Q55FI1 (GABT_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-aminobutyrate aminotransferase
EC=2.6.1.19

Alternative name(s):
GABA aminotransferase
Short name=GABA-AT
Gamma-amino-N-butyrate transaminase
Short name=GABA transaminase

Gene names

Name:	gabT
ORF Names:	DDB_G0268104

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	4-aminobutyrate transaminase complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	4-aminobutyrate transaminase activity Inferred from sequence or structural similarity. Source: dictyBase protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB pyridoxal phosphate binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	4-aminobutyrate aminotransferase		PRO_0000327473
Amino acid modifications
	Modified residue	350	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55FI1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: D79738D198B10CE1	FASTA	495	55,692
	10 20 30 40 50 60 MSSSRLIKCL SSNNYIVRSF SKSSIPTTPT PDFPGEYKEP IVKTQIPGPQ SKALIERLNK 70 80 90 100 110 120 LQDPRAAHFF ADYANSRGNY ISDVDGNILL DLYCQIASIP IGYNNPELIK AAKSDRWVSA 130 140 150 160 170 180 IINRPSLGVL PPKDWPALIE NSFMQVSPKG LNQVFTAMCG SCANECAYKA VFMHYQHVKR 190 200 210 220 230 240 GGKPFTPEEL SSCMKNQEPG SPSLSILSFK KGFHGRTFGT LSTTRSKAIH KLDIPAFDWP 250 260 270 280 290 300 AATFPDLKYP LAEHAKENRE IEDRCLQEVE QLIKTWHIPV AGIIVEPIQA EGGDNYATPY 310 320 330 340 350 360 FFQGLRDITK KHGVSMIVDE VQTGMGATGK FWAHEHWNLT SPPDIVTFSK KMQAAGFYHN 370 380 390 400 410 420 LDYRPSESYR NFNTWMGDPV RALELEVVIG EIKKNHLLDN VVITGNYLKD GLFDIAARYP 430 440 450 460 470 480 GLIQNIRGEG TFLAIDFPTP AERDRVISHI RLLGVEMGGC GERSIRFRPM LVCQPSHINQ 490 FLNRFDQTMK ELYKN

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000003 Genomic DNA. Translation: EAL73505.1.
RefSeq	XP_647552.1. XM_642460.1.
3D structure databases
ProteinModelPortal	Q55FI1.
SMR	Q55FI1. Positions 36-492.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0231448.
Proteomic databases
PRIDE	Q55FI1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231448; DDB0231448; DDB_G0268104.
GeneID	8616360.
KEGG	ddi:DDB_G0268104.
Organism-specific databases
dictyBase	DDB_G0268104. gabT.
Phylogenomic databases
eggNOG	COG0160.
KO	K13524.
OMA	RLACSFQ.
ProtClustDB	CLSZ2729370.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
InterPro	IPR004631. 4NH2But_aminotransferase_euk. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF6. PTHR11986:SF6. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00699. GABAtrns_euk. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABT_DICDI

Accession

Primary (citable) accession number: Q55FI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)