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Protein

Proteasome subunit alpha type-5

Gene

psmA5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DDI-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DDI-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DDI-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DDI-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DDI-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DDI-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DDI-5632684. Hedgehog 'on' state.
R-DDI-5658442. Regulation of RAS by GAPs.
R-DDI-5689603. UCH proteinases.
R-DDI-5689880. Ub-specific processing proteases.
R-DDI-6798695. Neutrophil degranulation.
R-DDI-68949. Orc1 removal from chromatin.
R-DDI-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DDI-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DDI-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DDI-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Gene namesi
Name:psmA5
ORF Names:DDB_G0268538
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268538. psmA5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284861 – 241Proteasome subunit alpha type-5Add BLAST241

Proteomic databases

PaxDbiQ55G04.
PRIDEiQ55G04.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232930.

Structurei

3D structure databases

ProteinModelPortaliQ55G04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0176. Eukaryota.
COG0638. LUCA.
InParanoidiQ55G04.
KOiK02729.
OMAiEPGKTFH.
PhylomeDBiQ55G04.

Family and domain databases

CDDicd03753. proteasome_alpha_type_5. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR033812. Proteasome_alpha_type_5.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55G04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTRSEYDR GVNTFSPEGR LFQVEYALEA IKLGIGVQCE EGVVLAVEKR
60 70 80 90 100
LTSPLLEPSS IQKVVEIDYH LICALSGLVA DARTIIDHAR IETQNHRFNY
110 120 130 140 150
NEPMGVESCV QSICDLALRF GENRNSGEER MSRPFGVALL IAGIDEKGPS
160 170 180 190 200
LYYSDPSGTF TQFHAKAIGA GSEGAQTTLQ EKYSKTLTIA ECQKLALTTL
210 220 230 240
KQVMEEAITT TNVELAVITK ADQKFKIYNK EELATVIQTL E
Length:241
Mass (Da):26,687
Last modified:May 24, 2005 - v1
Checksum:iD3AF4370BE0D0D7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73722.1.
RefSeqiXP_647379.1. XM_642287.1.

Genome annotation databases

EnsemblProtistsiEAL73722; EAL73722; DDB_G0268538.
GeneIDi8616188.
KEGGiddi:DDB_G0268538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73722.1.
RefSeqiXP_647379.1. XM_642287.1.

3D structure databases

ProteinModelPortaliQ55G04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232930.

Protein family/group databases

MEROPSiT01.975.

Proteomic databases

PaxDbiQ55G04.
PRIDEiQ55G04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL73722; EAL73722; DDB_G0268538.
GeneIDi8616188.
KEGGiddi:DDB_G0268538.

Organism-specific databases

dictyBaseiDDB_G0268538. psmA5.

Phylogenomic databases

eggNOGiKOG0176. Eukaryota.
COG0638. LUCA.
InParanoidiQ55G04.
KOiK02729.
OMAiEPGKTFH.
PhylomeDBiQ55G04.

Enzyme and pathway databases

ReactomeiR-DDI-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DDI-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DDI-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DDI-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DDI-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DDI-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DDI-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DDI-5632684. Hedgehog 'on' state.
R-DDI-5658442. Regulation of RAS by GAPs.
R-DDI-5689603. UCH proteinases.
R-DDI-5689880. Ub-specific processing proteases.
R-DDI-6798695. Neutrophil degranulation.
R-DDI-68949. Orc1 removal from chromatin.
R-DDI-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DDI-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DDI-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DDI-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ55G04.

Family and domain databases

CDDicd03753. proteasome_alpha_type_5. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR033812. Proteasome_alpha_type_5.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSA5_DICDI
AccessioniPrimary (citable) accession number: Q55G04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.