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Q55G10

- PNCB_DICDI

UniProt

Q55G10 - PNCB_DICDI

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Protein

Nicotinate phosphoribosyltransferase

Gene

naprt

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:naprt
ORF Names:DDB_G0268472
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268472. naprt.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Nicotinate phosphoribosyltransferasePRO_0000371328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0215395.

Structurei

3D structure databases

ProteinModelPortaliQ55G10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiCOG1488.
InParanoidiQ55G10.
KOiK00763.
OMAiNDLGYHA.
PhylomeDBiQ55G10.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55G10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQSNTPLKR KKTENGYSEN GSTTGATSNQ IRELKRATTV DYVYRDQESK
60 70 80 90 100
DKIKPLNGFV TPLLTDLYQI TMAYSLWKNN RHEIPAVFDL YFRKSPFGGE
110 120 130 140 150
FTVFAGLEEV IRFVSDFHYT KEEVGFIKEM IPDCEQEFLD YLSKLDSSSV
160 170 180 190 200
TLYAMKEGSV VFPRVPLLRV EGPMILCQLF ETTLLCLVNF ASLVATNAAR
210 220 230 240 250
HRLAVGKEKV MLEFGLRRAQ GPDGAMSASR YSYLGGADGT SNVLAHCFFG
260 270 280 290 300
IPIRGTHAHS FITNYSGPDE LLDASIKDTN GNVHNLLEMS QKYRDELGYT
310 320 330 340 350
ATNLSELVAF VAYARTFPNG LVALVDTYDT LASGVPNFIC VALALHQLGY
360 370 380 390 400
KAVGIRLDSG DLSYLSKASR KLFKQIGEQF KIDYFEKFSI VASNDLNEPT
410 420 430 440 450
IIALNRQGHE IDVFAIGTNL VTCQAQPALG CVYKLVEING SPRIKLSQEA
460 470 480 490 500
NKITLPGRKT AYRLFGSEGH PLVDLLVDDN DMIKDGSKQI PQVGKKVLCL
510 520 530 540 550
HPFEEQKRVI VTPVQIEKLH HIVFEKGQLT MPLPALNDIR EYCFQQISKV
560 570 580
REDHLRNSNP TPYKVSVTKE LFDTLHNLWL DSVPIKEMK
Length:589
Mass (Da):66,085
Last modified:May 24, 2005 - v1
Checksum:iD74F67EFBDE070C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 4871S → F in AAP69616. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214338 mRNA. Translation: AAP69616.1.
AAFI02000003 Genomic DNA. Translation: EAL73689.1.
RefSeqiXP_647373.1. XM_642281.1.

Genome annotation databases

EnsemblProtistsiDDB0215395; DDB0215395; DDB_G0268472.
GeneIDi8616182.
KEGGiddi:DDB_G0268472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214338 mRNA. Translation: AAP69616.1 .
AAFI02000003 Genomic DNA. Translation: EAL73689.1 .
RefSeqi XP_647373.1. XM_642281.1.

3D structure databases

ProteinModelPortali Q55G10.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0215395.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0215395 ; DDB0215395 ; DDB_G0268472 .
GeneIDi 8616182.
KEGGi ddi:DDB_G0268472.

Organism-specific databases

dictyBasei DDB_G0268472. naprt.

Phylogenomic databases

eggNOGi COG1488.
InParanoidi Q55G10.
KOi K00763.
OMAi NDLGYHA.
PhylomeDBi Q55G10.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

PROi Q55G10.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
    Huang C.-H., Peng J., Chen Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPNCB_DICDI
AccessioniPrimary (citable) accession number: Q55G10
Secondary accession number(s): Q6XQM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3