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Protein

3'(2'),5'-bisphosphate nucleotidase

Gene

DDB_G0268652

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (By similarity).By similarity

Catalytic activityi

Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi73Magnesium 1By similarity1
Binding sitei73SubstrateBy similarity1
Metal bindingi129Magnesium 1By similarity1
Metal bindingi129Magnesium 2By similarity1
Metal bindingi131Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi132Magnesium 2By similarity1
Metal bindingi274Magnesium 2By similarity1
Binding sitei274SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3'(2'),5'-bisphosphate nucleotidase (EC:3.1.3.7)
Alternative name(s):
3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
DPNPase
Inositol polyphosphate 1-phosphatase
Short name:
IPPase
Inositol-1,4-bisphosphate 1-phosphatase (EC:3.1.3.57)
Gene namesi
ORF Names:DDB_G0268652
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268652. ippB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003275191 – 3323'(2'),5'-bisphosphate nucleotidaseAdd BLAST332

Proteomic databases

PaxDbiQ55F34.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238884.

Structurei

3D structure databases

ProteinModelPortaliQ55F34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 134Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiKOG1528. Eukaryota.
COG1218. LUCA.
InParanoidiQ55F34.
KOiK15422.
OMAiAGHIIVE.
PhylomeDBiQ55F34.

Family and domain databases

InterProiIPR006239. Bisphos_HAL2.
IPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
TIGRFAMsiTIGR01330. bisphos_HAL2. 1 hit.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55F34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCNLAKIR SVAIKAVEKA CIACLDIQKQ LISEDTINKK DQSPVTVGDY
60 70 80 90 100
TVQALVINEL LKGLDEEYPI IAEEDSKTLS SQKDVESKVL SFFNRYSNES
110 120 130 140 150
FVESQLSSLL DKGNKKKDLN SSNRWWTLDP IDGTLGFLRK DQYAVALALM
160 170 180 190 200
EDNKPILGIL GCPNLPVSKG STEKGCIFVG LKNKGSFMIK LSNLDQEEPI
210 220 230 240 250
KVSNQSDPTK AIFTESFVSR GFGHELNQKI SNSMGVTAEP LKIDSQCKYA
260 270 280 290 300
MVARGDSDCY LRLTQLDYKE CIWDHAAGHI IVEEAGGIVT DFKKQQLDYS
310 320 330
KGFKLENNVG IVCSNKLLND SLFDSIKKSI QF
Length:332
Mass (Da):36,888
Last modified:May 24, 2005 - v1
Checksum:i56F8D137C9244277
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000004 Genomic DNA. Translation: EAL72915.1.
RefSeqiXP_646836.1. XM_641744.1.

Genome annotation databases

EnsemblProtistsiEAL72915; EAL72915; DDB_G0268652.
GeneIDi8616518.
KEGGiddi:DDB_G0268652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000004 Genomic DNA. Translation: EAL72915.1.
RefSeqiXP_646836.1. XM_641744.1.

3D structure databases

ProteinModelPortaliQ55F34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238884.

Proteomic databases

PaxDbiQ55F34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL72915; EAL72915; DDB_G0268652.
GeneIDi8616518.
KEGGiddi:DDB_G0268652.

Organism-specific databases

dictyBaseiDDB_G0268652. ippB.

Phylogenomic databases

eggNOGiKOG1528. Eukaryota.
COG1218. LUCA.
InParanoidiQ55F34.
KOiK15422.
OMAiAGHIIVE.
PhylomeDBiQ55F34.

Miscellaneous databases

PROiQ55F34.

Family and domain databases

InterProiIPR006239. Bisphos_HAL2.
IPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
TIGRFAMsiTIGR01330. bisphos_HAL2. 1 hit.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPNP_DICDI
AccessioniPrimary (citable) accession number: Q55F34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.