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Protein

Proteasome subunit alpha type-5

Gene

psmA5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-6798695 Neutrophil degranulation
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.975

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Gene namesi
Name:psmA5
ORF Names:DDB_G0268538
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268538 psmA5

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex, alpha-subunit complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284861 – 241Proteasome subunit alpha type-5Add BLAST241

Proteomic databases

PaxDbiQ55G04
PRIDEiQ55G04

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232930

Structurei

3D structure databases

ProteinModelPortaliQ55G04
SMRiQ55G04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0176 Eukaryota
COG0638 LUCA
InParanoidiQ55G04
KOiK02729
OMAiFQVEYAR
PhylomeDBiQ55G04

Family and domain databases

CDDicd03753 proteasome_alpha_type_5, 1 hit
Gene3Di3.60.20.101 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR033812 Proteasome_alpha_type_5
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q55G04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTRSEYDR GVNTFSPEGR LFQVEYALEA IKLGIGVQCE EGVVLAVEKR
60 70 80 90 100
LTSPLLEPSS IQKVVEIDYH LICALSGLVA DARTIIDHAR IETQNHRFNY
110 120 130 140 150
NEPMGVESCV QSICDLALRF GENRNSGEER MSRPFGVALL IAGIDEKGPS
160 170 180 190 200
LYYSDPSGTF TQFHAKAIGA GSEGAQTTLQ EKYSKTLTIA ECQKLALTTL
210 220 230 240
KQVMEEAITT TNVELAVITK ADQKFKIYNK EELATVIQTL E
Length:241
Mass (Da):26,687
Last modified:May 24, 2005 - v1
Checksum:iD3AF4370BE0D0D7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA Translation: EAL73722.1
RefSeqiXP_647379.1, XM_642287.1

Genome annotation databases

EnsemblProtistsiEAL73722; EAL73722; DDB_G0268538
GeneIDi8616188
KEGGiddi:DDB_G0268538

Similar proteinsi

Entry informationi

Entry nameiPSA5_DICDI
AccessioniPrimary (citable) accession number: Q55G04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome