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Q55FT1 (DPYD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydropyrimidine dehydrogenase [NADP+]

Short name=DHPDHase
Short name=DPD
EC=1.3.1.2
Alternative name(s):
Dihydrothymine dehydrogenase
Dihydrouracil dehydrogenase
Gene names
Name:pyd1
ORF Names:DDB_G0267966
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1009 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine By similarity.

Catalytic activity

5,6-dihydrouracil + NADP+ = uracil + NADPH.

Cofactor

Binds 2 4Fe-4S clusters By similarity.

FAD By similarity.

FMN By similarity.

Pathway

Amino-acid biosynthesis; beta-alanine biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the dihydropyrimidine dehydrogenase family.

Contains 3 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10091009Dihydropyrimidine dehydrogenase [NADP+]
PRO_0000327500

Regions

Domain69 – 99314Fe-4S ferredoxin-type 1
Domain932 – 964334Fe-4S ferredoxin-type 2
Domain965 – 995314Fe-4S ferredoxin-type 3
Nucleotide binding334 – 35017NADP Potential
Nucleotide binding468 – 47912FAD Potential
Region659 – 67618Uracil binding Potential

Sites

Metal binding9411Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9441Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9471Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9511Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9741Iron-sulfur 2 (4Fe-4S) Potential
Metal binding9771Iron-sulfur 2 (4Fe-4S) Potential
Metal binding9801Iron-sulfur 2 (4Fe-4S) Potential
Metal binding9841Iron-sulfur 2 (4Fe-4S) Potential

Experimental info

Sequence conflict681E → G in AAQ11981. Ref.1
Sequence conflict2341R → H in AAQ11981. Ref.1
Sequence conflict5321S → C in AAQ11981. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q55FT1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: CBC49049106B86B7

FASTA1,009110,444
        10         20         30         40         50         60 
MTGHTGDVSQ VHDIEILALN PTVNKHATFK PTIVSKKDKE NWARLDHCKK GCELKNDFED 

        70         80         90        100        110        120 
VKPTTLTERG ALFESARCLK CADAPCQKGC PTQLDIKSFI SSISTKNYYG AAKTIFSDNP 

       130        140        150        160        170        180 
LGLTCGMVCP VSSLCQYGCN LAATEEGPIN IGGLQQFATE VFKKMNIPQI RDPSLTPLSQ 

       190        200        210        220        230        240 
LPESYKAKIA LIGCGPTSIS CATFLGRLGY TDVTIFEKEQ YLGGLSSSEI PNYRLNYEVV 

       250        260        270        280        290        300 
EFEIKLMKDL GVKVEYGKRL GENGFTVESL QKQGYEAIYL GIGMPEPKID PVFNELTSDQ 

       310        320        330        340        350        360 
GFFSSKEFLP KVSKASKAGM CGCKSQLPQL NGRVIVLGAG DTAFDCATSA FRCGASRVTV 

       370        380        390        400        410        420 
CFRRGFSDMR AVPEEVDIAK DERCEFLPYV LPKQVIKRDG KVVAMEFYKT EKGDDGNYSV 

       430        440        450        460        470        480 
DEDQFFRVKC DYIISAFGSQ IGSVAESCSP LQFNKWGTAD IDPMTMTSKH AEWLFCGGDL 

       490        500        510        520        530        540 
VGNGTTVEAV NDGKTASWNI HKYLQSLHGI PIPDGPPQLP NFFTPIDLVD ISVEMCGMKF 

       550        560        570        580        590        600 
PNPFGLASAT PATSAAMIRR SFEQGWGFAV TKTFSLDKDL VTNVSPRIVR GTTSGHHFGP 

       610        620        630        640        650        660 
GQGAFLNIEL ISEKTCHYWC KAIGELKRDF PDRIVIASIM CGFNKEDWTQ LAKMAEASGA 

       670        680        690        700        710        720 
DGIELNLSCP HGMGEKGMGL ACGQDTELVF HICQWVRAAT RLPFFAKLTP NVTEIKEIAK 

       730        740        750        760        770        780 
AAHDGGADGV TAINTVSGLM GLKGDSNAWP AIGDEKRTTY GGVSGNATRP IALRAVSSIR 

       790        800        810        820        830        840 
KSLPDYPIMA TGGADSADAT IQFLHCGASV VQICSSVQNQ DFTVVQDYIT GLKTYLYMQS 

       850        860        870        880        890        900 
REDLLQWDGQ SPPNEIINKN PKLKGLPKFG KYLLERNRID TEEKQNIDLQ KVKNPLVPSP 

       910        920        930        940        950        960 
NPTHPVPSLK DQINRAIPRI GRHDDLKRDQ QVVALIDEDK CINCGKCYMT CNDSGYQAIK 

       970        980        990       1000 
FDGKTHIPLV TDLCTGCDLC LSVCPVPDCI TMVPRETIYV PDRGLTVQN 

« Hide

References

« Hide 'large scale' references
[1]"Dihydropyrimidine dehydrogenases and the evolution of the pyrimidine degradation pathway."
Gojkovic Z., Sandrini M.P.B., Piskur J.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF545064 mRNA. Translation: AAQ11981.1.
AAFI02000003 Genomic DNA. Translation: EAL73436.1.
RefSeqXP_647452.1. XM_642360.1.

3D structure databases

HSSPHSSP built from PDB template 1GTE based on UniProtKB Q28943.
ProteinModelPortalQ55FT1.
SMRQ55FT1. Positions 11-1005.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ55FT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231100; DDB0231100; DDB_G0267966.
GeneID8616259.
GenomeReviewsGene locus pyd1 in contig CM000150_GR.
KEGGddi:DDB_G0267966.

Organism-specific databases

dictyBaseDDB_G0267966. pyd1.

Phylogenomic databases

eggNOGKOG1799.
GeneTreeEPrGT00050000000861.
HOGENOMHBG314257.
OMAAYWCQSV.
PhylomeDBQ55FT1.
ProtClustDBCLSZ2431542.

Family and domain databases

InterProIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR012135. Dihydroorotate_DH_1_2.
IPR012285. Fum_reductase_C.
IPR009051. Helical_ferredxn.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
KOK00207.
PfamPF01180. DHO_dh. 1 hit.
PF12838. Fer4_7. 1 hit.
[Graphical view]
SUPFAMSSF46548. Helical_ferredxn. 1 hit.
TIGRFAMsTIGR01037. PyrD_sub1_fam. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPYD_DICDI
AccessionPrimary (citable) accession number: Q55FT1
Secondary accession number(s): Q5ZQQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families