Q55G10 (PNCB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	naprt
ORF Names:	DDB_G0268472

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	589 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway nicotinate nucleotide salvage Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 589	589	Nicotinate phosphoribosyltransferase		PRO_0000371328
Experimental info
	Sequence conflict	487	1	S → F in AAP69616. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q55G10 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: D74F67EFBDE070C2	FASTA	589	66,085
	10 20 30 40 50 60 MSQSNTPLKR KKTENGYSEN GSTTGATSNQ IRELKRATTV DYVYRDQESK DKIKPLNGFV 70 80 90 100 110 120 TPLLTDLYQI TMAYSLWKNN RHEIPAVFDL YFRKSPFGGE FTVFAGLEEV IRFVSDFHYT 130 140 150 160 170 180 KEEVGFIKEM IPDCEQEFLD YLSKLDSSSV TLYAMKEGSV VFPRVPLLRV EGPMILCQLF 190 200 210 220 230 240 ETTLLCLVNF ASLVATNAAR HRLAVGKEKV MLEFGLRRAQ GPDGAMSASR YSYLGGADGT 250 260 270 280 290 300 SNVLAHCFFG IPIRGTHAHS FITNYSGPDE LLDASIKDTN GNVHNLLEMS QKYRDELGYT 310 320 330 340 350 360 ATNLSELVAF VAYARTFPNG LVALVDTYDT LASGVPNFIC VALALHQLGY KAVGIRLDSG 370 380 390 400 410 420 DLSYLSKASR KLFKQIGEQF KIDYFEKFSI VASNDLNEPT IIALNRQGHE IDVFAIGTNL 430 440 450 460 470 480 VTCQAQPALG CVYKLVEING SPRIKLSQEA NKITLPGRKT AYRLFGSEGH PLVDLLVDDN 490 500 510 520 530 540 DMIKDGSKQI PQVGKKVLCL HPFEEQKRVI VTPVQIEKLH HIVFEKGQLT MPLPALNDIR 550 560 570 580 EYCFQQISKV REDHLRNSNP TPYKVSVTKE LFDTLHNLWL DSVPIKEMK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltranferase family." Huang C.-H., Peng J., Chen Y. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY214338 mRNA. Translation: AAP69616.1. AAFI02000003 Genomic DNA. Translation: EAL73689.1.
RefSeq	XP_647373.1. XM_642281.1.
3D structure databases
HSSP	HSSP built from PDB template 2F7F based on UniProtKB Q830Y8.
ProteinModelPortal	Q55G10.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0215395.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0215395; DDB0215395; DDB_G0268472.
GeneID	8616182.
KEGG	ddi:DDB_G0268472.
Organism-specific databases
dictyBase	DDB_G0268472. naprt.
Phylogenomic databases
eggNOG	COG1488.
InParanoid	Q55G10.
KO	K00763.
OMA	FWPEYLR.
ProtClustDB	CLSZ2431533.
Enzyme and pathway databases
UniPathway	UPA00253; UER00457.
Family and domain databases
InterPro	IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR006405. Nic_PRibTrfase_put. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01513. NAPRTase_put. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_DICDI

Accession

Primary (citable) accession number: Q55G10
Secondary accession number(s): Q6XQM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)