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Protein

Cell invasion protein SipB

Gene

sipB

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE (By similarity).By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Cell invasion protein SipB
Alternative name(s):
Effector protein SipB
Gene namesi
Name:sipB
Ordered Locus Names:STY3008, t2787
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei320 – 354HelicalBy similarityAdd BLAST35
Transmembranei408 – 427HelicalBy similarityAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002198551 – 593Cell invasion protein SipBAdd BLAST593

Interactioni

Subunit structurei

Homotrimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Casp1P294522EBI-489689,EBI-489700From Mus musculus.

Protein-protein interaction databases

IntActiQ56134, 1 interactor
STRINGi220341.STY3008

Structurei

3D structure databases

SMRiQ56134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili151 – 208Sequence analysisAdd BLAST58
Coiled coili287 – 314Sequence analysisAdd BLAST28

Domaini

SipB membrane integration requires both hydrophobic domains and the helical C-terminal region.By similarity

Sequence similaritiesi

Belongs to the invasin protein B family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106H1J Bacteria
ENOG410XWFQ LUCA
HOGENOMiHOG000028231
KOiK13285
OMAiRNATATF

Family and domain databases

InterProiView protein in InterPro
IPR032391 SipB_N
IPR006972 SseC
IPR003895 T3SS_invasion_prot_B
PfamiView protein in Pfam
PF04888 SseC, 1 hit
PF16535 T3SSipB, 1 hit
PRINTSiPR01375 BACINVASINB

Sequencei

Sequence statusi: Complete.

Q56134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNDASSISR SGYTQNPRLA EAAFEGVRKN TDFLKAADKA FKDVVATKAG
60 70 80 90 100
DLKAGTKSGE SAINTVGLKP PTDAAREKLS SEGQLTLLLG KLMTLLGDVS
110 120 130 140 150
LSQLESRLAV WQAMIESQKE MGIQVSKEFQ TALGEAQEAT DLYEASIKKT
160 170 180 190 200
DTAKSVYDAA AKKLTQAQNK LQSLDPADPG YAQAEAAVEQ AGKEATEAKE
210 220 230 240 250
ALDKATDATV KAGTDAKAKA EKADNILTKF QGTANAASQN QVSQGEQDNL
260 270 280 290 300
SNVARLTMLM AMFIEIVGKN TEESLQNDLA LFNALQEGRQ AEMEKKSAEF
310 320 330 340 350
QEETRKAEET NRIMGCIGKV LGALLTIVSV VAAVFTGGAS LALAAVGLAV
360 370 380 390 400
MVADEIVKAA TGVSFIQQAL NPIMEHVLKP LMELIGKAIT KALEGLGVDK
410 420 430 440 450
KTAEMAGSIV GAIVAAIAMV AVIVVVAVVG KGAAAKLGNA LSKMMGETIK
460 470 480 490 500
KLVPNVLKQL AQNGSKLFTQ GMQRITSGLG NVGSKMGLQT NALSKELVGN
510 520 530 540 550
TLNKVALGME VTNTAAQSAG GVAEGVFIKN ASEALADFML ARFAMDQIQQ
560 570 580 590
WLKQSVEIFG ENQKVTAELQ KAMSSAVQQN ADASRFILRQ SRA
Length:593
Mass (Da):62,421
Last modified:November 1, 1996 - v1
Checksum:i8570D64343276639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82670 Genomic DNA Translation: CAA57988.1
AL513382 Genomic DNA Translation: CAD05992.1
AE014613 Genomic DNA Translation: AAO70348.1
PIRiS70216
RefSeqiNP_457279.1, NC_003198.1
WP_000245782.1, NZ_PHKG01000005.1

Genome annotation databases

EnsemblBacteriaiAAO70348; AAO70348; t2787
CAD05992; CAD05992; CAD05992
GeneIDi1249314
KEGGistt:t2787
sty:STY3008
PATRICifig|220341.7.peg.3062

Similar proteinsi

Entry informationi

Entry nameiSIPB_SALTI
AccessioniPrimary (citable) accession number: Q56134
Secondary accession number(s): Q7AME0, Q7C7N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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