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Q55G10 (PNCB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:naprt
ORF Names:DDB_G0268472
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Nicotinate phosphoribosyltransferase
PRO_0000371328

Experimental info

Sequence conflict4871S → F in AAP69616. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q55G10 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: D74F67EFBDE070C2

FASTA58966,085
        10         20         30         40         50         60 
MSQSNTPLKR KKTENGYSEN GSTTGATSNQ IRELKRATTV DYVYRDQESK DKIKPLNGFV 

        70         80         90        100        110        120 
TPLLTDLYQI TMAYSLWKNN RHEIPAVFDL YFRKSPFGGE FTVFAGLEEV IRFVSDFHYT 

       130        140        150        160        170        180 
KEEVGFIKEM IPDCEQEFLD YLSKLDSSSV TLYAMKEGSV VFPRVPLLRV EGPMILCQLF 

       190        200        210        220        230        240 
ETTLLCLVNF ASLVATNAAR HRLAVGKEKV MLEFGLRRAQ GPDGAMSASR YSYLGGADGT 

       250        260        270        280        290        300 
SNVLAHCFFG IPIRGTHAHS FITNYSGPDE LLDASIKDTN GNVHNLLEMS QKYRDELGYT 

       310        320        330        340        350        360 
ATNLSELVAF VAYARTFPNG LVALVDTYDT LASGVPNFIC VALALHQLGY KAVGIRLDSG 

       370        380        390        400        410        420 
DLSYLSKASR KLFKQIGEQF KIDYFEKFSI VASNDLNEPT IIALNRQGHE IDVFAIGTNL 

       430        440        450        460        470        480 
VTCQAQPALG CVYKLVEING SPRIKLSQEA NKITLPGRKT AYRLFGSEGH PLVDLLVDDN 

       490        500        510        520        530        540 
DMIKDGSKQI PQVGKKVLCL HPFEEQKRVI VTPVQIEKLH HIVFEKGQLT MPLPALNDIR 

       550        560        570        580 
EYCFQQISKV REDHLRNSNP TPYKVSVTKE LFDTLHNLWL DSVPIKEMK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
Huang C.-H., Peng J., Chen Y.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY214338 mRNA. Translation: AAP69616.1.
AAFI02000003 Genomic DNA. Translation: EAL73689.1.

3D structure databases

ProteinModelPortalQ55G10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0215395.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0215395; DDB0215395; DDB_G0268472.
KEGGddi:DDB_G0268472.

Organism-specific databases

dictyBaseDDB_G0268472. naprt.

Phylogenomic databases

eggNOGCOG1488.
InParanoidQ55G10.
KOK00763.
OMAFWPEYLR.
PhylomeDBQ55G10.
ProtClustDBCLSZ2431533.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Family and domain databases

InterProIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01513. NAPRTase_put. 1 hit.
ProtoNetSearch...

Other

PROQ55G10.

Entry information

Entry namePNCB_DICDI
AccessionPrimary (citable) accession number: Q55G10
Secondary accession number(s): Q6XQM3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase