Q55GS4 (CDK10_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cyclin-dependent kinase 10
EC=2.7.11.22

Gene names

Name:	cdk10
ORF Names:	DDB_G0268480

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Induction	Up-regulated by Pseudomonas aeruginosa, PA14 strain infection but not by Pseudomonas aeruginosa, PA01 strain.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: dictyBase nucleus Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Probable cyclin-dependent kinase 10		PRO_0000353100
Regions
	Domain	7 – 293	287	Protein kinase
	Nucleotide binding	13 – 21	9	ATP By similarity
	Compositional bias	317 – 358	42	Asn-rich
Sites
	Active site	132	1	Proton acceptor By similarity
	Binding site	36	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55GS4 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 5F231B25CA0310E3	FASTA	366	41,964
	10 20 30 40 50 60 MRSVLSFEKL DSIGEGTYGI VSKGRDKETG RIVALKKVKI GQQDKDGIPL TSLREIQILK 70 80 90 100 110 120 EIKHPNIVSL LEVVIGSTGD KIYLVFEYLE HDVASLIDNI NKPFKLSEIK CFLLQLLRAV 130 140 150 160 170 180 EYLHSHWIIH RDLKCSNLLY GNNGNLKLAD FGLARKFGYP IESITPCMVT LWYRSPELLL 190 200 210 220 230 240 GCQKYSTAVD LWSIGSIFGE LLIGRPLITG NNEVDQIMRI FNLLGEPNEQ IWPGFSSLPN 250 260 270 280 290 300 FKRLNNIPHQ PYNNLRELVP TISDTAFDLL NQLLTYDPTK RITASDAIKH PFFYENPFPQ 310 320 330 340 350 360 SIEMMPKFPT ISKSFKNQNK KQNNNFNNFV QNNQTNQNNQ TNQNNQTNQN NKTSQNNNMD SYKYSK

References

[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains." Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R., Ivens A., Martinez J.L., Escalante R. BMC Microbiol. 8:109-109(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000003 Genomic DNA. Translation: EAL73693.1.
RefSeq	XP_647110.1. XM_642018.1.
3D structure databases
ProteinModelPortal	Q55GS4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0229427; DDB0229427; DDB_G0268480.
GeneID	8615914.
KEGG	ddi:DDB_G0268480.
Organism-specific databases
dictyBase	DDB_G0268480. cdk10.
Phylogenomic databases
eggNOG	COG0515.
OMA	ANRISAR.
ProtClustDB	CLSZ2430383.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK10_DICDI

Accession

Primary (citable) accession number: Q55GS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	May 24, 2005
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)