Reviewed,
UniProtKB/Swiss-Prot Q55FL3 (ALRC_DICDI)
Last modified
November 25, 2008.
Version 21.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Aldose reductase C Short name=ARC EC=1.1.1.21 Alternative name(s): Aldehyde reductase C | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 321 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies By similarity. |
| Catalytic activity | Alditol + NAD(P)(+) = aldose + NAD(P)H. |
| Sequence similarities | Belongs to the aldo/keto reductase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | aldehyde reductase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 321 | 321 | Aldose reductase C | PRO_0000327647 | |||||
Regions | |||||||||
| Nucleotide binding | 22 – 31 | 10 | NADP Potential | ||||||
| Nucleotide binding | 227 – 281 | 55 | NADP By similarity | ||||||
| Compositional bias | 4 – 16 | 13 | Poly-Asn | ||||||
Sites | |||||||||
| Active site | 62 | 1 | Proton donor By similarity | ||||||
| Binding site | 124 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
Cross-references
Sequence databases | |
|---|---|
| AAFI02000003 Genomic DNA. Translation: EAL73482.1. | |
| RefSeq | XP_647520.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3398524. |
| KEGG | ddi:DDB_0231284. |
Organism-specific databases | |
| dictyBase | DDB_G0268058. alrC. |
Family and domain databases | |
| InterPro | IPR001395. Aldo/ket_red. [Graphical view] |
| Gene3D | G3DSA:3.20.20.100. Aldo/ket_red. 1 hit. |
| PANTHER | PTHR11732. Aldo/ket_red. 1 hit. |
| Pfam | PF00248. Aldo_ket_red. 1 hit. [Graphical view] |
| PRINTS | PR00069. ALDKETRDTASE. |
| ProDom | PD000288. Aldo/ket_red. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALRC_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q55FL3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

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