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Q55EY8 (UBE2W_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin-conjugating enzyme E2 W

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein W
Ubiquitin-protein ligase W
Gene names
Name:ube2w
ORF Names:DDB_G0268938
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 149149Probable ubiquitin-conjugating enzyme E2 W
PRO_0000327426

Sites

Active site881Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55EY8 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 414FE2B9768526A6

FASTA14916,818
        10         20         30         40         50         60 
MTSRYAKRLQ KELLDLKTNP PPCISITEGD NLDKWVIAVD GTEGSIYQGE HFKLQFKFSS 

        70         80         90        100        110        120 
GYPLDSPEVI FIGTPPIHPH IYSNGHICLS ILYDNWSPAL TVSSVCLSIL SMLSGCTEKI 

       130        140 
RPTDDSKYVS RVLNKSPKEV RWMFHDDTV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000004 Genomic DNA. Translation: EAL73058.1.

3D structure databases

ProteinModelPortalQ55EY8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0202295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0238664; DDB0238664; DDB_G0268938.
KEGGddi:DDB_G0268938.

Organism-specific databases

dictyBaseDDB_G0268938. ube2w.

Phylogenomic databases

eggNOGCOG5078.
KOK10688.
OMAFTGDNIP.
PhylomeDBQ55EY8.
ProtClustDBCLSZ2431475.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ55EY8.

Entry information

Entry nameUBE2W_DICDI
AccessionPrimary (citable) accession number: Q55EY8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase