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Protein

Putative glutathione S-transferase alpha-1

Gene

gsta1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10GlutathioneBy similarity1
Binding sitei44GlutathioneBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutathione S-transferase alpha-1 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha 1
Gene namesi
Name:gsta1
ORF Names:DDB_G0268138
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268138.

Subcellular locationi

GO - Cellular componenti

  • phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003507382 – 202Putative glutathione S-transferase alpha-1Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ55FF3.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231431.

Structurei

3D structure databases

ProteinModelPortaliQ55FF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 81GST N-terminalAdd BLAST78
Domaini83 – 200GST C-terminalAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 52Glutathione bindingBy similarity2
Regioni65 – 66Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IN59. Eukaryota.
ENOG410Y9SU. LUCA.
InParanoidiQ55FF3.
KOiK00799.
OMAiAICKYIA.
PhylomeDBiQ55FF3.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55FF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNKPSFSY FKVLVLGQLP RFTLNYFGTD FTDNYVESID DEFRKTLKFG
60 70 80 90 100
QLPLFVDSDG FRLTQTDAIC KYIAAKHDFL GKSIKERAIV DETIAAVHDD
110 120 130 140 150
VIIPGYKVGK GVEDKKVIDT IISRHFTTFE NVLAENKFIA GGDNYTLADL
160 170 180 190 200
YVFVAYHYYK HLGHSEKFQN KFPHLEALQA HFESNKGIAE YIKNRPDSGR

GI
Length:202
Mass (Da):23,063
Last modified:May 24, 2005 - v1
Checksum:iACA3DDF0E4738949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73522.1.
RefSeqiXP_647580.1. XM_642488.1.

Genome annotation databases

EnsemblProtistsiEAL73522; EAL73522; DDB_G0268138.
GeneIDi8616392.
KEGGiddi:DDB_G0268138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000003 Genomic DNA. Translation: EAL73522.1.
RefSeqiXP_647580.1. XM_642488.1.

3D structure databases

ProteinModelPortaliQ55FF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231431.

Proteomic databases

PaxDbiQ55FF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL73522; EAL73522; DDB_G0268138.
GeneIDi8616392.
KEGGiddi:DDB_G0268138.

Organism-specific databases

dictyBaseiDDB_G0268138.

Phylogenomic databases

eggNOGiENOG410IN59. Eukaryota.
ENOG410Y9SU. LUCA.
InParanoidiQ55FF3.
KOiK00799.
OMAiAICKYIA.
PhylomeDBiQ55FF3.

Miscellaneous databases

PROiQ55FF3.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTA1_DICDI
AccessioniPrimary (citable) accession number: Q55FF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.