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Q561L5

- P3F1B_XENLA

UniProt

Q561L5 - P3F1B_XENLA

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Protein

POU domain, class 3, transcription factor 1-B

Gene

pou3f1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in neuronal differentiation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi286 – 34560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. nervous system development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1-B
Alternative name(s):
Homeotic protein NRL-341 Publication
Short name:
XlNRL-34
Homeotic protein NRL-34-A
Gene namesi
Name:pou3f1-b
Synonyms:nrl-341 Publication, nrl34-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866479. pou3f1.

Subcellular locationi

Nucleus By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375POU domain, class 3, transcription factor 1-BPRO_0000389614Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ561L5.
SMRiQ561L5. Positions 200-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 26875POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 19192His-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-3 subfamily.Sequence Analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.
KOiK09365.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q561L5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT
60 70 80 90 100
NAGHPMSLTH HQWLPNPTSD WGSGSHLGAQ AEHGKSGVQS SREDLSSSFH
110 120 130 140 150
HHRSHLVHQQ TPSSHAWAQS GGHHLPSMSP GSNSHQPLIY SQSSYTNLNG
160 170 180 190 200
MLGPQASSLH HSMRDPLHDD PGVHDTHVES PPQHLGHHQD HSDEDAPSSD
210 220 230 240 250
DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF
260 270 280 290 300
KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA
310 320 330 340 350
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP
360 370
HPPMEDVYSQ AETPPLHHTL QTSVQ
Length:375
Mass (Da):41,860
Last modified:May 10, 2005 - v1
Checksum:i33DB834E1D5C1257
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC093556 mRNA. Translation: AAH93556.1.
X54684 mRNA. Translation: CAA38498.1.
RefSeqiNP_001096655.1. NM_001103185.1.
UniGeneiXl.21449.

Genome annotation databases

GeneIDi378582.
KEGGixla:378582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC093556 mRNA. Translation: AAH93556.1 .
X54684 mRNA. Translation: CAA38498.1 .
RefSeqi NP_001096655.1. NM_001103185.1.
UniGenei Xl.21449.

3D structure databases

ProteinModelPortali Q561L5.
SMRi Q561L5. Positions 200-346.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378582.
KEGGi xla:378582.

Organism-specific databases

CTDi 378582.
Xenbasei XB-GENE-866479. pou3f1.

Phylogenomic databases

HOVERGENi HBG053120.
KOi K09365.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EyeImported.
  2. "Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula embryos."
    Baltzinger M., Stiegler P., Remy P.
    Nucleic Acids Res. 18:6131-6131(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 220-324.
    Tissue: Neurula1 Publication.

Entry informationi

Entry nameiP3F1B_XENLA
AccessioniPrimary (citable) accession number: Q561L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3