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Protein

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

Gene

bkdB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

ReactomeiR-DDI-389661. Glyoxylate metabolism and glycine degradation.
R-DDI-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC:1.2.4.4)
Alternative name(s):
3-methyl-2-oxobutanoate dehydrogenase
Branched-chain alpha-keto acid dehydrogenase E1 component beta chain
Short name:
BCKDE1B
Short name:
BCKDH E1-beta
Gene namesi
Name:bkdB
ORF Names:DDB_G0268020
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268020. bkdB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence analysisAdd
BLAST
Chaini26 – 3703452-oxoisovalerate dehydrogenase subunit beta, mitochondrialPRO_0000327589Add
BLAST

Proteomic databases

PaxDbiQ55FN7.
PRIDEiQ55FN7.

Interactioni

Subunit structurei

Heterotetramer of 2 alpha and 2 beta chains.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230185.

Structurei

3D structure databases

ProteinModelPortaliQ55FN7.
SMRiQ55FN7. Positions 44-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0525. Eukaryota.
COG0022. LUCA.
InParanoidiQ55FN7.
KOiK00167.
OMAiLAWGAQM.
PhylomeDBiQ55FN7.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55FN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGNNIKKV NSLLVRSFHS TVGNRSGGPS TPINYPSLEI ENAGEKQKMN
60 70 80 90 100
LFQAINNGMD IAMQKDSKAV VFGEDVGFGG VFRCTVGLRD KYGASRVFNT
110 120 130 140 150
PLCEQGIAGF AIGLAAQGAT PIAEIQFADY IFPAFDQIVN EAAKYRYRSG
160 170 180 190 200
GQFDCGSLTI RSPYGAVGHG GHYHSQSPES YFGHTPGLKV VIPSTPIEAK
210 220 230 240 250
GLLLASIREK DPVIFFEPKL MYRSAVEEVP IGDYEIPLGK ARIVKEGKDI
260 270 280 290 300
TIIGWGAQMR VLLQAVNMAE EKLGISCELI DLRTIQPWDV ETVVESVKKT
310 320 330 340 350
GRVVISHEAP KTGGWAAEIS ATIQERCFLH LEAPIQRVCG YDTPFPLIFE
360 370
KFYVPDHLKN FESIKKTMVY
Length:370
Mass (Da):40,725
Last modified:May 24, 2005 - v1
Checksum:i083E690721B9559D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73463.1.
RefSeqiXP_647496.1. XM_642404.1.

Genome annotation databases

EnsemblProtistsiDDB0230185; DDB0230185; DDB_G0268020.
GeneIDi8616303.
KEGGiddi:DDB_G0268020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73463.1.
RefSeqiXP_647496.1. XM_642404.1.

3D structure databases

ProteinModelPortaliQ55FN7.
SMRiQ55FN7. Positions 44-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0230185.

Proteomic databases

PaxDbiQ55FN7.
PRIDEiQ55FN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0230185; DDB0230185; DDB_G0268020.
GeneIDi8616303.
KEGGiddi:DDB_G0268020.

Organism-specific databases

dictyBaseiDDB_G0268020. bkdB.

Phylogenomic databases

eggNOGiKOG0525. Eukaryota.
COG0022. LUCA.
InParanoidiQ55FN7.
KOiK00167.
OMAiLAWGAQM.
PhylomeDBiQ55FN7.

Enzyme and pathway databases

ReactomeiR-DDI-389661. Glyoxylate metabolism and glycine degradation.
R-DDI-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

PROiQ55FN7.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiODBB_DICDI
AccessioniPrimary (citable) accession number: Q55FN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.