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Reviewed, UniProtKB/Swiss-Prot Q55G11 (NCSEB_DICDI)

Last modified November 3, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Neutral ceramidase B
      Short name=N-CDase B
      Short name=NCDase B
    EC=3.5.1.23
Alternative name(s):
    Acylsphingosine deacylase 2B
    N-acylsphingosine amidohydrolase 2B
Gene names
Name: dcd2B
ORF Names: DDB_G0268374
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length718 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid By similarity.

Catalytic activity

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the neutral ceramidase family.

Ontologies

Keywords
   Biological processLipid metabolism
Sphingolipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processsphingolipid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionceramidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 718698Neutral ceramidase B
PRO_0000247109

Sites

Active site2981Nucleophile By similarity

Amino acid modifications

Glycosylation2241N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation3581N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation4221N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Potential
Glycosylation6101N-linked (GlcNAc...) Potential
Glycosylation6141N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q55G11-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: BDAE0B6C79271AFA

FASTA71878,609
        10         20         30         40         50         60 
MINSFKKLII LISLVIILLS SNNIFIDSFK IPVNQKNVKS SGDSSYQIGA GIYDITGASA 

        70         80         90        100        110        120 
EVNLMGYANP LQVGAGIHFR QRARAFVFVD SNGNRAVYVS TDSCMIFQEV KIHVVELLQD 

       130        140        150        160        170        180 
IFGPNVYTEA NVLLSGTHTH SGPAGFSQYA LYGITSLGFY KKNFDTICNG IVQAIVKAHK 

       190        200        210        220        230        240 
SVQPANMFTE TGELWNTNIN RSPFAYDNNP EEEKAMYDSN VDKNMTVLRI EDMNGNPFAA 

       250        260        270        280        290        300 
ISFFAVHCTS MNNTNHLISG DNKGYASYLW EKQVNGPGTA GKGPFVAAFG QSNEGDVSPN 

       310        320        330        340        350        360 
TRGPTCRDGS PCDYKTSTCN GRNEECWSLG PGKDGDMFES TQIIGGNQFN KALELFNNAS 

       370        380        390        400        410        420 
IQVSGPVQYR HSWVQFTNVS VEPPYNSGVD NATTCRGAMG YSFAAGTTDG PGAFNFVQSD 

       430        440        450        460        470        480 
NNTSGNPFWN FIGDFIAKPT PDQIRCQSPK PILLDVGMVE PIPWVPDVMP IQIVTIGQIV 

       490        500        510        520        530        540 
LVAVPGEFTT MSGRRLRNSV REIIGESIEN PIVLIAGLSN TYSGYIATFE EYQVQRYEGA 

       550        560        570        580        590        600 
STVFGPHTLG SYMQEFGKLA QSIVDGTTVP AGPTPRNLTG HTLFFLPPVI VDAAPDFDDF 

       610        620        630        640        650        660 
GEVSIDVNLN YSVNETVSCV FYGGNPRNDF MIESSFLSVD LLTGTDQWTT VLDDGDWDTK 

       670        680        690        700        710 
FKWKMHDLGF SLITIEWVIA PDTTPGTYRI THSGFAKKNP FSSNLTPYQG ISRNFVVQ 

« Hide

Cross-references

Sequence databases

AAFI02000003 Genomic DNA. Translation: EAL73640.1.
RefSeqXP_647372.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3398682.
GenomeReviewsGene locus dcd2B in contig CM000150_GR.
KEGGddi:DDB_0232168.

Organism-specific databases

dictyBaseDDB_G0268374. dcd2B.

Phylogenomic databases

OMASWFAVHP.

Enzyme and pathway databases

BRENDA3.5.1.23. 424.

Family and domain databases

InterProIPR006823. Ceramidase_alk.
[Graphical view]
PANTHERPTHR12670. Ceramidase_alk. 1 hit.
PfamPF04734. Ceramidase_alk. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNCSEB_DICDI
AccessionPrimary (citable) accession number: Q55G11
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 24, 2005
Last modified: November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents