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Protein

Cell invasion protein SipB

Gene

sipB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE.2 Publications

GO - Biological processi

  • pathogenesis Source: UniProtKB-KW
  • protein localization to Golgi apparatus Source: AgBase

Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2913-MONOMER

Protein family/group databases

TCDBi1.C.36.3.2 the bacterial type iii-target cell pore (iiitcp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cell invasion protein SipB
Alternative name(s):
Effector protein SipB
Gene namesi
Name:sipB
Synonyms:sspB
Ordered Locus Names:STM2885
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei320 – 354HelicalAdd BLAST35
Transmembranei408 – 427HelicalAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002198561 – 593Cell invasion protein SipBAdd BLAST593

Proteomic databases

PaxDbiQ56019
PRIDEiQ56019

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

STRINGi99287.STM2885

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi85 – 99Combined sources15
Helixi101 – 118Combined sources18
Turni119 – 122Combined sources4
Helixi129 – 171Combined sources43
Helixi183 – 221Combined sources39

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TULX-ray2.79A/B/C/D81-237[»]
SMRiQ56019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili151 – 208Sequence analysisAdd BLAST58
Coiled coili287 – 314Sequence analysisAdd BLAST28

Domaini

SipB membrane integration requires both hydrophobic domains and the helical C-terminal region.

Sequence similaritiesi

Belongs to the invasin protein B family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106H1J Bacteria
ENOG410XWFQ LUCA
HOGENOMiHOG000028231
KOiK13285
OMAiRNATATF

Family and domain databases

InterProiView protein in InterPro
IPR032391 SipB_N
IPR006972 SseC
IPR003895 T3SS_invasion_prot_B
PfamiView protein in Pfam
PF04888 SseC, 1 hit
PF16535 T3SSipB, 1 hit
PRINTSiPR01375 BACINVASINB

Sequencei

Sequence statusi: Complete.

Q56019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNDASSISR SGYTQNPRLA EAAFEGVRKN TDFLKAADKA FKDVVATKAG
60 70 80 90 100
DLKAGTKSGE SAINTVGLKP PTDAAREKLS SEGQLTLLLG KLMTLLGDVS
110 120 130 140 150
LSQLESRLAV WQAMIESQKE MGIQVSKEFQ TALGEAQEAT DLYEASIKKT
160 170 180 190 200
DTAKSVYDAA TKKLTQAQNK LQSLDPADPG YAQAEAAVEQ AGKEATEAKE
210 220 230 240 250
ALDKATDATV KAGTDAKAKA EKADNILTKF QGTANAASQN QVSQGEQDNL
260 270 280 290 300
SNVARLTMLM AMFIEIVGKN TEESLQNDLA LFNALQEGRQ AEMEKKSAEF
310 320 330 340 350
QEETRKAEET NRIMGCIGKV LGALLTIVSV VAAVFTGGAS LALAAVGLAV
360 370 380 390 400
MVADEIVKAA TGVSFIQQAL NPIMEHVLKP LMELIGKAIT KALEGLGVDK
410 420 430 440 450
KTAEMAGSIV GAIVAAIAMV AVIVVVAVVG KGAAAKLGNA LSKMMGETIK
460 470 480 490 500
KLVPNVLKQL AQNGSKLFTQ GMQRITSGLG NVGSKMGLQT NALSKELVGN
510 520 530 540 550
TLNKVALGME VTNTAAQSAG GVAEGVFIKN ASEALADFML ARFAMDQIQQ
560 570 580 590
WLKQSVEIFG ENQKVTAELQ KAMSSAVQQN ADASRFILRQ SRA
Length:593
Mass (Da):62,451
Last modified:November 1, 1996 - v1
Checksum:i63A5D5949D85BA46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25631 Genomic DNA Translation: AAA75169.1
AE006468 Genomic DNA Translation: AAL21765.1
U30491 Genomic DNA Translation: AAC43546.1
PIRiS70547
RefSeqiNP_461806.1, NC_003197.2
WP_000245788.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21765; AAL21765; STM2885
GeneIDi1254408
KEGGistm:STM2885
PATRICifig|99287.12.peg.3041

Similar proteinsi

Entry informationi

Entry nameiSIPB_SALTY
AccessioniPrimary (citable) accession number: Q56019
Secondary accession number(s): Q56024, Q7CPX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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