Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q55FN7 (ODBB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
EC=1.2.4.4
Alternative name(s):
3-methyl-2-oxobutanoate dehydrogenase
Branched-chain alpha-keto acid dehydrogenase E1 component beta chain
Short name=BCKDE1B
Short name=BCKDH E1-beta
Gene names
Name:bkdB
ORF Names:DDB_G0268020
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.

Subunit structure

Heterodimer of an alpha and a beta chain By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2525Mitochondrion Potential
Chain26 – 3703452-oxoisovalerate dehydrogenase subunit beta, mitochondrial
PRO_0000327589

Sequences

Sequence LengthMass (Da)Tools
Q55FN7 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 083E690721B9559D

FASTA37040,725
        10         20         30         40         50         60 
MLRGNNIKKV NSLLVRSFHS TVGNRSGGPS TPINYPSLEI ENAGEKQKMN LFQAINNGMD 

        70         80         90        100        110        120 
IAMQKDSKAV VFGEDVGFGG VFRCTVGLRD KYGASRVFNT PLCEQGIAGF AIGLAAQGAT 

       130        140        150        160        170        180 
PIAEIQFADY IFPAFDQIVN EAAKYRYRSG GQFDCGSLTI RSPYGAVGHG GHYHSQSPES 

       190        200        210        220        230        240 
YFGHTPGLKV VIPSTPIEAK GLLLASIREK DPVIFFEPKL MYRSAVEEVP IGDYEIPLGK 

       250        260        270        280        290        300 
ARIVKEGKDI TIIGWGAQMR VLLQAVNMAE EKLGISCELI DLRTIQPWDV ETVVESVKKT 

       310        320        330        340        350        360 
GRVVISHEAP KTGGWAAEIS ATIQERCFLH LEAPIQRVCG YDTPFPLIFE KFYVPDHLKN 

       370 
FESIKKTMVY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFI02000003 Genomic DNA. Translation: EAL73463.1.
RefSeqXP_647496.1. XM_642404.1.

3D structure databases

HSSPHSSP built from PDB template 2BFF based on UniProtKB P21953.
ProteinModelPortalQ55FN7.
SMRQ55FN7. Positions 44-370.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ55FN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0230185; DDB0230185; DDB_G0268020.
GeneID8616303.
GenomeReviewsGene locus bkdB in contig CM000150_GR.
KEGGddi:DDB_G0268020.

Organism-specific databases

dictyBaseDDB_G0268020. bkdB.

Phylogenomic databases

eggNOGKOG0525.
GeneTreeEPrGT00050000005772.
HOGENOMHBG753264.
OMAKYXVVIP.
PhylomeDBQ55FN7.
ProtClustDBPTZ00182.

Family and domain databases

InterProIPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00167.
PfamPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODBB_DICDI
AccessionPrimary (citable) accession number: Q55FN7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents