ID   GYS_DICDI               Reviewed;         878 AA.
AC   Q55GH4;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=Glycogen [starch] synthase;
DE            EC=2.4.1.11 {ECO:0000269|PubMed:9023987};
GN   Name=glcS; ORFNames=DDB_G0267674;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC
RP   ACTIVITY, PATHWAY, AND BIOPHYSICOCHEMICAL PROPERTIES.
RX   PubMed=9023987;
RX   DOI=10.1002/(sici)1520-6408(1996)19:4<350::aid-dvg8>3.0.co;2-8;
RA   Williamson B.D., Favis R., Brickey D.A., Rutherford C.L.;
RT   "Isolation and characterization of glycogen synthase in Dictyostelium
RT   discoideum.";
RL   Dev. Genet. 19:350-364(1996).
RN   [2] {ECO:0000312|EMBL:EAL73290.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the formation of apha-1,4 glycosidic bonds adding
CC       glucose residue from UDPG to the growing chain of glycogen.
CC       {ECO:0000269|PubMed:9023987}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:18549, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11;
CC         Evidence={ECO:0000269|PubMed:9023987};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18550;
CC         Evidence={ECO:0000269|PubMed:9023987};
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is between 7.5 and 8.0. {ECO:0000269|PubMed:9023987};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000305|PubMed:9023987}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 3 family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73290.1; -; Genomic_DNA.
DR   RefSeq; XP_647210.1; XM_642118.1.
DR   AlphaFoldDB; Q55GH4; -.
DR   SMR; Q55GH4; -.
DR   STRING; 44689.Q55GH4; -.
DR   PaxDb; 44689-DDB0231962; -.
DR   EnsemblProtists; EAL73290; EAL73290; DDB_G0267674.
DR   GeneID; 8616014; -.
DR   KEGG; ddi:DDB_G0267674; -.
DR   dictyBase; DDB_G0267674; glcS.
DR   eggNOG; KOG3742; Eukaryota.
DR   HOGENOM; CLU_015910_1_0_1; -.
DR   InParanoid; Q55GH4; -.
DR   OMA; RDVRNHI; -.
DR   PhylomeDB; Q55GH4; -.
DR   UniPathway; UPA00164; -.
DR   PRO; PR:Q55GH4; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IDA:dictyBase.
DR   GO; GO:0000045; P:autophagosome assembly; IMP:dictyBase.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IDA:dictyBase.
DR   GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR   CDD; cd03793; GT3_GSY2-like; 1.
DR   Gene3D; 6.10.260.10; -; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR008631; Glycogen_synth.
DR   PANTHER; PTHR10176:SF3; GLYCOGEN [STARCH] SYNTHASE; 1.
DR   PANTHER; PTHR10176; GLYCOGEN SYNTHASE; 1.
DR   Pfam; PF05693; Glycogen_syn; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 2.
PE   1: Evidence at protein level;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..878
FT                   /note="Glycogen [starch] synthase"
FT                   /id="PRO_0000355639"
FT   REGION          637..721
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          746..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..721
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         61
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   878 AA;  97515 MW;  CA7F313E52021AB3 CRC64;
     MIFGTPNSTF LENRLGSSTG MPFSSATSLN SGVDQMMNEL NIQQPTSHTV LFDLSWEVAK
     KVGGIYTVLK TKAPVTVEEY KSRYALIGPY NASTAPTEFE PLIPGPLSSP IIENMMKKYG
     IHVHFGKWLV EGYPKVFLID LHSSMHKLGE WRWDLMSGFE QAGDNETNET IVFGYQSALL
     LKEFAEANPN DKYIAHFHEW QASVGLILLK KWKVPVSTIF TTHATLLGRY LAAGGVDLYN
     QMQVLNMDFE ASKRGIYHRH WIEKKSAADS HVFTTVSEIT GYESEHILMR KPDVILPNGL
     KLDKFTALHE FQNLHAKYKG VLNEFVRGHF YGHYSDFDLD NTLYVFTAGR HEYFNKGVDM
     FLDSLAGLNK LLQQSGSKMT VVAFIIMPAA TNNFNVESLK GHSYLKDMRR TCNTIVEAMG
     ERLFEATSRG KMISPEELLS QEDLVMLKRR IFALKQKSSG PPVVTHNMIN DNDEILQHIR
     RIKLFNSQED RVKVIYHPEF LTSTNPLIPL DYTEFVRGCH LGIFPSYYEP FGMTPAECCA
     SGCPSITSNL TGFANYMSRA LQDTDSKGIF IVDRRFKSSR ETVDQMTQYL WKFTQLDRRQ
     RIELRNATEK LSELLDWRTL GKFYKTARAL ALERAFPPKP ISRSPSPSPS SSLKLSTGLS
     NQIELQQQQQ QQQPQPIGTT INLIPPSSNV SVTPTTTPTT TTTATTATTA PITTPKPNVI
     PINTGKENIT LLSPNSMSSL LSDSLNEFKK QQQQQQQSKT PTTPTTTSTT TTTPSTTAAA
     TNKSVLSNPT PTPSPNTSSF IPTNKGSTAT TTTTTATPTP TPSNNTNGKP FNPIEALTKS
     NSSSNFATTS TASVNTNNGG TNSPVSKSIP IPSSKSLK
//