Reviewed, UniProtKB/Swiss-Prot Q55G83 (ABKC_DICDI)

Names and origin

Protein names

Recommended name:
    Probable serine/threonine-protein kinase abkC
    EC=2.7.11.-

Gene names

Name:	abkC
Synonyms:	adckC
ORF Names:	DDB_G0267774

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	689 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 689	689	Probable serine/threonine-protein kinase abkC		PRO_0000367578
Regions
	Domain	257 – 689	433	Protein kinase
	Nucleotide binding	263 – 271	9	ATP By similarity
	Compositional bias	58 – 72	15	Poly-Asn
	Compositional bias	98 – 105	8	Poly-Asn
	Compositional bias	450 – 455	6	Poly-Gln
	Compositional bias	655 – 685	31	Poly-Asn
Sites
	Active site	417	1	Proton acceptor By similarity
	Binding site	285	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55G83-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 73FBD58BD9CBC0ED	FASTA	689	79,409
	10 20 30 40 50 60 MSNKQIFLKF KSGEIILNNF NKYTDSISSK LLFYQNIKNQ ENNSGNENYK NFNYNYKNKN 70 80 90 100 110 120 NYNNNNNNNN SNSSSNNNGS NNNIKFNSLF ISSIYLYNNN NSNNNDLKND KNDNSIGNIN 130 140 150 160 170 180 KIIKPKIEIQ DLLNPFEAIK EIVGNKEDEE INLVKIGIRV LELGLILLPS VLTFPCCFIP 190 200 210 220 230 240 GVKELWWQLL LETIQFSGTC WIKFGQWIST RPDLFPDLLI EKFSQLHSQC PSHSFQFTNE 250 260 270 280 290 300 SIENSFNGKS IKDLFLWFDE EPMASGSVAQ VHKALTMDGK VAVVKVLHPN VKSNIKRDFF 310 320 330 340 350 360 IIYSLIWAFS HIPEMKWLSL PESILEFGKS MMKQADLELE ASHLNRFNSN FKYNSEVIFP 370 380 390 400 410 420 KPLYPLVSKE VLVESFEPGS PIMDFIKKND HHNPTLAKIG LSAYMQMMLV DNFVHADLHP 430 440 450 460 470 480 GNVLVRTSDD DNFKSIDNNY FKKYNNDNDQ QQQQQYNLPF KRKLYDTIEK SHKKFDSMLG 490 500 510 520 530 540 GIQLKSIDFK EHQKSSPKLI FLDVGLVTQL GQQDKDHFIE LFTEIVNGNG KEGAELLIRY 550 560 570 580 590 600 AREAKCTEEE MYQFKERMGT LFNQVQNSKL SEVHVGQFMS EILGLVREYH VKIESNFATL 610 620 630 640 650 660 VMGTIVLEGL GKQLDPSLGL LKAAIPFLLK SQVFSFSNFI KDFFLKSKTS KKQLNNDNNN 670 680 NNNNNNNNKN NNDNNNKNNN NKNNNEKNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The dictyostelium kinome -- analysis of the protein kinases from a simple model organism." Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L. PLoS Genet. 2:E38-E38(2006) [PubMed: 16596165] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000003 Genomic DNA. Translation: EAL73340.1.
RefSeq	XP_647300.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q55G83.
Genome annotation databases
GeneID	3398382.
GenomeReviews	Gene locus abkC in contig CM000150_GR.
KEGG	ddi:DDB_0220789.
Organism-specific databases
dictyBase	DDB_G0267774. abkC.
Phylogenomic databases
HOGENOM	HBG621148.
InParanoid	Q55G83.
OMA	LRFRYPG.
Family and domain databases
InterPro	IPR004147. ABC_1. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABKC_DICDI

Accession

Primary (citable) accession number: Q55G83

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 24, 2005
Last modified:	December 15, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)