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Q55FL3 (ALRC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose reductase C

Short name=ARC
EC=1.1.1.21
Alternative name(s):
Aldehyde reductase C
Gene names
Name:alrC
ORF Names:DDB_G0268058
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies By similarity.

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from sequence or structural similarity. Source: dictyBase

   Molecular_functionalditol:NADP+ 1-oxidoreductase activity

Inferred from sequence or structural similarity. Source: dictyBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Aldose reductase C
PRO_0000327647

Regions

Nucleotide binding22 – 3110NADP Potential
Nucleotide binding227 – 28155NADP By similarity
Compositional bias4 – 1613Poly-Asn

Sites

Active site621Proton donor By similarity
Binding site1241Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55FL3 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 2C05C8761CB9377D

FASTA32136,529
        10         20         30         40         50         60 
MFQNNYNNNT NYNNNNFKLN DGNQIPSIGL GTYYSENPGE VGDAINNALK NGYRHIDGAA 

        70         80         90        100        110        120 
FYGNEKVIGN SLKEIFKEGE IKREDIFYTS KLWNSCHNSN LVVKHCVKTI EDLGIGYLDL 

       130        140        150        160        170        180 
YLIHWPIAFE NSNPLGLTIE PLRDQNGNPI IAPVSIRETW QEMEKLVELG LVKSIGVSNF 

       190        200        210        220        230        240 
NVQNLVDLLT YAKIKPVVNQ VEIHPYLTQF KLQEYCDKYE IKLVAYSPLG QGKCDFFSNK 

       250        260        270        280        290        300 
ILKSIAGKYK KSVANVIFKW LNQRGIAAIP KSGNHSRIIE NFNIFDFQLS NDDIEKINSL 

       310        320 
NANIRTCSPI TFFGTPFYLF D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000003 Genomic DNA. Translation: EAL73482.1.
RefSeqXP_647520.1. XM_642428.1.

3D structure databases

ProteinModelPortalQ55FL3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231284.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231284; DDB0231284; DDB_G0268058.
GeneID8616327.
KEGGddi:DDB_G0268058.

Organism-specific databases

dictyBaseDDB_G0268058. alrC.

Phylogenomic databases

eggNOGCOG0656.
OMANANIRTC.
PhylomeDBQ55FL3.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALRC_DICDI
AccessionPrimary (citable) accession number: Q55FL3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase