Reviewed,
UniProtKB/Swiss-Prot Q55FN5 (HDA11_DICDI)
Last modified
February 9, 2010.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Type-1 histone deacetylase 1 Short name=DdHdaA EC=3.5.1.98 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 495 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. |
| Catalytic activity | Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Subcellular location | |
| Developmental stage | Expressed throughout growth and development. Ref.2 |
| Sequence similarities | Belongs to the histone deacetylase family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Cytoplasm Nucleus |
| Ligand | Metal-binding |
| Molecular function | Chromatin regulator Hydrolase Repressor |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | histone deacetylation Inferred from electronic annotation. Source: InterPro regulation of transcriptionInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | histone deacetylase activity Inferred from electronic annotation. Source: InterPro metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 495 | 495 | Type-1 histone deacetylase 1 | PRO_0000331369 | |||||
Regions | |||||||||
| Compositional bias | 294 – 297 | 4 | Poly-Gly | ||||||
| Compositional bias | 457 – 480 | 24 | Poly-Asn | ||||||
Sites | |||||||||
| Active site | 136 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 171 | 1 | Divalent metal cation By similarity | ||||||
| Metal binding | 173 | 1 | Divalent metal cation By similarity | ||||||
| Metal binding | 259 | 1 | Divalent metal cation By similarity | ||||||
| Binding site | 94 | 1 | Substrate By similarity | ||||||
| Binding site | 144 | 1 | Substrate; via carbonyl oxygen By similarity | ||||||
| Binding site | 298 | 1 | Substrate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [2] | "Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum." Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V. J. Mol. Biol. 391:833-848(2009) [PubMed: 19576222] [Abstract] Cited for: DEVELOPMENTAL STAGE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000003 Genomic DNA. Translation: EAL73465.1. |
| RefSeq | XP_647498.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1W22 based on UniProtKB Q9BY41. |
| SMR | Q55FN5. Positions 7-368. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q55FN5. |
Genome annotation databases | |
| GeneID | 8616305. |
| KEGG | ddi:DDB_0234190. |
Organism-specific databases | |
| dictyBase | DDB_G0268024. hdaA. |
Phylogenomic databases | |
| eggNOG | KOG1342. |
| HOGENOM | HBG396919. |
| OMA | IFKPVIS. |
| PhylomeDB | Q55FN5. |
Family and domain databases | |
| InterPro | IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view] |
| Gene3D | G3DSA:3.40.800.20. His_deacetylse. 1 hit. |
| PANTHER | PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit. |
| Pfam | PF00850. Hist_deacetyl. 1 hit. [Graphical view] |
| PIRSF | PIRSF037913. His_deacetylse_1. 1 hit. |
| PRINTS | PR01270. HDASUPER. PR01271. HISDACETLASE. |
| ProtoNet | Search... |
Entry information
| Entry name | HDA11_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q55FN5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


