JmjC domain-containing histone demethylation protein 1

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1

Gene names

Name:	JHD1
Ordered Locus Names:	CNG00620, CNBG4160

Organism

Cryptococcus neoformans (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

5207 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

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Protein attributes

Sequence length	879 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.
Catalytic activity	Protein N₆,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O₂ = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO₂. Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O₂ = protein L-lysine + succinate + formaldehyde + CO₂.
Cofactor	Binds 1 Fe²⁺ ion per subunit By similarity.
Subcellular location	Nucleus By similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain. Contains 1 PHD-type zinc finger.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 879

879

JmjC domain-containing histone demethylation protein 1

PRO_0000226795

Regions

Domain

416 – 598

183

JmjC

Zinc finger

23 – 116

94

PHD-type

Sites

Metal binding

475

1

Iron; catalytic By similarity

Metal binding

477

1

Iron; catalytic By similarity

Metal binding

566

1

Iron; catalytic By similarity

Binding site

472

1

Substrate By similarity

Binding site

492

1

Substrate By similarity

Natural variations

Natural variant

401

1

N → S in strain: B-3501A.

Natural variant

421

1

G → S in strain: B-3501A.

Natural variant

620

1

E → D in strain: B-3501A.

Natural variant

854

1

I → V in strain: B-3501A.

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Sequences

Sequence

Length

Mass (Da)

Tools

Q55NZ6-1 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: 2FF7F5CE7547B6EA
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FASTA

879

98,240

        10         20         30         40         50         60 
MSEQVGQREA VDSPQATGVK TPPEPCPLCR ETGPPQPPSI TEEGKTNEDI DFIWVACNKC 

        70         80         90        100        110        120 
DEWYHSACLF LGDEKWRGTI PKEIISTVET NFGDEGAWTN WVEWIGKWYC APCLARSTSP 

       130        140        150        160        170        180 
SNPRPPRHPL VATMKRASIQ PKDIDQAGKP LKRSASTSAP LLKSNIKRPR TSTKGQETAS 

       190        200        210        220        230        240 
PEIDMKSERE QQAESTAGTP ASDAPQGRPK RKTAQIDYRN LNNSIATPTH QWLELIADPE 

       250        260        270        280        290        300 
KYGRTILDAN YPALPGKLLT RAWLESQPLP GQPSSISPDL LPTRFWGPDR EPLIVRPENG 

       310        320        330        340        350        360 
GFSSLGGHLP SKDLTVQDVA NLVGPDRMVD VIDVSSQHSS QWTLQKWAEY IQSSSGNTSV 

       370        380        390        400        410        420 
RNPKVYNVIS LEISGTELAK KVKPPKIVRE IDWVDNFWRF NAGAGGKDVK EKGRGNDSRE 

       430        440        450        460        470        480 
GSEIRKEGSH LTEGDNAGGE IEEDLEGLKE KTNTPYPKVQ LYCLMGMKGA WTDWHVDFAA 

       490        500        510        520        530        540 
SSVYYTIHSG AKVKLSCFVS FFSPGSYHSQ VFFFVKPTEQ NLKAYAEWSG SYEKQQDTWL 

       550        560        570        580        590        600 
GDMVDEVRKV ELHAGDTMII PTGYIHAVYT PMDSIVFGGN FLHSYNVDTQ LRLRQIEIDT 

       610        620        630        640        650        660 
KVPQRFRFPM FDRLCWYVAE KYCSDLRHLR AYRPRATTTP KPPHFRVLQC LSYLANFLVS 

       670        680        690        700        710        720 
QTGILEDPEA EDKARKLVHD RIPGDIVKDP EGLAKELKWR VERELGALGL LGEEASGVEA 

       730        740        750        760        770        780 
EEFKSNGTAN GSVKIKGKEV SRKRDRLSKV FDKKAISRTW DFHPPAWSEN RQSPQIETTT 

       790        800        810        820        830        840 
VQLPRPSTSS SDAISGSGPG ASPGASANGG ANENEQAELT TMLVKQTRKR MRELDDGTVI 

       850        860        870 
EESQETTFVE KKTIWGPKLD KEKISQPQGK VEEDMDIDH

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References

[1]

"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.

Hyman R.W.
Science 307:1321-1324(2005) [PubMed: 15653466] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B-3501A and JEC21.

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Cross-references

Sequence databases
	AE017347 Genomic DNA. Translation: AAW44468.1. Sequence problems. AAEY01000039 Genomic DNA. Translation: EAL19469.1.
RefSeq	XP_571775.1. XP_774116.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3258972. 4937452.
GenomeReviews	Gene locus CNG00620 in contig AE017347_GR.
KEGG	cnb:CNBG4160. cne:CNG00620.
Phylogenomic databases
HOGENOM	Q55NZ6.
Enzyme and pathway databases
BRENDA	1.14.11.27. 2772.
Family and domain databases
InterPro	IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR019786. Zinc_finger_PHD-type_CS. IPR001965. Znf_PHD. [Graphical view]
Pfam	PF02373. JmjC. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. False negative. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

JHD1_CRYNE

Accession

Primary (citable) accession number: Q55NZ6
Secondary accession number(s): Q5KEG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 27 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents