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Protein

Aspartate aminotransferase, mitochondrial

Gene

aatA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity).By similarity

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60Substrate; via amide nitrogenBy similarity1
Binding sitei156SubstrateBy similarity1
Binding sitei209SubstrateBy similarity1
Binding sitei401SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase, mitochondrial (EC:2.6.1.1, EC:2.6.1.7)
Alternative name(s):
Kynurenine aminotransferase 4
Kynurenine aminotransferase IV
Kynurenine--oxoglutarate transaminase 4
Kynurenine--oxoglutarate transaminase IV
Transaminase A
Gene namesi
Name:aatA
ORF Names:DDB_G0268664
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268664. aatA.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000032759730 – 426Aspartate aminotransferase, mitochondrialAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ55F21.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230092.

Structurei

3D structure databases

ProteinModelPortaliQ55F21.
SMRiQ55F21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1411. Eukaryota.
COG1448. LUCA.
InParanoidiQ55F21.
KOiK14455.
OMAiELFKEWT.
PhylomeDBiQ55F21.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiView protein in InterPro
IPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00105. AA_TRANSFER_CLASS_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55F21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRSARLISN IKFGQKNIRQ FSTNTNWWAN VQKGPEDPIL GVSIAYNKDT
60 70 80 90 100
SPSKINLGVG AYRDENGKPY VLDCVKKADK KIYEANVDHE YAPIVGVAAF
110 120 130 140 150
NQLAAQLALG EECKHIKEKR IATVQSISGT GALRIAADFF ARFLKGKTAY
160 170 180 190 200
VPNPTWGNHN VIFNDAGIPV KSYGYYNPAT CGLNFEAMTK DIAAAPEGSI
210 220 230 240 250
ILLHACAHNP TGVDPTAEQW KKISEICKER GHFVLFDFAY QGFASGSPEK
260 270 280 290 300
DAAAVRMFVE DGHNIALCQS FAKNFGLYGE RIGAFSILTE TSDQALNVES
310 320 330 340 350
QLKILIRPMY SNPPVYGARL VQAILKDKEL TNEWRSEVKG MADRIINMRE
360 370 380 390 400
QLVKYLKKHG STRDWSHITT QIGMFCFTGL TPEQVDRLAN EYHIYLTRNG
410 420
RISIAGINST NVEYLAKAMA AVTKDN
Length:426
Mass (Da):47,285
Last modified:May 24, 2005 - v1
Checksum:i6E446EFFF83FD8CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000004 Genomic DNA. Translation: EAL72921.1.
RefSeqiXP_646849.1. XM_641757.1.

Genome annotation databases

EnsemblProtistsiEAL72921; EAL72921; DDB_G0268664.
GeneIDi8616532.
KEGGiddi:DDB_G0268664.

Similar proteinsi

Entry informationi

Entry nameiAATM_DICDI
AccessioniPrimary (citable) accession number: Q55F21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families