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Q55FI1

- GABT_DICDI

UniProt

Q55FI1 - GABT_DICDI

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Protein

4-aminobutyrate aminotransferase

Gene

gabT

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. 4-aminobutyrate transaminase activity Source: dictyBase
  2. protein homodimerization activity Source: UniProtKB
  3. pyridoxal phosphate binding Source: UniProtKB

GO - Biological processi

  1. gamma-aminobutyric acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_203473. Degradation of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Gene namesi
Name:gabT
ORF Names:DDB_G0268104
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268104. gabT.

Subcellular locationi

GO - Cellular componenti

  1. 4-aminobutyrate transaminase complex Source: UniProtKB
  2. mitochondrion Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4954954-aminobutyrate aminotransferasePRO_0000327473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei350 – 3501N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ55FI1.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231448.

Structurei

3D structure databases

ProteinModelPortaliQ55FI1.
SMRiQ55FI1. Positions 36-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0160.
InParanoidiQ55FI1.
KOiK13524.
OMAiKLIQQPQ.
PhylomeDBiQ55FI1.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55FI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSRLIKCL SSNNYIVRSF SKSSIPTTPT PDFPGEYKEP IVKTQIPGPQ
60 70 80 90 100
SKALIERLNK LQDPRAAHFF ADYANSRGNY ISDVDGNILL DLYCQIASIP
110 120 130 140 150
IGYNNPELIK AAKSDRWVSA IINRPSLGVL PPKDWPALIE NSFMQVSPKG
160 170 180 190 200
LNQVFTAMCG SCANECAYKA VFMHYQHVKR GGKPFTPEEL SSCMKNQEPG
210 220 230 240 250
SPSLSILSFK KGFHGRTFGT LSTTRSKAIH KLDIPAFDWP AATFPDLKYP
260 270 280 290 300
LAEHAKENRE IEDRCLQEVE QLIKTWHIPV AGIIVEPIQA EGGDNYATPY
310 320 330 340 350
FFQGLRDITK KHGVSMIVDE VQTGMGATGK FWAHEHWNLT SPPDIVTFSK
360 370 380 390 400
KMQAAGFYHN LDYRPSESYR NFNTWMGDPV RALELEVVIG EIKKNHLLDN
410 420 430 440 450
VVITGNYLKD GLFDIAARYP GLIQNIRGEG TFLAIDFPTP AERDRVISHI
460 470 480 490
RLLGVEMGGC GERSIRFRPM LVCQPSHINQ FLNRFDQTMK ELYKN
Length:495
Mass (Da):55,692
Last modified:May 24, 2005 - v1
Checksum:iD79738D198B10CE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73505.1.
RefSeqiXP_647552.1. XM_642460.1.

Genome annotation databases

EnsemblProtistsiDDB0231448; DDB0231448; DDB_G0268104.
GeneIDi8616360.
KEGGiddi:DDB_G0268104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73505.1 .
RefSeqi XP_647552.1. XM_642460.1.

3D structure databases

ProteinModelPortali Q55FI1.
SMRi Q55FI1. Positions 36-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231448.

Proteomic databases

PRIDEi Q55FI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231448 ; DDB0231448 ; DDB_G0268104 .
GeneIDi 8616360.
KEGGi ddi:DDB_G0268104.

Organism-specific databases

dictyBasei DDB_G0268104. gabT.

Phylogenomic databases

eggNOGi COG0160.
InParanoidi Q55FI1.
KOi K13524.
OMAi KLIQQPQ.
PhylomeDBi Q55FI1.

Enzyme and pathway databases

Reactomei REACT_203473. Degradation of GABA.

Miscellaneous databases

PROi Q55FI1.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00699. GABAtrns_euk. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGABT_DICDI
AccessioniPrimary (citable) accession number: Q55FI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3