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Q561R0

- MZB1_RAT

UniProt

Q561R0 - MZB1_RAT

Protein

Marginal zone B- and B1-cell-specific protein

Gene

Mzb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity By similarity. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation.By similarity
    Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance By similarity.By similarity

    GO - Biological processi

    1. integrin activation Source: UniProtKB
    2. negative regulation of glucose import in response to insulin stimulus Source: UniProtKB
    3. positive regulation of cell proliferation Source: UniProtKB
    4. positive regulation of immunoglobulin biosynthetic process Source: UniProtKB
    5. regulation of B cell proliferation Source: UniProtKB
    6. regulation of cell proliferation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Marginal zone B- and B1-cell-specific protein
    Alternative name(s):
    Plasma cell-induced resident endoplasmic reticulum protein
    Short name:
    Plasma cell-induced resident ER protein
    Short name:
    pERp1
    Proapoptotic caspase adapter protein
    Gene namesi
    Name:Mzb1
    Synonyms:Pacap
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi1310251. Mzb1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation. Secreted By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum chaperone complex Source: UniProtKB
    2. endoplasmic reticulum lumen Source: UniProtKB
    3. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 188167Marginal zone B- and B1-cell-specific proteinPRO_0000318742Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 177By similarity
    Disulfide bondi52 ↔ 170By similarity
    Disulfide bondi94 ↔ 142By similarity

    Post-translational modificationi

    Forms an interchain disulfide bond with IgM monomers.By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ561R0.
    PRIDEiQ561R0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ561R0.

    Interactioni

    Subunit structurei

    Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000030810.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi185 – 1884Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the MZB1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74024.
    GeneTreeiENSGT00390000002716.
    HOVERGENiHBG108230.
    InParanoidiQ561R0.
    OMAiYQMWQHL.
    OrthoDBiEOG7D2FFZ.
    PhylomeDBiQ561R0.
    TreeFamiTF329450.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    [Graphical view]
    PfamiPF11938. DUF3456. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q561R0-1 [UniParc]FASTAAdd to Basket

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    MRLPLPLLLL FGCRAILGSF GDRVSLSATA PTLDDEEKYA SHMPTHLRCD    50
    ACRAVAYQMG QHLAKAEAKS HTPDSSGSQE LSESTYTDVL DRTCSQNWQS 100
    YGVQEVNQMK RLMGPGLSKG PEPSISVMIT GGPWPNRLSM TCFHYLGEFG 150
    EDQIYEAYRQ GHETLEALLC GGTHGSCSQE IPAQREEL 188
    Length:188
    Mass (Da):20,712
    Last modified:May 10, 2005 - v1
    Checksum:i9C29308904B277A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC093397 mRNA. Translation: AAH93397.1.
    RefSeqiNP_001019411.1. NM_001024240.1.
    UniGeneiRn.19595.

    Genome annotation databases

    EnsembliENSRNOT00000036301; ENSRNOP00000030810; ENSRNOG00000022009.
    GeneIDi291675.
    KEGGirno:291675.
    UCSCiRGD:1310251. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC093397 mRNA. Translation: AAH93397.1 .
    RefSeqi NP_001019411.1. NM_001024240.1.
    UniGenei Rn.19595.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000030810.

    Proteomic databases

    PaxDbi Q561R0.
    PRIDEi Q561R0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000036301 ; ENSRNOP00000030810 ; ENSRNOG00000022009 .
    GeneIDi 291675.
    KEGGi rno:291675.
    UCSCi RGD:1310251. rat.

    Organism-specific databases

    CTDi 51237.
    RGDi 1310251. Mzb1.

    Phylogenomic databases

    eggNOGi NOG74024.
    GeneTreei ENSGT00390000002716.
    HOVERGENi HBG108230.
    InParanoidi Q561R0.
    OMAi YQMWQHL.
    OrthoDBi EOG7D2FFZ.
    PhylomeDBi Q561R0.
    TreeFami TF329450.

    Miscellaneous databases

    NextBioi 632995.
    PROi Q561R0.

    Gene expression databases

    Genevestigatori Q561R0.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    [Graphical view ]
    Pfami PF11938. DUF3456. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiMZB1_RAT
    AccessioniPrimary (citable) accession number: Q561R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3