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Q55G10

- PNCB_DICDI

UniProt

Q55G10 - PNCB_DICDI

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Protein
Nicotinate phosphoribosyltransferase
Gene
naprt, DDB_G0268472
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiREACT_215842. Nicotinamide salvaging.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:naprt
ORF Names:DDB_G0268472
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268472. naprt.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Nicotinate phosphoribosyltransferase
PRO_0000371328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0215395.

Structurei

3D structure databases

ProteinModelPortaliQ55G10.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
InParanoidiQ55G10.
KOiK00763.
OMAiNDLGYHA.
PhylomeDBiQ55G10.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55G10-1 [UniParc]FASTAAdd to Basket

« Hide

MSQSNTPLKR KKTENGYSEN GSTTGATSNQ IRELKRATTV DYVYRDQESK    50
DKIKPLNGFV TPLLTDLYQI TMAYSLWKNN RHEIPAVFDL YFRKSPFGGE 100
FTVFAGLEEV IRFVSDFHYT KEEVGFIKEM IPDCEQEFLD YLSKLDSSSV 150
TLYAMKEGSV VFPRVPLLRV EGPMILCQLF ETTLLCLVNF ASLVATNAAR 200
HRLAVGKEKV MLEFGLRRAQ GPDGAMSASR YSYLGGADGT SNVLAHCFFG 250
IPIRGTHAHS FITNYSGPDE LLDASIKDTN GNVHNLLEMS QKYRDELGYT 300
ATNLSELVAF VAYARTFPNG LVALVDTYDT LASGVPNFIC VALALHQLGY 350
KAVGIRLDSG DLSYLSKASR KLFKQIGEQF KIDYFEKFSI VASNDLNEPT 400
IIALNRQGHE IDVFAIGTNL VTCQAQPALG CVYKLVEING SPRIKLSQEA 450
NKITLPGRKT AYRLFGSEGH PLVDLLVDDN DMIKDGSKQI PQVGKKVLCL 500
HPFEEQKRVI VTPVQIEKLH HIVFEKGQLT MPLPALNDIR EYCFQQISKV 550
REDHLRNSNP TPYKVSVTKE LFDTLHNLWL DSVPIKEMK 589
Length:589
Mass (Da):66,085
Last modified:May 24, 2005 - v1
Checksum:iD74F67EFBDE070C2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 4871S → F in AAP69616. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY214338 mRNA. Translation: AAP69616.1.
AAFI02000003 Genomic DNA. Translation: EAL73689.1.
RefSeqiXP_647373.1. XM_642281.1.

Genome annotation databases

EnsemblProtistsiDDB0215395; DDB0215395; DDB_G0268472.
GeneIDi8616182.
KEGGiddi:DDB_G0268472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY214338 mRNA. Translation: AAP69616.1 .
AAFI02000003 Genomic DNA. Translation: EAL73689.1 .
RefSeqi XP_647373.1. XM_642281.1.

3D structure databases

ProteinModelPortali Q55G10.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0215395.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0215395 ; DDB0215395 ; DDB_G0268472 .
GeneIDi 8616182.
KEGGi ddi:DDB_G0268472.

Organism-specific databases

dictyBasei DDB_G0268472. naprt.

Phylogenomic databases

eggNOGi COG1488.
InParanoidi Q55G10.
KOi K00763.
OMAi NDLGYHA.
PhylomeDBi Q55G10.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
Reactomei REACT_215842. Nicotinamide salvaging.

Miscellaneous databases

PROi Q55G10.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
    Huang C.-H., Peng J., Chen Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPNCB_DICDI
AccessioniPrimary (citable) accession number: Q55G10
Secondary accession number(s): Q6XQM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi