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Q55FL5 (SPTC1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine palmitoyltransferase 1

EC=2.3.1.50
Alternative name(s):
Long chain base biosynthesis protein 1
Short name=LCB 1
Serine-palmitoyl-CoA transferase 1
Short name=SPT 1
Short name=SPT1
Gene names
Name:sptA
ORF Names:DDB_G0268056
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine By similarity.

Catalytic activity

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Lipid metabolism; sphingolipid metabolism.

Subunit structure

Forms a heterodimer with sptB By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Serine palmitoyltransferase 1
PRO_0000327870

Regions

Topological domain1 – 1616Lumenal Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 479442Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q55FL5 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 10E6AFB435283F7D

FASTA47953,519
        10         20         30         40         50         60 
MFLFDIYNNI LYYTKEFIVT STSPNLFIHG LMAVFIIYLL TKRPFKPRQN DTLTKAEEDE 

        70         80         90        100        110        120 
LIREWSPIPL TPKSNPLEVL NQTELIIQES EGTHVTINNK KYLNLARSNY LGLINNPEIN 

       130        140        150        160        170        180 
KISENAIRKY GVGSCGPRGF YGTIDVHLDL EKKTASFMKT PEAVLYSSAY ATISSAIPSF 

       190        200        210        220        230        240 
SKIGDIIIVD RGVSQPVQVG VSLSRSRIYY FNHNDMDDLQ RVLEQTQFKG SKAKIVRKFV 

       250        260        270        280        290        300 
VIEGLYYNSG TIAPLPQILK FKEQYKFRLI MDESHSVGVL GSTGRGLTEH YNIDTNLVDI 

       310        320        330        340        350        360 
LTGSYGNSFS SGGGFCCGSP EVVYHQRLNG VGYVFSASLP PFLACSSTKA IEMLEENPKM 

       370        380        390        400        410        420 
LEMLHSNIGE LYQGLNKSGA LNGLLEITSL PISPVIHLSL LDSKSNKSNR INDELLLQKI 

       430        440        450        460        470 
VDKAMDYGLL LTRAKYVSAE KFIPKPSIRI SVSSNLSSDQ IKQSIEIIKK CTSFVLESN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000003 Genomic DNA. Translation: EAL73481.1.
RefSeqXP_647518.1. XM_642426.1.

3D structure databases

ProteinModelPortalQ55FL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0232040.

Proteomic databases

PRIDEQ55FL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0232040; DDB0232040; DDB_G0268056.
GeneID8616325.
KEGGddi:DDB_G0268056.

Organism-specific databases

dictyBaseDDB_G0268056. sptA.

Phylogenomic databases

eggNOGCOG0156.
OMARVFMDES.
PhylomeDBQ55FL5.

Enzyme and pathway databases

UniPathwayUPA00222.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
InterProIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Other

PROQ55FL5.

Entry information

Entry nameSPTC1_DICDI
AccessionPrimary (citable) accession number: Q55FL5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase