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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Streptococcus thermophilus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei4PhosphateBy similarity1
Binding sitei23Phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-type (EC:2.4.2.1)
Short name:
PNP
Gene namesi
Name:deoD
OrganismiStreptococcus thermophilus
Taxonomic identifieri1308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000063166‹1 – 216Purine nucleoside phosphorylase DeoD-typeAdd BLAST›216

Proteomic databases

PRIDEiQ56037.

Interactioni

Subunit structurei

Homohexamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ56037.
SMRiQ56037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 70Phosphate bindingBy similarity4
Regioni159 – 161Purine nucleoside bindingBy similarity3
Regioni183 – 184Purine nucleoside bindingBy similarity2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR004402. DeoD-type.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
PANTHERiPTHR43691:SF1. PTHR43691:SF1. 1 hit.
PfamiView protein in Pfam
PF01048. PNP_UDP_1. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiView protein in PROSITE
PS01232. PNP_UDP_1. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q56037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DPLRAKFIAE NFLEDAVCFN EVRNMFGYTG TYKGERISVM GTGMGMPSIS
60 70 80 90 100
IYARELIVDY GVKKLIRVGT AGSLNENVHV RELVLAQAAA TNSNIIRNDW
110 120 130 140 150
PQYDFPQIAS FNLLDKAYHI AKNFGMTTHV GNVLSSDEKY SNYFEKNIEL
160 170 180 190 200
GKWGVKAVEM EAAALYYLAA QHQVDALAIM TISDSLVNPD EDTTAEERQN
210
TFTDMMKVGL ETLIAD
Length:216
Mass (Da):24,095
Last modified:November 1, 1997 - v1
Checksum:i1BBC374D174CD5B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40830 Genomic DNA. Translation: AAC44007.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDEOD_STRTR
AccessioniPrimary (citable) accession number: Q56037
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families