumen Source: UniProtKB
  3. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 188167Marginal zone B- and B1-cell-specific proteinPRO_0000318742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 177By similarity
Disulfide bondi52 ↔ 170By similarity
Disulfide bondi94 ↔ 142By similarity

Post-translational modificationi

Forms an interchain disulfide bond with IgM monomers.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ561R0.
PRIDEiQ561R0.

Expressioni

Gene expression databases

GenevestigatoriQ561R0.

Interactioni

Subunit structurei

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030810.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi185 – 1884Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the MZB1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74024.
GeneTreeiENSGT00390000002716.
HOVERGENiHBG108230.
InParanoidiQ561R0.
OMAiEKYSAHM.
OrthoDBiEOG7D2FFZ.
PhylomeDBiQ561R0.
TreeFamiTF329450.

Family and domain databases

InterProiIPR021852. DUF3456.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q561R0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLPLPLLLL FGCRAILGSF GDRVSLSATA PTLDDEEKYA SHMPTHLRCD
60 70 80 90 100
ACRAVAYQMG QHLAKAEAKS HTPDSSGSQE LSESTYTDVL DRTCSQNWQS
110 120 130 140 150
YGVQEVNQMK RLMGPGLSKG PEPSISVMIT GGPWPNRLSM TCFHYLGEFG
160 170 180
EDQIYEAYRQ GHETLEALLC GGTHGSCSQE IPAQREEL
Length:188
Mass (Da):20,712
Last modified:May 10, 2005 - v1
Checksum:i9C29308904B277A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093397 mRNA. Translation: AAH93397.1.
RefSeqiNP_001019411.1. NM_001024240.1.
UniGeneiRn.19595.

Genome annotation databases

EnsembliENSRNOT00000036301; ENSRNOP00000030810; ENSRNOG00000022009.
GeneIDi291675.
KEGGirno:291675.
UCSCiRGD:1310251. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093397 mRNA. Translation: AAH93397.1.
RefSeqiNP_001019411.1. NM_001024240.1.
UniGeneiRn.19595.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030810.

Proteomic databases

PaxDbiQ561R0.
PRIDEiQ561R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036301; ENSRNOP00000030810; ENSRNOG00000022009.
GeneIDi291675.
KEGGirno:291675.
UCSCiRGD:1310251. rat.

Organism-specific databases

CTDi51237.
RGDi1310251. Mzb1.

Phylogenomic databases

eggNOGiNOG74024.
GeneTreeiENSGT00390000002716.
HOVERGENiHBG108230.
InParanoidiQ561R0.
OMAiEKYSAHM.
OrthoDBiEOG7D2FFZ.
PhylomeDBiQ561R0.
TreeFamiTF329450.

Miscellaneous databases

NextBioi632995.
PROiQ561R0.

Gene expression databases

GenevestigatoriQ561R0.

Family and domain databases

InterProiIPR021852. DUF3456.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiMZB1_RAT
AccessioniPrimary (citable) accession number: Q561R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.