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Protein

Catalase

Gene

CNBA5410

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.UniRule annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotation

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
  2. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotation

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
Gene namesi
Ordered Locus Names:CNBA5410Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)Imported
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000001435 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:CNBA5410.

Structurei

3D structure databases

ProteinModelPortaliQ55ZE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.UniRule annotation

Phylogenomic databases

KOiK03781.
OrthoDBiEOG7K9KBN.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
IPR029062. Class_I_gatase-like.
IPR002818. ThiJ/PfpI.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
PF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 2 hits.
SSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55ZE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTGDAKYRQ MAEYTIDQDD KTPYTTYFGV KVSDTDNSLR AGARGPTLLE
60 70 80 90 100
DFHNREKIQH FDHERIPERV VHARGAGAFG EFKLHTPLTG ITTAKVLTDT
110 120 130 140 150
SKVVPAYVRF STVAGSRGSA DTVRDVRGFA TRLYTDEGNW DIVGNNIPVF
160 170 180 190 200
FINAQTAHDN AWDFMSLHKP ALHMQQWITS DRAIPRSYRM MQGFGVHTFR
210 220 230 240 250
LINEEGKSTF VKYHWIPHLG THSLVWDEAL KIAGQDPDFH RRDLWDAIEA
260 270 280 290 300
GTYAKWDLGV QLIKEEDEHK FDFDLLDATK LIPDELVPVQ KIGTLTLNRN
310 320 330 340 350
PVDYFSEVEQ VAFCTQHIVP GMDFTDDPLL AGRNFSYPDT QVSRLGINWK
360 370 380 390 400
HIPVNRPVCP FMTTMREGQM SMFSKNNRTP YHPNRNENLP LTSPKEGGFK
410 420 430 440 450
SYPAKVSGIK ERVQAPKFND HSSQATLFWN SMSDVEKKHI IDAYKFELSH
460 470 480 490 500
CTDNLVIQNV INCINEIDHG LATAVHSGFP HLSLPEAKPN HGKRTEYLSQ
510 520 530 540 550
ITGKNQIFTA AGRKIGIFLV PGYVYSQVAP LLAAFKAAGC MVKFVGPTLG
560 570 580 590 600
PVEASDGQSF TTEFTFEGCR STYFDALIFA GGPDNAFLSK LKVGRLIHAA
610 620 630 640 650
REAYMHLKAV GAVGNATQWL VDTCLPGEFS PKVKTESSVV QENGVVFAPI
660 670 680
NPTLHSAQFA KQFLDGVANH RVWDREVSHI AA
Length:682
Mass (Da):76,378
Last modified:May 24, 2005 - v1
Checksum:iE745DB22E5B2AEF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000003 Genomic DNA. Translation: EAL23197.1.
RefSeqiXP_777844.1. XM_772751.1.

Genome annotation databases

GeneIDi4933804.
KEGGicnb:CNBA5410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000003 Genomic DNA. Translation: EAL23197.1.
RefSeqiXP_777844.1. XM_772751.1.

3D structure databases

ProteinModelPortaliQ55ZE8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4933804.
KEGGicnb:CNBA5410.

Organism-specific databases

EuPathDBiFungiDB:CNBA5410.

Phylogenomic databases

KOiK03781.
OrthoDBiEOG7K9KBN.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
IPR029062. Class_I_gatase-like.
IPR002818. ThiJ/PfpI.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
PF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 2 hits.
SSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B-3501AImported.

Entry informationi

Entry nameiQ55ZE8_CRYNB
AccessioniPrimary (citable) accession number: Q55ZE8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.