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Protein

Aldose reductase C

Gene

alrC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.By similarity

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Proton donorBy similarity1
Binding sitei124SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 31NADPSequence analysis10
Nucleotide bindingi227 – 281NADPBy similarityAdd BLAST55

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-DDI-156590 Glutathione conjugation
R-DDI-193144 Estrogen biosynthesis
R-DDI-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-DDI-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-DDI-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-DDI-196108 Pregnenolone biosynthesis
R-DDI-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-DDI-5365859 RA biosynthesis pathway
R-DDI-5652227 Fructose biosynthesis
R-DDI-5661270 Catabolism of glucuronate to xylulose-5-phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase C (EC:1.1.1.21)
Short name:
ARC
Alternative name(s):
Aldehyde reductase C
Gene namesi
Name:alrC
ORF Names:DDB_G0268058
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268058 alrC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276471 – 321Aldose reductase CAdd BLAST321

Proteomic databases

PaxDbiQ55FL3

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231284

Structurei

3D structure databases

ProteinModelPortaliQ55FL3
SMRiQ55FL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 16Poly-AsnAdd BLAST13

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
InParanoidiQ55FL3
KOiK00011
OMAiWNTFHDG
PhylomeDBiQ55FL3

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q55FL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQNNYNNNT NYNNNNFKLN DGNQIPSIGL GTYYSENPGE VGDAINNALK
60 70 80 90 100
NGYRHIDGAA FYGNEKVIGN SLKEIFKEGE IKREDIFYTS KLWNSCHNSN
110 120 130 140 150
LVVKHCVKTI EDLGIGYLDL YLIHWPIAFE NSNPLGLTIE PLRDQNGNPI
160 170 180 190 200
IAPVSIRETW QEMEKLVELG LVKSIGVSNF NVQNLVDLLT YAKIKPVVNQ
210 220 230 240 250
VEIHPYLTQF KLQEYCDKYE IKLVAYSPLG QGKCDFFSNK ILKSIAGKYK
260 270 280 290 300
KSVANVIFKW LNQRGIAAIP KSGNHSRIIE NFNIFDFQLS NDDIEKINSL
310 320
NANIRTCSPI TFFGTPFYLF D
Length:321
Mass (Da):36,529
Last modified:May 24, 2005 - v1
Checksum:i2C05C8761CB9377D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA Translation: EAL73482.1
RefSeqiXP_647520.1, XM_642428.1

Genome annotation databases

EnsemblProtistsiEAL73482; EAL73482; DDB_G0268058
GeneIDi8616327
KEGGiddi:DDB_G0268058

Similar proteinsi

Entry informationi

Entry nameiALRC_DICDI
AccessioniPrimary (citable) accession number: Q55FL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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