Q55GH4 (GYS_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycogen [starch] synthase
EC=2.4.1.11

Gene names

Name:	glcS
ORF Names:	DDB_G0267674

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	878 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the glycosyl residue from UDPG to the non-reducing end of alpha-1,4-glucan. Ref.1
Catalytic activity	UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).
Pathway	Glycan biosynthesis; glycogen biosynthesis.
Sequence similarities	Belongs to the glycosyltransferase 3 family.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	autophagic vacuole assembly Inferred from mutant phenotype. Source: dictyBase glycogen biosynthetic process Inferred from direct assay Ref.1. Source: dictyBase
Molecular function	glycogen (starch) synthase activity Inferred from direct assay Ref.1. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 878	878	Glycogen [starch] synthase		PRO_0000355639
Regions
	Compositional bias	666 – 675	10	Poly-Gln
	Compositional bias	693 – 861	169	Thr-rich
Sites
	Binding site	61	1	UDP-glucose By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55GH4 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: CA7F313E52021AB3	FASTA	878	97,515
	10 20 30 40 50 60 MIFGTPNSTF LENRLGSSTG MPFSSATSLN SGVDQMMNEL NIQQPTSHTV LFDLSWEVAK 70 80 90 100 110 120 KVGGIYTVLK TKAPVTVEEY KSRYALIGPY NASTAPTEFE PLIPGPLSSP IIENMMKKYG 130 140 150 160 170 180 IHVHFGKWLV EGYPKVFLID LHSSMHKLGE WRWDLMSGFE QAGDNETNET IVFGYQSALL 190 200 210 220 230 240 LKEFAEANPN DKYIAHFHEW QASVGLILLK KWKVPVSTIF TTHATLLGRY LAAGGVDLYN 250 260 270 280 290 300 QMQVLNMDFE ASKRGIYHRH WIEKKSAADS HVFTTVSEIT GYESEHILMR KPDVILPNGL 310 320 330 340 350 360 KLDKFTALHE FQNLHAKYKG VLNEFVRGHF YGHYSDFDLD NTLYVFTAGR HEYFNKGVDM 370 380 390 400 410 420 FLDSLAGLNK LLQQSGSKMT VVAFIIMPAA TNNFNVESLK GHSYLKDMRR TCNTIVEAMG 430 440 450 460 470 480 ERLFEATSRG KMISPEELLS QEDLVMLKRR IFALKQKSSG PPVVTHNMIN DNDEILQHIR 490 500 510 520 530 540 RIKLFNSQED RVKVIYHPEF LTSTNPLIPL DYTEFVRGCH LGIFPSYYEP FGMTPAECCA 550 560 570 580 590 600 SGCPSITSNL TGFANYMSRA LQDTDSKGIF IVDRRFKSSR ETVDQMTQYL WKFTQLDRRQ 610 620 630 640 650 660 RIELRNATEK LSELLDWRTL GKFYKTARAL ALERAFPPKP ISRSPSPSPS SSLKLSTGLS 670 680 690 700 710 720 NQIELQQQQQ QQQPQPIGTT INLIPPSSNV SVTPTTTPTT TTTATTATTA PITTPKPNVI 730 740 750 760 770 780 PINTGKENIT LLSPNSMSSL LSDSLNEFKK QQQQQQQSKT PTTPTTTSTT TTTPSTTAAA 790 800 810 820 830 840 TNKSVLSNPT PTPSPNTSSF IPTNKGSTAT TTTTTATPTP TPSNNTNGKP FNPIEALTKS 850 860 870 NSSSNFATTS TASVNTNNGG TNSPVSKSIP IPSSKSLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of glycogen synthase in Dictyostelium discoideum." Williamson B.D., Favis R., Brickey D.A., Rutherford C.L. Dev. Genet. 19:350-364(1996) [PubMed: 9023987] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE, FUNCTION.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000003 Genomic DNA. Translation: EAL73290.1.
RefSeq	XP_647210.1. XM_642118.1.
3D structure databases
ProteinModelPortal	Q55GH4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q55GH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231962; DDB0231962; DDB_G0267674.
GeneID	8616014.
GenomeReviews	Gene locus glcS in contig CM000150_GR.
KEGG	ddi:DDB_G0267674.
Organism-specific databases
dictyBase	DDB_G0267674. glcS.
Phylogenomic databases
eggNOG	KOG3742.
GeneTree	EPrGT00060000009745.
HOGENOM	HBG330297.
OMA	MINDNDE.
PhylomeDB	Q55GH4.
ProtClustDB	CLSZ2431516.
Family and domain databases
InterPro	IPR008631. Glycogen_synth. [Graphical view]
KO	K00693.
PANTHER	PTHR10176. Glycogen_synth. 1 hit.
Pfam	PF05693. Glycogen_syn. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GYS_DICDI

Accession

Primary (citable) accession number: Q55GH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)