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Protein

4-aminobutyrate aminotransferase

Gene

gabT

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei216SubstrateBy similarity1
Binding sitei374Pyridoxal phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-916853 Degradation of GABA

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Gene namesi
Name:gabT
ORF Names:DDB_G0268104
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268104 gabT

Subcellular locationi

GO - Cellular componenti

  • 4-aminobutyrate transaminase complex Source: UniProtKB
  • mitochondrion Source: dictyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003274731 – 4954-aminobutyrate aminotransferaseAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei350N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ55FI1
PRIDEiQ55FI1

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0231448

Structurei

3D structure databases

ProteinModelPortaliQ55FI1
SMRiQ55FI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 161Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1405 Eukaryota
COG0160 LUCA
InParanoidiQ55FI1
KOiK13524
OMAiIQTGGCG
PhylomeDBiQ55FI1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004631 4NH2But_aminotransferase_euk
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00699 GABAtrns_euk, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q55FI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSRLIKCL SSNNYIVRSF SKSSIPTTPT PDFPGEYKEP IVKTQIPGPQ
60 70 80 90 100
SKALIERLNK LQDPRAAHFF ADYANSRGNY ISDVDGNILL DLYCQIASIP
110 120 130 140 150
IGYNNPELIK AAKSDRWVSA IINRPSLGVL PPKDWPALIE NSFMQVSPKG
160 170 180 190 200
LNQVFTAMCG SCANECAYKA VFMHYQHVKR GGKPFTPEEL SSCMKNQEPG
210 220 230 240 250
SPSLSILSFK KGFHGRTFGT LSTTRSKAIH KLDIPAFDWP AATFPDLKYP
260 270 280 290 300
LAEHAKENRE IEDRCLQEVE QLIKTWHIPV AGIIVEPIQA EGGDNYATPY
310 320 330 340 350
FFQGLRDITK KHGVSMIVDE VQTGMGATGK FWAHEHWNLT SPPDIVTFSK
360 370 380 390 400
KMQAAGFYHN LDYRPSESYR NFNTWMGDPV RALELEVVIG EIKKNHLLDN
410 420 430 440 450
VVITGNYLKD GLFDIAARYP GLIQNIRGEG TFLAIDFPTP AERDRVISHI
460 470 480 490
RLLGVEMGGC GERSIRFRPM LVCQPSHINQ FLNRFDQTMK ELYKN
Length:495
Mass (Da):55,692
Last modified:May 24, 2005 - v1
Checksum:iD79738D198B10CE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA Translation: EAL73505.1
RefSeqiXP_647552.1, XM_642460.1

Genome annotation databases

EnsemblProtistsiEAL73505; EAL73505; DDB_G0268104
GeneIDi8616360
KEGGiddi:DDB_G0268104

Similar proteinsi

Entry informationi

Entry nameiGABT_DICDI
AccessioniPrimary (citable) accession number: Q55FI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health