Q55FJ6 (Y8078_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine/threonine-protein kinase DDB_G0268078
EC=2.7.11.22

Gene names

ORF Names:

DDB_G0268078

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Probable serine/threonine-protein kinase DDB_G0268078		PRO_0000358903
Regions
	Domain	4 – 286	283	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
	Compositional bias	326 – 336	11	Poly-Asn
	Compositional bias	381 – 392	12	Poly-Asn
	Compositional bias	415 – 419	5	Poly-Gln
	Compositional bias	430 – 449	20	Pro-rich
	Compositional bias	453 – 467	15	Poly-Gln
Sites
	Active site	125	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55FJ6 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 26AA757DBDFA9841	FASTA	507	58,510
	10 20 30 40 50 60 MEKYQFIKQV GDGAYGDVIK AIDVKTGEIV AIKRMKKKFS DWKECIQLRE IKALKKLKHP 70 80 90 100 110 120 NIVKLLEIIL ERDELFFVFE YLENNLYESI KDRTKLLPET TIRNIIYQIL QALHFMHTNG 130 140 150 160 170 180 FFHRDLKPEN IMLVGERLKI ADFGLAREIE SKPPFTDYIS TRWYRAPEVL LRCTYYNAPI 190 200 210 220 230 240 DIWAVGAIMA ELYSLKPMFP GSSEIDQLFK ICTIMGSPTS ATWIDGIKLA NSMGFTFPNV 250 260 270 280 290 300 QPPSINPLST LLPNANQDAI ELITDLLQYD PLKRPTPLQA LQHRYFKVSI PSSILLKPNF 310 320 330 340 350 360 IELSNKYLIK NGYINNNINN NSNYSNNNNN NNLNSNSENL NNVNKNNQQP HSPQKIQTPK 370 380 390 400 410 420 PKNSFLRKSR YSYLNNVSLE NVNNNNNNYN SNTTSGYYNQ KLDSTPRLSP RIVRQQQQQI 430 440 450 460 470 480 LLPLIIQQQP PPQSQPPQSQ PPPQSQPPPI LTQQQQQQQQ QQQQQQQLPS KTTIYHNTNH 490 500 LNAPIPPNHQ RGISPQFYNE TTNNSKL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000003 Genomic DNA. Translation: EAL73492.1.
RefSeq	XP_647537.1. XM_642445.1.
3D structure databases
HSSP	HSSP built from PDB template 1PYE based on UniProtKB P24941.
ProteinModelPortal	Q55FJ6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0229430; DDB0229430; DDB_G0268078.
GeneID	8616344.
KEGG	ddi:DDB_G0268078.
Organism-specific databases
dictyBase	DDB_G0268078.
Phylogenomic databases
eggNOG	COG0515.
KO	K08829.
OMA	AQITIVE.
ProtClustDB	CLSZ2846954.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y8078_DICDI

Accession

Primary (citable) accession number: Q55FJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)