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Q55FL5

- SPTC1_DICDI

UniProt

Q55FL5 - SPTC1_DICDI

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Protein

Serine palmitoyltransferase 1

Gene
sptA, DDB_G0268056
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine By similarity.

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. serine C-palmitoyltransferase activity Source: dictyBase

GO - Biological processi

  1. sphingolipid biosynthetic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_204726. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 1 (EC:2.3.1.50)
Alternative name(s):
Long chain base biosynthesis protein 1
Short name:
LCB 1
Serine-palmitoyl-CoA transferase 1
Short name:
SPT 1
Short name:
SPT1
Gene namesi
Name:sptA
ORF Names:DDB_G0268056
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268056. sptA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Lumenal Reviewed predictionAdd
BLAST
Transmembranei17 – 3721Helical; Reviewed predictionAdd
BLAST
Topological domaini38 – 479442Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. serine C-palmitoyltransferase complex Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Serine palmitoyltransferase 1PRO_0000327870Add
BLAST

Proteomic databases

PRIDEiQ55FL5.

Interactioni

Subunit structurei

Forms a heterodimer with sptB By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0232040.

Structurei

3D structure databases

ProteinModelPortaliQ55FL5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0156.
KOiK00654.
OMAiRVFMDES.
PhylomeDBiQ55FL5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55FL5-1 [UniParc]FASTAAdd to Basket

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MFLFDIYNNI LYYTKEFIVT STSPNLFIHG LMAVFIIYLL TKRPFKPRQN    50
DTLTKAEEDE LIREWSPIPL TPKSNPLEVL NQTELIIQES EGTHVTINNK 100
KYLNLARSNY LGLINNPEIN KISENAIRKY GVGSCGPRGF YGTIDVHLDL 150
EKKTASFMKT PEAVLYSSAY ATISSAIPSF SKIGDIIIVD RGVSQPVQVG 200
VSLSRSRIYY FNHNDMDDLQ RVLEQTQFKG SKAKIVRKFV VIEGLYYNSG 250
TIAPLPQILK FKEQYKFRLI MDESHSVGVL GSTGRGLTEH YNIDTNLVDI 300
LTGSYGNSFS SGGGFCCGSP EVVYHQRLNG VGYVFSASLP PFLACSSTKA 350
IEMLEENPKM LEMLHSNIGE LYQGLNKSGA LNGLLEITSL PISPVIHLSL 400
LDSKSNKSNR INDELLLQKI VDKAMDYGLL LTRAKYVSAE KFIPKPSIRI 450
SVSSNLSSDQ IKQSIEIIKK CTSFVLESN 479
Length:479
Mass (Da):53,519
Last modified:May 24, 2005 - v1
Checksum:i10E6AFB435283F7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73481.1.
RefSeqiXP_647518.1. XM_642426.1.

Genome annotation databases

EnsemblProtistsiDDB0232040; DDB0232040; DDB_G0268056.
GeneIDi8616325.
KEGGiddi:DDB_G0268056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73481.1 .
RefSeqi XP_647518.1. XM_642426.1.

3D structure databases

ProteinModelPortali Q55FL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0232040.

Proteomic databases

PRIDEi Q55FL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0232040 ; DDB0232040 ; DDB_G0268056 .
GeneIDi 8616325.
KEGGi ddi:DDB_G0268056.

Organism-specific databases

dictyBasei DDB_G0268056. sptA.

Phylogenomic databases

eggNOGi COG0156.
KOi K00654.
OMAi RVFMDES.
PhylomeDBi Q55FL5.

Enzyme and pathway databases

UniPathwayi UPA00222 .
Reactomei REACT_204726. Sphingolipid de novo biosynthesis.

Miscellaneous databases

PROi Q55FL5.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSPTC1_DICDI
AccessioniPrimary (citable) accession number: Q55FL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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