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Protein

N-terminal kinase-like protein

Gene

scyl1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal kinase-like protein
Alternative name(s):
SCY1-like protein 1
Gene namesi
Name:scyl1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5843636. scyl1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827N-terminal kinase-like proteinPRO_0000249544Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi101874. 1 interaction.
IntActiQ561M0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ561M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 309294Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati345 – 38339HEAT 1Add
BLAST
Repeati384 – 42239HEAT 2Add
BLAST
Repeati502 – 54039HEAT 3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili788 – 81730Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi634 – 66532Asp-richAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 3 HEAT repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG082065.
KOiK08876.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q561M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFWSRDPAR DFPYDVTGER EELPGGWGIQ KGKKKTGGDP VSVFTYEIRP
60 70 80 90 100
GAEEQTQAAK TASKRIKTLK HPNILSYVDG LETDKCLYIV TEPVTPLETY
110 120 130 140 150
VKLRTDSGGV SELEISWGLH QIVKALSFLV NDGNLIHNNV CMSAVFVDRA
160 170 180 190 200
GEWKLGGLDY MYTAGAENTA PRKGVEMEKY NPPEKTDRSK TSKEKWSADM
210 220 230 240 250
WCLGCLIWEV FNGPLPRPTA LRSLGKIAKS LVPHYCELVG ANPKIRPNPS
260 270 280 290 300
RFLQNCRSPG GFFCNSFVET NLFLEEIQIK DPAEKQTFFE QLSENLDSFP
310 320 330 340 350
EDFCRHKILP QLLTAFEFGS AGAVVLPPLF KIGKFLNADE YQQKIIPVVV
360 370 380 390 400
KMFSSTDRAM RIRLLQQMEN FIQYLNEPTV NAQIFPHVVH GFMDTNPAIR
410 420 430 440 450
EQTVKSMLLL APKLNENNLN MDLMKHFARL QARDDQGPIR CNTTVCLGKI
460 470 480 490 500
APYLNPATRQ RVLISAFSRA TKDPFAPSRA AGVLGFAATH NFYSMADCAG
510 520 530 540 550
KVLPVLCGVT LDPEKNVREQ AFKTIRSFLD KLETVSGDPS QLAELEKDVH
560 570 580 590 600
TASASPSVVG GWAGWAVTGV SSLTSKFIRT GGGAQDASPS EGAPAPPATI
610 620 630 640 650
EASKPDTVPS PSAPPAASTT PSSYEPEEEK GASDSLDRWD DEDWGSLEDT
660 670 680 690 700
DQSKGQTVND DWDTDWGQSK TQQKTVHSSS SSSKGEQVLH PPNKTSALDD
710 720 730 740 750
GWGWDDAFPT VPPAKKPTAS KSQQPEEGTR PASDYNWESP GTAGQQGDFF
760 770 780 790 800
TTLSEHSSQK TDDSRNSDSP GDWGGEDNWE SVEADQGLSK AEIARKKREE
810 820
RQKEIEAKRA ERRAAKGPLK LGVRKLD
Length:827
Mass (Da):91,303
Last modified:May 10, 2005 - v1
Checksum:i1D72BC52BE565FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074449 mRNA. Translation: AAH74449.1.
BC093531 mRNA. Translation: AAH93531.1.
RefSeqiNP_001085304.1. NM_001091835.1.
UniGeneiXl.32844.

Genome annotation databases

GeneIDi443710.
KEGGixla:443710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074449 mRNA. Translation: AAH74449.1.
BC093531 mRNA. Translation: AAH93531.1.
RefSeqiNP_001085304.1. NM_001091835.1.
UniGeneiXl.32844.

3D structure databases

ProteinModelPortaliQ561M0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi101874. 1 interaction.
IntActiQ561M0. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443710.
KEGGixla:443710.

Organism-specific databases

CTDi57410.
XenbaseiXB-GENE-5843636. scyl1.

Phylogenomic databases

HOVERGENiHBG082065.
KOiK08876.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCYL1_XENLA
AccessioniPrimary (citable) accession number: Q561M0
Secondary accession number(s): Q6DKA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.