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Q55FI1

- GABT_DICDI

UniProt

Q55FI1 - GABT_DICDI

Protein

4-aminobutyrate aminotransferase

Gene

gabT

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. 4-aminobutyrate transaminase activity Source: dictyBase
    2. protein homodimerization activity Source: UniProtKB
    3. pyridoxal phosphate binding Source: UniProtKB

    GO - Biological processi

    1. gamma-aminobutyric acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_203473. Degradation of GABA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-aminobutyrate aminotransferase (EC:2.6.1.19)
    Alternative name(s):
    GABA aminotransferase
    Short name:
    GABA-AT
    Gamma-amino-N-butyrate transaminase
    Short name:
    GABA transaminase
    Gene namesi
    Name:gabT
    ORF Names:DDB_G0268104
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0268104. gabT.

    Subcellular locationi

    GO - Cellular componenti

    1. 4-aminobutyrate transaminase complex Source: UniProtKB
    2. mitochondrion Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4954954-aminobutyrate aminotransferasePRO_0000327473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei350 – 3501N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ55FI1.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231448.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55FI1.
    SMRiQ55FI1. Positions 36-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0160.
    KOiK13524.
    OMAiKLIQQPQ.
    PhylomeDBiQ55FI1.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProiIPR004631. 4NH2But_aminotransferase_euk.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PTHR11986:SF6. PTHR11986:SF6. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55FI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSRLIKCL SSNNYIVRSF SKSSIPTTPT PDFPGEYKEP IVKTQIPGPQ    50
    SKALIERLNK LQDPRAAHFF ADYANSRGNY ISDVDGNILL DLYCQIASIP 100
    IGYNNPELIK AAKSDRWVSA IINRPSLGVL PPKDWPALIE NSFMQVSPKG 150
    LNQVFTAMCG SCANECAYKA VFMHYQHVKR GGKPFTPEEL SSCMKNQEPG 200
    SPSLSILSFK KGFHGRTFGT LSTTRSKAIH KLDIPAFDWP AATFPDLKYP 250
    LAEHAKENRE IEDRCLQEVE QLIKTWHIPV AGIIVEPIQA EGGDNYATPY 300
    FFQGLRDITK KHGVSMIVDE VQTGMGATGK FWAHEHWNLT SPPDIVTFSK 350
    KMQAAGFYHN LDYRPSESYR NFNTWMGDPV RALELEVVIG EIKKNHLLDN 400
    VVITGNYLKD GLFDIAARYP GLIQNIRGEG TFLAIDFPTP AERDRVISHI 450
    RLLGVEMGGC GERSIRFRPM LVCQPSHINQ FLNRFDQTMK ELYKN 495
    Length:495
    Mass (Da):55,692
    Last modified:May 24, 2005 - v1
    Checksum:iD79738D198B10CE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000003 Genomic DNA. Translation: EAL73505.1.
    RefSeqiXP_647552.1. XM_642460.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231448; DDB0231448; DDB_G0268104.
    GeneIDi8616360.
    KEGGiddi:DDB_G0268104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000003 Genomic DNA. Translation: EAL73505.1 .
    RefSeqi XP_647552.1. XM_642460.1.

    3D structure databases

    ProteinModelPortali Q55FI1.
    SMRi Q55FI1. Positions 36-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231448.

    Proteomic databases

    PRIDEi Q55FI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231448 ; DDB0231448 ; DDB_G0268104 .
    GeneIDi 8616360.
    KEGGi ddi:DDB_G0268104.

    Organism-specific databases

    dictyBasei DDB_G0268104. gabT.

    Phylogenomic databases

    eggNOGi COG0160.
    KOi K13524.
    OMAi KLIQQPQ.
    PhylomeDBi Q55FI1.

    Enzyme and pathway databases

    Reactomei REACT_203473. Degradation of GABA.

    Miscellaneous databases

    PROi Q55FI1.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProi IPR004631. 4NH2But_aminotransferase_euk.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    PTHR11986:SF6. PTHR11986:SF6. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00699. GABAtrns_euk. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiGABT_DICDI
    AccessioniPrimary (citable) accession number: Q55FI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3