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Protein

Nicotinate phosphoribosyltransferase

Gene

naprt

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathway:iNAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (naprt)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiREACT_284084. Nicotinamide salvaging.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:naprt
ORF Names:DDB_G0268472
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268472. naprt.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Nicotinate phosphoribosyltransferasePRO_0000371328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0215395.

Structurei

3D structure databases

ProteinModelPortaliQ55G10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiCOG1488.
InParanoidiQ55G10.
KOiK00763.
OMAiFWPEYLR.
PhylomeDBiQ55G10.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55G10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSNTPLKR KKTENGYSEN GSTTGATSNQ IRELKRATTV DYVYRDQESK
60 70 80 90 100
DKIKPLNGFV TPLLTDLYQI TMAYSLWKNN RHEIPAVFDL YFRKSPFGGE
110 120 130 140 150
FTVFAGLEEV IRFVSDFHYT KEEVGFIKEM IPDCEQEFLD YLSKLDSSSV
160 170 180 190 200
TLYAMKEGSV VFPRVPLLRV EGPMILCQLF ETTLLCLVNF ASLVATNAAR
210 220 230 240 250
HRLAVGKEKV MLEFGLRRAQ GPDGAMSASR YSYLGGADGT SNVLAHCFFG
260 270 280 290 300
IPIRGTHAHS FITNYSGPDE LLDASIKDTN GNVHNLLEMS QKYRDELGYT
310 320 330 340 350
ATNLSELVAF VAYARTFPNG LVALVDTYDT LASGVPNFIC VALALHQLGY
360 370 380 390 400
KAVGIRLDSG DLSYLSKASR KLFKQIGEQF KIDYFEKFSI VASNDLNEPT
410 420 430 440 450
IIALNRQGHE IDVFAIGTNL VTCQAQPALG CVYKLVEING SPRIKLSQEA
460 470 480 490 500
NKITLPGRKT AYRLFGSEGH PLVDLLVDDN DMIKDGSKQI PQVGKKVLCL
510 520 530 540 550
HPFEEQKRVI VTPVQIEKLH HIVFEKGQLT MPLPALNDIR EYCFQQISKV
560 570 580
REDHLRNSNP TPYKVSVTKE LFDTLHNLWL DSVPIKEMK
Length:589
Mass (Da):66,085
Last modified:May 24, 2005 - v1
Checksum:iD74F67EFBDE070C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 4871S → F in AAP69616 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214338 mRNA. Translation: AAP69616.1.
AAFI02000003 Genomic DNA. Translation: EAL73689.1.
RefSeqiXP_647373.1. XM_642281.1.

Genome annotation databases

EnsemblProtistsiDDB0215395; DDB0215395; DDB_G0268472.
GeneIDi8616182.
KEGGiddi:DDB_G0268472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214338 mRNA. Translation: AAP69616.1.
AAFI02000003 Genomic DNA. Translation: EAL73689.1.
RefSeqiXP_647373.1. XM_642281.1.

3D structure databases

ProteinModelPortaliQ55G10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0215395; DDB0215395; DDB_G0268472.
GeneIDi8616182.
KEGGiddi:DDB_G0268472.

Organism-specific databases

dictyBaseiDDB_G0268472. naprt.

Phylogenomic databases

eggNOGiCOG1488.
InParanoidiQ55G10.
KOiK00763.
OMAiFWPEYLR.
PhylomeDBiQ55G10.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
ReactomeiREACT_284084. Nicotinamide salvaging.

Miscellaneous databases

PROiQ55G10.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
    Huang C.-H., Peng J., Chen Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPNCB_DICDI
AccessioniPrimary (citable) accession number: Q55G10
Secondary accession number(s): Q6XQM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.