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Protein

Cell invasion protein SipD

Gene

sipD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2899-MONOMER.

Protein family/group databases

TCDBi1.C.36.3.2. the bacterial type iii-target cell pore (iiitcp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell invasion protein SipD
Alternative name(s):
Salmonella invasion protein D
Gene namesi
Name:sipD
Synonyms:sspD
Ordered Locus Names:STM2883
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Secreted 1 Publication

  • Note: Secreted via the type III secretion system 1 (SPI-1 TTSS).

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Cell invasion protein SipDPRO_0000219865Add
BLAST

Proteomic databases

PaxDbiQ56026.
PRIDEiQ56026.

Expressioni

Inductioni

Transcriptionally regulated by SicA and InvF. Also regulated by InvE.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2883.

Structurei

Secondary structure

1
343
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi41 – 6424Combined sources
Helixi70 – 9223Combined sources
Helixi99 – 10810Combined sources
Turni115 – 1173Combined sources
Helixi133 – 14816Combined sources
Helixi150 – 17122Combined sources
Helixi172 – 1776Combined sources
Beta strandi178 – 1803Combined sources
Helixi182 – 1843Combined sources
Beta strandi186 – 1894Combined sources
Helixi191 – 20515Combined sources
Turni210 – 2123Combined sources
Beta strandi213 – 2164Combined sources
Beta strandi220 – 2223Combined sources
Helixi228 – 23811Combined sources
Helixi242 – 2443Combined sources
Beta strandi245 – 2484Combined sources
Beta strandi251 – 2555Combined sources
Helixi259 – 27012Combined sources
Beta strandi275 – 2784Combined sources
Beta strandi280 – 2834Combined sources
Helixi284 – 33855Combined sources
Helixi339 – 3424Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YM0X-ray3.00A/B132-343[»]
2YM9X-ray3.00A/B/C/D1-343[»]
3NZZX-ray1.65A/B39-343[»]
3O00X-ray1.85A/B39-343[»]
3O01X-ray1.90A/B39-343[»]
3O02X-ray1.90A/B39-343[»]
3ZQBX-ray2.40A/B127-343[»]
3ZQEX-ray2.19A/B127-343[»]
ProteinModelPortaliQ56026.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56026.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili295 – 32228Sequence analysisAdd
BLAST

Domaini

The N-terminal domain is an intra-molecular chaperone that prevents premature oligomerization of the residues on the coiled-coil region that are involved in interactions with the needle and/or itself. The residues in the C-terminal domain probably form oligomeric structures at the tip of the needle that are responsible for the regulation of secretion of other effectors (By similarity).By similarity

Sequence similaritiesi

Belongs to the invasin protein D family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105IBT. Bacteria.
ENOG4111P3X. LUCA.
HOGENOMiHOG000028233.
KOiK13287.
OMAiNYLGVYE.

Family and domain databases

InterProiIPR009483. Plasmid_invsIpaD.
IPR013386. T3SS_IpaD/SipD/SspD.
[Graphical view]
PfamiPF06511. IpaD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02553. SipD_IpaD_SspD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q56026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNIQNYSAS PHPGIVAERP QTPSASEHVE TAVVPSTTEH RGTDIISLSQ
60 70 80 90 100
AATKIHQAQQ TLQSTPPISE ENNDERTLAR QQLTSSLNAL AKSGVSLSAE
110 120 130 140 150
QNENLRSAFS APTSALFSAS PMAQPRTTIS DAEIWDMVSQ NISAIGDSYL
160 170 180 190 200
GVYENVVAVY TDFYQAFSDI LSKMGGWLLP GKDGNTVKLD VTSLKNDLNS
210 220 230 240 250
LVNKYNQINS NTVLFPAQSG SGVKVATEAE ARQWLSELNL PNSCLKSYGS
260 270 280 290 300
GYVVTVDLTP LQKMVQDIDG LGAPGKDSKL EMDNAKYQAW QSGFKAQEEN
310 320 330 340
MKTTLQTLTQ KYSNANSLYD NLVKVLSSTI SSSLETAKSF LQG
Length:343
Mass (Da):37,112
Last modified:November 1, 1996 - v1
Checksum:i4B8E46419114219F
GO

Sequence cautioni

The sequence AAA86617 differs from that shown. Reason: Frameshift at position 333. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921S → A in AAA86617 (PubMed:8522512).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30491 Genomic DNA. Translation: AAC43548.1.
U40013 Genomic DNA. Translation: AAA86617.1. Frameshift.
AE006468 Genomic DNA. Translation: AAL21763.1.
PIRiS70549.
RefSeqiNP_461804.1. NC_003197.1.
WP_000932246.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21763; AAL21763; STM2883.
GeneIDi1254406.
KEGGistm:STM2883.
PATRICi32384454. VBISalEnt20916_3039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30491 Genomic DNA. Translation: AAC43548.1.
U40013 Genomic DNA. Translation: AAA86617.1. Frameshift.
AE006468 Genomic DNA. Translation: AAL21763.1.
PIRiS70549.
RefSeqiNP_461804.1. NC_003197.1.
WP_000932246.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YM0X-ray3.00A/B132-343[»]
2YM9X-ray3.00A/B/C/D1-343[»]
3NZZX-ray1.65A/B39-343[»]
3O00X-ray1.85A/B39-343[»]
3O01X-ray1.90A/B39-343[»]
3O02X-ray1.90A/B39-343[»]
3ZQBX-ray2.40A/B127-343[»]
3ZQEX-ray2.19A/B127-343[»]
ProteinModelPortaliQ56026.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2883.

Protein family/group databases

TCDBi1.C.36.3.2. the bacterial type iii-target cell pore (iiitcp) family.

Proteomic databases

PaxDbiQ56026.
PRIDEiQ56026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21763; AAL21763; STM2883.
GeneIDi1254406.
KEGGistm:STM2883.
PATRICi32384454. VBISalEnt20916_3039.

Phylogenomic databases

eggNOGiENOG4105IBT. Bacteria.
ENOG4111P3X. LUCA.
HOGENOMiHOG000028233.
KOiK13287.
OMAiNYLGVYE.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2899-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ56026.

Family and domain databases

InterProiIPR009483. Plasmid_invsIpaD.
IPR013386. T3SS_IpaD/SipD/SspD.
[Graphical view]
PfamiPF06511. IpaD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02553. SipD_IpaD_SspD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIPD_SALTY
AccessioniPrimary (citable) accession number: Q56026
Secondary accession number(s): Q56033, Q7CPX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.