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Q561R0 (MZB1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Marginal zone B- and B1-cell-specific protein
Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name=Plasma cell-induced resident ER protein
Short name=pERp1
Proapoptotic caspase adapter protein
Gene names
Name:Mzb1
Synonyms:Pacap
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity By similarity. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation.

Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance By similarity.

Subunit structure

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains By similarity. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity. Secreted By similarity.

Post-translational modification

Forms an interchain disulfide bond with IgM monomers By similarity.

Sequence similarities

Belongs to the MZB1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 188167Marginal zone B- and B1-cell-specific protein
PRO_0000318742

Regions

Motif185 – 1884Prevents secretion from ER Potential

Amino acid modifications

Disulfide bond49 ↔ 177 By similarity
Disulfide bond52 ↔ 170 By similarity
Disulfide bond94 ↔ 142 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q561R0 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 9C29308904B277A7

FASTA18820,712
        10         20         30         40         50         60 
MRLPLPLLLL FGCRAILGSF GDRVSLSATA PTLDDEEKYA SHMPTHLRCD ACRAVAYQMG 

        70         80         90        100        110        120 
QHLAKAEAKS HTPDSSGSQE LSESTYTDVL DRTCSQNWQS YGVQEVNQMK RLMGPGLSKG 

       130        140        150        160        170        180 
PEPSISVMIT GGPWPNRLSM TCFHYLGEFG EDQIYEAYRQ GHETLEALLC GGTHGSCSQE 


IPAQREEL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC093397 mRNA. Translation: AAH93397.1.
RefSeqNP_001019411.1. NM_001024240.1.
UniGeneRn.19595.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000030810.

Proteomic databases

PaxDbQ561R0.
PRIDEQ561R0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000036301; ENSRNOP00000030810; ENSRNOG00000022009.
GeneID291675.
KEGGrno:291675.
UCSCRGD:1310251. rat.

Organism-specific databases

CTD51237.
RGD1310251. Mzb1.

Phylogenomic databases

eggNOGNOG74024.
GeneTreeENSGT00390000002716.
HOVERGENHBG108230.
InParanoidQ561R0.
OMAEKYSAHM.
OrthoDBEOG7D2FFZ.
PhylomeDBQ561R0.
TreeFamTF329450.

Gene expression databases

GenevestigatorQ561R0.

Family and domain databases

InterProIPR021852. DUF3456.
[Graphical view]
PfamPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio632995.
PROQ561R0.

Entry information

Entry nameMZB1_RAT
AccessionPrimary (citable) accession number: Q561R0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families