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Q55G10

- PNCB_DICDI

UniProt

Q55G10 - PNCB_DICDI

Protein

Nicotinate phosphoribosyltransferase

Gene

naprt

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide salvage Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_215842. Nicotinamide salvaging.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Gene namesi
    Name:naprt
    ORF Names:DDB_G0268472
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0268472. naprt.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589Nicotinate phosphoribosyltransferasePRO_0000371328Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0215395.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55G10.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    InParanoidiQ55G10.
    KOiK00763.
    OMAiNDLGYHA.
    PhylomeDBiQ55G10.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55G10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSNTPLKR KKTENGYSEN GSTTGATSNQ IRELKRATTV DYVYRDQESK    50
    DKIKPLNGFV TPLLTDLYQI TMAYSLWKNN RHEIPAVFDL YFRKSPFGGE 100
    FTVFAGLEEV IRFVSDFHYT KEEVGFIKEM IPDCEQEFLD YLSKLDSSSV 150
    TLYAMKEGSV VFPRVPLLRV EGPMILCQLF ETTLLCLVNF ASLVATNAAR 200
    HRLAVGKEKV MLEFGLRRAQ GPDGAMSASR YSYLGGADGT SNVLAHCFFG 250
    IPIRGTHAHS FITNYSGPDE LLDASIKDTN GNVHNLLEMS QKYRDELGYT 300
    ATNLSELVAF VAYARTFPNG LVALVDTYDT LASGVPNFIC VALALHQLGY 350
    KAVGIRLDSG DLSYLSKASR KLFKQIGEQF KIDYFEKFSI VASNDLNEPT 400
    IIALNRQGHE IDVFAIGTNL VTCQAQPALG CVYKLVEING SPRIKLSQEA 450
    NKITLPGRKT AYRLFGSEGH PLVDLLVDDN DMIKDGSKQI PQVGKKVLCL 500
    HPFEEQKRVI VTPVQIEKLH HIVFEKGQLT MPLPALNDIR EYCFQQISKV 550
    REDHLRNSNP TPYKVSVTKE LFDTLHNLWL DSVPIKEMK 589
    Length:589
    Mass (Da):66,085
    Last modified:May 24, 2005 - v1
    Checksum:iD74F67EFBDE070C2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti487 – 4871S → F in AAP69616. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214338 mRNA. Translation: AAP69616.1.
    AAFI02000003 Genomic DNA. Translation: EAL73689.1.
    RefSeqiXP_647373.1. XM_642281.1.

    Genome annotation databases

    EnsemblProtistsiDDB0215395; DDB0215395; DDB_G0268472.
    GeneIDi8616182.
    KEGGiddi:DDB_G0268472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214338 mRNA. Translation: AAP69616.1 .
    AAFI02000003 Genomic DNA. Translation: EAL73689.1 .
    RefSeqi XP_647373.1. XM_642281.1.

    3D structure databases

    ProteinModelPortali Q55G10.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0215395.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0215395 ; DDB0215395 ; DDB_G0268472 .
    GeneIDi 8616182.
    KEGGi ddi:DDB_G0268472.

    Organism-specific databases

    dictyBasei DDB_G0268472. naprt.

    Phylogenomic databases

    eggNOGi COG1488.
    InParanoidi Q55G10.
    KOi K00763.
    OMAi NDLGYHA.
    PhylomeDBi Q55G10.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    Reactomei REACT_215842. Nicotinamide salvaging.

    Miscellaneous databases

    PROi Q55G10.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
      Huang C.-H., Peng J., Chen Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPNCB_DICDI
    AccessioniPrimary (citable) accession number: Q55G10
    Secondary accession number(s): Q6XQM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3