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Protein
Submitted name:

Ketoreductase

Gene
N/A
Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16083.

Names & Taxonomyi

Protein namesi
Submitted name:
KetoreductaseImported
OrganismiStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)Imported
Taxonomic identifieri953739 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3019HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ56166.
SMRiQ56166. Positions 7-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQEKQEKR VALVTGATSG IGLAVARLLA SQNHRVFLGA RNAENVAATV
60 70 80 90 100
KQLQDEGLEV DGTTLDVRSG EDVKAFVQAA VDRFGTVELL VNNAGRSGAG
110 120 130 140 150
VTADIADELW NDVIDTNLNC VFRLTREALT TGGMREKSRG RIINMASTAG
160 170 180 190 200
KQGVVLGAPY SASKHGVVGF TKALGNELAP TGITVNAVCP GYVETPMAQR
210 220 230 240 250
VRQGYAAAYE TSEDAILEKF QSKIPLGRYS TPEEVAGLVG YLASDTAASI
260
TSQALNVCGG LGNF
Length:264
Mass (Da):27,708
Last modified:November 1, 1996 - v1
Checksum:i032E7585EC95DEF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126429 Genomic DNA. Translation: AAB36565.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126429 Genomic DNA. Translation: AAB36565.1.

3D structure databases

ProteinModelPortaliQ56166.
SMRiQ56166. Positions 7-264.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16083.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230."
    Han L., Yang K., Ramalingam E., Mosher R.H., Vining L.C.
    Microbiology 140:3379-3389(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ISP 5230Imported.
  2. "Functional characterization of the jadI gene as a cyclase forming angucyclinones."
    Kulowski K., Wendt-Pienkowski E., Han L., Yang K., Vining L.C., Hutchinson C.R.
    J. Am. Chem. Soc. 121:1786-1794(1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ISP 5230Imported.

Entry informationi

Entry nameiQ56166_STRVP
AccessioniPrimary (citable) accession number: Q56166
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.