Reviewed, UniProtKB/Swiss-Prot Q55FT9 (ABIA_DICDI)

Names and origin

Protein names

Recommended name:
    Abl interactor homolog

Gene names

Name:	abiA
ORF Names:	DDB_G0267956

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in regulation of actin and microtubule organization. Required for proper cytokinesis. Ref.2 Ref.3
Subunit structure	Part of a Scar/WAVE complex containing brk1, scrA, abiA, pirA and napA. Interacts with scrA. Ref.2
Disruption phenotype	Cells show no developmental defects, mild motility defects and serious defects in cytokinesis. Ref.3
Sequence similarities	Belongs to the ABI family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW chemotaxis to folate Ref.3 Inferred from mutant phenotype. Source: dictyBase cytokinesis Ref.3 Inferred from mutant phenotype. Source: dictyBase establishment of protein localization Ref.3 Inferred from mutant phenotype. Source: dictyBase regulation of actin polymerization or depolymerization Traceable author statement. Source: dictyBase
Cellular component	SCAR complex Ref.2 Ref.3 Inferred from physical interaction. Source: dictyBase
Molecular function	protein binding Ref.2 Ref.3 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
pirA	Q6UK63	1	EBI-1808197,EBI-1808286
scrA	Q54NF8	2	EBI-1808197,EBI-1808146

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Abl interactor homolog		PRO_0000331387
Regions
	Coiled coil	73 – 104	32	Potential
	Compositional bias	166 – 205	40	Ser-rich
	Compositional bias	208 – 331	124	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q55FT9-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 0EBD2BE771A2D7DD	FASTA	332	35,313
	10 20 30 40 50 60 MSESIDINVY SQTTIPNAMA ELMDNHNKME QISAYCKSLY ANGDAAQAYE QTQGYAKNAL 70 80 90 100 110 120 LNVAYHIQTV GTHITSLLQL QTNEMEKLNI EIQTLTQRVR MIHDSTGTNV FSNQDAAKPY 130 140 150 160 170 180 KSSLKNRKVD TEATKAPVKY VHKPISYGIS ASDINQNGVP PPLNHSNSSA NLTSSSGHLA 190 200 210 220 230 240 ASSTSNSSTP SYQSPSYSSQ PTISSGTPPP IQKQPPRVGN APPPPSLSVP AAPPPPVMNV 250 260 270 280 290 300 PPPPPTSQRP SSVNNNAPSN DFPPPPPPSS SSSGGDLPPP PSFGLPPPPT LGDDFPPPPP 310 320 330 PPVGSYDFPP PPARPQSQFY DHNDFPPPPP PM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The N-terminus of Dictyostelium Scar interacts with Abi and HSPC300 and is essential for proper regulation and function." Caracino D., Jones C., Compton M., Saxe C.L. III Mol. Biol. Cell 18:1609-1620(2007) [PubMed: 17314411] [Abstract] Cited for: IDENTIFICATION IN THE WAVE COMPLEX, INTERACTION WITH SCRA, FUNCTION.
[3]	"Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE complex in cytokinesis." Pollitt A.Y., Insall R.H. Curr. Biol. 18:203-210(2008) [PubMed: 18261908] [Abstract] Cited for: IDENTIFICATION IN THE WAVE COMPLEX, DISRUPTION PHENOTYPE, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000003 Genomic DNA. Translation: EAL73431.1.
RefSeq	XP_647444.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55FT9. 2 interactions.
Genome annotation databases
GeneID	3398473.
GenomeReviews	Gene locus abiA in contig CM000150_GR.
KEGG	ddi:DDB_0231426.
Organism-specific databases
dictyBase	DDB_G0267956. abiA.
Phylogenomic databases
OMA	PPPGNMG.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ABIA_DICDI

Accession

Primary (citable) accession number: Q55FT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	December 15, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)