Q561R0 (MZB1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Marginal zone B- and B1-cell-specific protein

Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name=Plasma cell-induced resident ER protein
Short name=pERp1
Proapoptotic caspase adapter protein

Gene names

Name:	Mzb1
Synonyms:	Pacap

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity By similarity. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation. Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance By similarity.
Subunit structure	Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains By similarity. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity. Secreted By similarity.
Post-translational modification	Forms an interchain disulfide bond with IgM monomers By similarity.
Sequence similarities	Belongs to the MZB1 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Secreted
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	integrin activation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of glucose import in response to insulin stimulus Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of immunoglobulin biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of B cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	endoplasmic reticulum chaperone complex Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum lumen Inferred from sequence or structural similarity. Source: UniProtKB extracellular region Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 188	167	Marginal zone B- and B1-cell-specific protein		PRO_0000318742
Regions
	Motif	185 – 188	4	Prevents secretion from ER Potential
Amino acid modifications
	Disulfide bond	49 ↔ 177		By similarity
	Disulfide bond	52 ↔ 170		By similarity
	Disulfide bond	94 ↔ 142		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q561R0 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 9C29308904B277A7	FASTA	188	20,712
	10 20 30 40 50 60 MRLPLPLLLL FGCRAILGSF GDRVSLSATA PTLDDEEKYA SHMPTHLRCD ACRAVAYQMG 70 80 90 100 110 120 QHLAKAEAKS HTPDSSGSQE LSESTYTDVL DRTCSQNWQS YGVQEVNQMK RLMGPGLSKG 130 140 150 160 170 180 PEPSISVMIT GGPWPNRLSM TCFHYLGEFG EDQIYEAYRQ GHETLEALLC GGTHGSCSQE IPAQREEL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC093397 mRNA. Translation: AAH93397.1.
IPI	IPI00387843.
RefSeq	NP_001019411.1. NM_001024240.1.
UniGene	Rn.19595.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000030810.
Proteomic databases
PaxDb	Q561R0.
PRIDE	Q561R0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000036301; ENSRNOP00000030810; ENSRNOG00000022009.
GeneID	291675.
KEGG	rno:291675.
UCSC	RGD:1310251. rat.
Organism-specific databases
CTD	51237.
RGD	1310251. Mzb1.
Phylogenomic databases
eggNOG	NOG74024.
GeneTree	ENSGT00390000002716.
HOVERGEN	HBG108230.
InParanoid	Q561R0.
OMA	EKYSAHM.
OrthoDB	EOG4ZGPDG.
Gene expression databases
Genevestigator	Q561R0.
Family and domain databases
InterPro	IPR021852. DUF3456. [Graphical view]
Pfam	PF11938. DUF3456. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	632995.

Entry information

Entry name

MZB1_RAT

Accession

Primary (citable) accession number: Q561R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 10, 2005
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program