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Q561L5 (P3F1B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 1-B
Alternative name(s):
Homeotic protein NRL-34
Short name=XlNRL-34
Homeotic protein NRL-34-A
Gene names
Name:pou3f1-b
Synonyms:nrl-34, nrl34-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in neuronal differentiation By similarity. UniProtKB P31363

Subcellular location

Nucleus By similarity UniProtKB P31361.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processNeurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processnervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375POU domain, class 3, transcription factor 1-B
PRO_0000389614

Regions

Domain194 – 26875POU-specific
DNA binding286 – 34560Homeobox
Compositional bias100 – 19192His-rich

Sequences

Sequence LengthMass (Da)Tools
Q561L5 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 33DB834E1D5C1257

FASTA37541,860
        10         20         30         40         50         60 
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT NAGHPMSLTH 

        70         80         90        100        110        120 
HQWLPNPTSD WGSGSHLGAQ AEHGKSGVQS SREDLSSSFH HHRSHLVHQQ TPSSHAWAQS 

       130        140        150        160        170        180 
GGHHLPSMSP GSNSHQPLIY SQSSYTNLNG MLGPQASSLH HSMRDPLHDD PGVHDTHVES 

       190        200        210        220        230        240 
PPQHLGHHQD HSDEDAPSSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI 

       250        260        270        280        290        300 
CRFEALQLSF KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA 

       310        320        330        340        350        360 
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP HPPMEDVYSQ 

       370 
AETPPLHHTL QTSVQ 

« Hide

References

« Hide 'large scale' references
[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[2]"Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula embryos."
Baltzinger M., Stiegler P., Remy P.
Nucleic Acids Res. 18:6131-6131(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 220-324.
Tissue: Neurula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC093556 mRNA. Translation: AAH93556.1.
X54684 mRNA. Translation: CAA38498.1.
RefSeqNP_001096655.1. NM_001103185.1.
UniGeneXl.21449.

3D structure databases

ProteinModelPortalQ561L5.
SMRQ561L5. Positions 200-346.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID378582.
KEGGxla:378582.

Organism-specific databases

CTD378582.
XenbaseXB-GENE-866479. pou3f1.

Phylogenomic databases

HOVERGENHBG053120.
KOK09365.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP3F1B_XENLA
AccessionPrimary (citable) accession number: Q561L5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: May 10, 2005
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families