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Q55GS4 (CDK10_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cyclin-dependent kinase 10

EC=2.7.11.22
Gene names
Name:cdk10
ORF Names:DDB_G0268480
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Induction

Up-regulated by Pseudomonas aeruginosa, PA14 strain infection but not by Pseudomonas aeruginosa, PA01 strain.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Probable cyclin-dependent kinase 10
PRO_0000353100

Regions

Domain7 – 293287Protein kinase
Nucleotide binding13 – 219ATP By similarity
Compositional bias317 – 35842Asn-rich

Sites

Active site1321Proton acceptor By similarity
Binding site361ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55GS4 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 5F231B25CA0310E3

FASTA36641,964
        10         20         30         40         50         60 
MRSVLSFEKL DSIGEGTYGI VSKGRDKETG RIVALKKVKI GQQDKDGIPL TSLREIQILK 

        70         80         90        100        110        120 
EIKHPNIVSL LEVVIGSTGD KIYLVFEYLE HDVASLIDNI NKPFKLSEIK CFLLQLLRAV 

       130        140        150        160        170        180 
EYLHSHWIIH RDLKCSNLLY GNNGNLKLAD FGLARKFGYP IESITPCMVT LWYRSPELLL 

       190        200        210        220        230        240 
GCQKYSTAVD LWSIGSIFGE LLIGRPLITG NNEVDQIMRI FNLLGEPNEQ IWPGFSSLPN 

       250        260        270        280        290        300 
FKRLNNIPHQ PYNNLRELVP TISDTAFDLL NQLLTYDPTK RITASDAIKH PFFYENPFPQ 

       310        320        330        340        350        360 
SIEMMPKFPT ISKSFKNQNK KQNNNFNNFV QNNQTNQNNQ TNQNNQTNQN NKTSQNNNMD 


SYKYSK 

« Hide

References

[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains."
Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R., Ivens A., Martinez J.L., Escalante R.
BMC Microbiol. 8:109-109(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000003 Genomic DNA. Translation: EAL73693.1.

3D structure databases

ProteinModelPortalQ55GS4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0229427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0229427; DDB0229427; DDB_G0268480.
KEGGddi:DDB_G0268480.

Organism-specific databases

dictyBaseDDB_G0268480. cdk10.

Phylogenomic databases

eggNOGCOG0515.
OMARWANTEE.
PhylomeDBQ55GS4.
ProtClustDBCLSZ2430383.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ55GS4.

Entry information

Entry nameCDK10_DICDI
AccessionPrimary (citable) accession number: Q55GS4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase