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Protein

Type-1 histone deacetylase 1

Gene

hdaA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateBy similarity1
Active sitei136Proton acceptorBy similarity1
Binding sitei144Substrate; via carbonyl oxygenBy similarity1
Metal bindingi171Divalent metal cationBy similarity1
Metal bindingi173Divalent metal cationBy similarity1
Metal bindingi259Divalent metal cationBy similarity1
Binding sitei298SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-DDI-1538133 G0 and Early G1

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 histone deacetylase 1 (EC:3.5.1.98)
Short name:
DdHdaA
Gene namesi
Name:hdaA
ORF Names:DDB_G0268024
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268024 hdaA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313691 – 495Type-1 histone deacetylase 1Add BLAST495

Proteomic databases

PaxDbiQ55FN5

Expressioni

Developmental stagei

Expressed throughout growth and development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0234190

Structurei

3D structure databases

ProteinModelPortaliQ55FN5
SMRiQ55FN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi294 – 297Poly-Gly4
Compositional biasi457 – 480Poly-AsnAdd BLAST24

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
InParanoidiQ55FN5
KOiK06067
OMAiPRAWTHL
PhylomeDBiQ55FN5

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q55FN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRKVSYFY DNEVGNHYYG PNHPMKPHRM RMTHDLVLNY GIYKKMQIFR
60 70 80 90 100
PRKASELELT NFHSDDYINF LKLVTPDNMH DYSKQLVKFN VREDCPVFDG
110 120 130 140 150
MYNFCQISSG GSIGCAVKVN SKESDVAINW AGGLHHAKKS EASGFCYTND
160 170 180 190 200
IVLSILELLK HHERVLYIDI DIHHGDGVEE AFYTTDRVMT VSFHKYGDYF
210 220 230 240 250
PGTGDVKDIG ADKGKYYSLN FPLKDGIDDE SYQSIFRPII RSVMDFYRPG
260 270 280 290 300
AVVIQCGADS LTGDRLGCFN LTLRGHAQCI EFLKSFNVPL VVLGGGGYTI
310 320 330 340 350
KNVARCWTYE TSILVDSELK DELPYNDYLE YYGPEYRLHI TPNNMENQNT
360 370 380 390 400
KDYLEKLKIQ LLENLRNLNH APAAAHHDIP PDSFNYSDDE DDEDPDVRIS
410 420 430 440 450
EADRDKKVHH QGELSDSDEE DGRRNYSNGL EATSTSRRNQ VSISAYDKER
460 470 480 490
PSYNSRNNNN NNNNNNNNNN NNNNNSNNNN SHHHNEDADV DMDSG
Length:495
Mass (Da):56,633
Last modified:May 24, 2005 - v1
Checksum:iB325100AB480CD63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA Translation: EAL73465.1
RefSeqiXP_647498.1, XM_642406.1

Genome annotation databases

EnsemblProtistsiEAL73465; EAL73465; DDB_G0268024
GeneIDi8616305
KEGGiddi:DDB_G0268024

Similar proteinsi

Entry informationi

Entry nameiHDA11_DICDI
AccessioniPrimary (citable) accession number: Q55FN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health