Q55G11 (NCSEB_DICDI) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 40.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Neutral ceramidase B Short name=N-CDase B Short name=NCDase B EC=3.5.1.23 Alternative name(s): Acylsphingosine deacylase 2B N-acylsphingosine amidohydrolase 2B | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 718 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid By similarity. |
| Catalytic activity | N-acylsphingosine + H2O = a carboxylate + sphingosine. |
| Subcellular location | Secreted Potential. |
| Sequence similarities | Belongs to the neutral ceramidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid metabolism Sphingolipid metabolism |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | ceramide metabolic process Inferred by curator. Source: dictyBase |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ceramidase activity Inferred from sequence or structural similarity. Source: dictyBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||
| Chain | 21 – 718 | 698 | Neutral ceramidase B | PRO_0000247109 | |||||
Sites | |||||||||
| Active site | 298 | 1 | Nucleophile By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 224 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 252 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 358 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 378 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 391 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 421 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 422 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 577 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 610 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 614 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000003 Genomic DNA. Translation: EAL73640.1. |
| RefSeq | XP_647372.1. XM_642280.1. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblProtists | DDB0232168; DDB0232168; DDB_G0268374. |
| GeneID | 8616181. |
| GenomeReviews | Gene locus dcd2B in contig CM000150_GR. |
| KEGG | ddi:DDB_G0268374. |
Organism-specific databases | |
| dictyBase | DDB_G0268374. dcd2B. |
Phylogenomic databases | |
| eggNOG | KOG2232. |
| GeneTree | EPrGT00050000005921. |
| HOGENOM | HBG315824. |
| OMA | SWFAVHP. |
| PhylomeDB | Q55G11. |
| ProtClustDB | PTZ00487. |
Family and domain databases | |
| InterPro | IPR006823. Ceramidase_alk. [Graphical view] |
| PANTHER | PTHR12670. Ceramidase_alk. 1 hit. |
| Pfam | PF04734. Ceramidase_alk. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NCSEB_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q55G11 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with