Q55FL3 (ALRC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldose reductase C
Short name=ARC
EC=1.1.1.21

Alternative name(s):
Aldehyde reductase C

Gene names

Name:	alrC
ORF Names:	DDB_G0268058

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies By similarity.
Catalytic activity	Alditol + NAD(P)+ = aldose + NAD(P)H.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	alditol:NADP+ 1-oxidoreductase activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Aldose reductase C		PRO_0000327647
Regions
	Nucleotide binding	22 – 31	10	NADP Potential
	Nucleotide binding	227 – 281	55	NADP By similarity
	Compositional bias	4 – 16	13	Poly-Asn
Sites
	Active site	62	1	Proton donor By similarity
	Binding site	124	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55FL3 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 2C05C8761CB9377D	FASTA	321	36,529
	10 20 30 40 50 60 MFQNNYNNNT NYNNNNFKLN DGNQIPSIGL GTYYSENPGE VGDAINNALK NGYRHIDGAA 70 80 90 100 110 120 FYGNEKVIGN SLKEIFKEGE IKREDIFYTS KLWNSCHNSN LVVKHCVKTI EDLGIGYLDL 130 140 150 160 170 180 YLIHWPIAFE NSNPLGLTIE PLRDQNGNPI IAPVSIRETW QEMEKLVELG LVKSIGVSNF 190 200 210 220 230 240 NVQNLVDLLT YAKIKPVVNQ VEIHPYLTQF KLQEYCDKYE IKLVAYSPLG QGKCDFFSNK 250 260 270 280 290 300 ILKSIAGKYK KSVANVIFKW LNQRGIAAIP KSGNHSRIIE NFNIFDFQLS NDDIEKINSL 310 320 NANIRTCSPI TFFGTPFYLF D

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000003 Genomic DNA. Translation: EAL73482.1.
RefSeq	XP_647520.1. XM_642428.1.
3D structure databases
HSSP	HSSP built from PDB template 1LWI based on UniProtKB P23457.
ProteinModelPortal	Q55FL3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231284; DDB0231284; DDB_G0268058.
GeneID	8616327.
GenomeReviews	Gene locus alrC in contig CM000150_GR.
KEGG	ddi:DDB_G0268058.
Organism-specific databases
dictyBase	DDB_G0268058. alrC.
Phylogenomic databases
eggNOG	KOG1577.
GeneTree	EPrGT00050000003304.
HOGENOM	HBG605727.
OMA	CELMEYL.
PhylomeDB	Q55FL3.
ProtClustDB	CLSZ2429209.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALRC_DICDI

Accession

Primary (citable) accession number: Q55FL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)