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Protein

Probable mitochondrial 2-oxodicarboxylate carrier

Gene

mcfT

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-DDI-71064. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:mcfT
Synonyms:slc25a21
ORF Names:DDB_G0267704
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0267704. mcfT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei278 – 298Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003282821 – 300Probable mitochondrial 2-oxodicarboxylate carrierAdd BLAST300

Proteomic databases

PaxDbiQ55GE2.

Structurei

3D structure databases

ProteinModelPortaliQ55GE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 104Solcar 1Add BLAST84
Repeati114 – 200Solcar 2Add BLAST87
Repeati209 – 295Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0754. Eukaryota.
ENOG410XRZG. LUCA.
InParanoidiQ55GE2.
KOiK15110.
OMAiLESTMWR.
PhylomeDBiQ55GE2.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q55GE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKGNAGNP PTPTPAPVKS QPLWHNLVSG GIAGVSEILV MYPLDVVKTR
60 70 80 90 100
QQLQVGKGQS MMSSLVTMVR HDGLKMYRGI VPPILVEAPK RAIKFASNKF
110 120 130 140 150
YEKQILSYCG NTKPTQMQAI GSGVLAGITE AFIVVPFELV KIRLQAKENA
160 170 180 190 200
GKYTSTMDCV NKTFRAEGLS GFFKGLESTI WRHACWNGGY FGLIHTIKSA
210 220 230 240 250
LPKPTTEQGV LVNNFIAGGL AGTFGTMLNT PADVVKSRIQ NQVGAGKYNW
260 270 280 290 300
CIPSILTVAR EEGFSALYKG FLPKVLRLGP GGGILLVVNE FVMKLLAGKN
Length:300
Mass (Da):32,388
Last modified:May 24, 2005 - v1
Checksum:i5172F9BD562053CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73305.1.
RefSeqiXP_647242.1. XM_642150.1.

Genome annotation databases

EnsemblProtistsiEAL73305; EAL73305; DDB_G0267704.
GeneIDi8616047.
KEGGiddi:DDB_G0267704.

Similar proteinsi

Entry informationi

Entry nameiODC_DICDI
AccessioniPrimary (citable) accession number: Q55GE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families