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Q55FL5

- SPTC1_DICDI

UniProt

Q55FL5 - SPTC1_DICDI

Protein

Serine palmitoyltransferase 1

Gene

sptA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.By similarity

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: dictyBase

    GO - Biological processi

    1. sphingolipid biosynthetic process Source: dictyBase

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_204726. Sphingolipid de novo biosynthesis.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine palmitoyltransferase 1 (EC:2.3.1.50)
    Alternative name(s):
    Long chain base biosynthesis protein 1
    Short name:
    LCB 1
    Serine-palmitoyl-CoA transferase 1
    Short name:
    SPT 1
    Short name:
    SPT1
    Gene namesi
    Name:sptA
    ORF Names:DDB_G0268056
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0268056. sptA.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. serine C-palmitoyltransferase complex Source: dictyBase

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Serine palmitoyltransferase 1PRO_0000327870Add
    BLAST

    Proteomic databases

    PRIDEiQ55FL5.

    Interactioni

    Subunit structurei

    Forms a heterodimer with sptB.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0232040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55FL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616LumenalSequence AnalysisAdd
    BLAST
    Topological domaini38 – 479442CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0156.
    KOiK00654.
    OMAiRVFMDES.
    PhylomeDBiQ55FL5.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55FL5-1 [UniParc]FASTAAdd to Basket

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    MFLFDIYNNI LYYTKEFIVT STSPNLFIHG LMAVFIIYLL TKRPFKPRQN    50
    DTLTKAEEDE LIREWSPIPL TPKSNPLEVL NQTELIIQES EGTHVTINNK 100
    KYLNLARSNY LGLINNPEIN KISENAIRKY GVGSCGPRGF YGTIDVHLDL 150
    EKKTASFMKT PEAVLYSSAY ATISSAIPSF SKIGDIIIVD RGVSQPVQVG 200
    VSLSRSRIYY FNHNDMDDLQ RVLEQTQFKG SKAKIVRKFV VIEGLYYNSG 250
    TIAPLPQILK FKEQYKFRLI MDESHSVGVL GSTGRGLTEH YNIDTNLVDI 300
    LTGSYGNSFS SGGGFCCGSP EVVYHQRLNG VGYVFSASLP PFLACSSTKA 350
    IEMLEENPKM LEMLHSNIGE LYQGLNKSGA LNGLLEITSL PISPVIHLSL 400
    LDSKSNKSNR INDELLLQKI VDKAMDYGLL LTRAKYVSAE KFIPKPSIRI 450
    SVSSNLSSDQ IKQSIEIIKK CTSFVLESN 479
    Length:479
    Mass (Da):53,519
    Last modified:May 24, 2005 - v1
    Checksum:i10E6AFB435283F7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000003 Genomic DNA. Translation: EAL73481.1.
    RefSeqiXP_647518.1. XM_642426.1.

    Genome annotation databases

    EnsemblProtistsiDDB0232040; DDB0232040; DDB_G0268056.
    GeneIDi8616325.
    KEGGiddi:DDB_G0268056.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000003 Genomic DNA. Translation: EAL73481.1 .
    RefSeqi XP_647518.1. XM_642426.1.

    3D structure databases

    ProteinModelPortali Q55FL5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0232040.

    Proteomic databases

    PRIDEi Q55FL5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0232040 ; DDB0232040 ; DDB_G0268056 .
    GeneIDi 8616325.
    KEGGi ddi:DDB_G0268056.

    Organism-specific databases

    dictyBasei DDB_G0268056. sptA.

    Phylogenomic databases

    eggNOGi COG0156.
    KOi K00654.
    OMAi RVFMDES.
    PhylomeDBi Q55FL5.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_204726. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    PROi Q55FL5.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiSPTC1_DICDI
    AccessioniPrimary (citable) accession number: Q55FL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3