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Q55ER0

- MANC_DICDI

UniProt

Q55ER0 - MANC_DICDI

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Protein

Alpha-mannosidase C

Gene
manC, DDB_G0268994
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Zinc By similarity
Metal bindingi46 – 461Zinc By similarity
Active sitei158 – 1581Nucleophile By similarity
Metal bindingi158 – 1581Zinc By similarity
Metal bindingi475 – 4751Zinc By similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_221646. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase C (EC:3.2.1.24)
Gene namesi
Name:manC
ORF Names:DDB_G0268994
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268994. manC.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 10791057Alpha-mannosidase CPRO_0000327842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi467 – 4671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi527 – 5271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi589 – 5891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi760 – 7601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi769 – 7691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi848 – 8481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi872 – 8721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi912 – 9121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1040 – 10401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1057 – 10571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231613.

Structurei

3D structure databases

ProteinModelPortaliQ55ER0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi357 – 3648Poly-Thr
Compositional biasi437 – 4415Poly-Asn
Compositional biasi442 – 4509Poly-Asp
Compositional biasi648 – 66922Ser-richAdd
BLAST
Compositional biasi754 – 78431Thr-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0383.
OMAiSCNNTII.
PhylomeDBiQ55ER0.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 2 hits.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 2 hits.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55ER0-1 [UniParc]FASTAAdd to Basket

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MFYKTFGFLF IYLIILISGT LSQKEIDSSN EQPVIEVFLV PHSHCDVGWL     50
KTVEQYYTEN VTLILNNVIE TLTKDKSKKF NWAEIIYFER WWNDQNETLQ 100
NQVKQLISNK QFYFVGGGWT QNDEAITDYQ AVINQMTLGH QFLFNQFGIK 150
PEIGWQIDPF GPSTLTPTLF KLMGFKYHVI NRIDERIKYI FNATEMNIPE 200
SGIMTIEREF EFLWYPSSNN PNISIFTHVL DHHYESPSLT IVDYEIPNLT 250
YTSGFDFEGN PKINPPITIL NLRFRADLLV KIIKERIDLF RHNNLLLPFG 300
GDFRFQDSKI EFNNMDKLIK FINSNQKTYG VNIKYSTVDE YFEKVIQDTN 350
INWKEDTTTT TTTTIPIGGD EFPKLSNLDY FDYTKCDYND YQKYKTCSLY 400
YSGFFSSYSE LKQISRQSDS LLRIGEFLYS FANLISNNNN NDDDDDDDND 450
FNIQLKEISN ILVQHRNVSG ILTHHDAITG TAKTKVRDDY LLMLNQVQSN 500
TMNNVIPNIV GYLLSNKSIQ NFDYSCNNTI IMNSPQIGDI FSISFTNSLG 550
WDRSEYIQIQ LPPSTIVTVY NYNLISIQSQ IVQRFDKDNQ TFLYFNVETP 600
SLGISTYFII ITSTNDDNVD DDVDKVFGDD ELLIYLLKNG ILSKPILSEI 650
SEISELSSSS SSSSSSSSSQ ITIGNSKFNL NFNYLNENYN LLTLTSFDDL 700
IENEYSIPIT QNYIEYISGN DNSYIFKPSG LPVNLKPESP KFYKVTGSLV 750
QMITILYTNN CSQTYIVYNS TTTTTTTTTT TTTTNNDDSP PLELINDEQY 800
FEIDNIVAAG WNKEIGSQFS SESINNDKTF YTSNGLELIE RNYKSLFNDT 850
TEFNMIAGNY YPVINTIQIL DNKSKKQLTI LTKQSFGASS QNNGELNLLF 900
IRRSTDQFVT LNETMNDISN PLIKIKVLFG NSNSIENIRT PHSLLLENPL 950
LPIYSIVSDI TIDKWISIYN TVFKPFKTSL PYNLHLLTFT KQQQQQQQDF 1000
NEDNPLDYFI RFLNIYEISQ SESFSQPIEF KLTNYFNNFN ITNIRESSLT 1050
FNSIINNNTN SIILNPLNLI SLIITISKN 1079
Length:1,079
Mass (Da):124,433
Last modified:May 24, 2005 - v1
Checksum:iAFD4C59A88DDC0C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000004 Genomic DNA. Translation: EAL73086.1.
RefSeqiXP_646960.1. XM_641868.1.

Genome annotation databases

EnsemblProtistsiDDB0231613; DDB0231613; DDB_G0268994.
GeneIDi8616650.
KEGGiddi:DDB_G0268994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000004 Genomic DNA. Translation: EAL73086.1 .
RefSeqi XP_646960.1. XM_641868.1.

3D structure databases

ProteinModelPortali Q55ER0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231613.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231613 ; DDB0231613 ; DDB_G0268994 .
GeneIDi 8616650.
KEGGi ddi:DDB_G0268994.

Organism-specific databases

dictyBasei DDB_G0268994. manC.

Phylogenomic databases

eggNOGi COG0383.
OMAi SCNNTII.
PhylomeDBi Q55ER0.

Enzyme and pathway databases

Reactomei REACT_221646. Reactions specific to the complex N-glycan synthesis pathway.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
2.60.40.1180. 2 hits.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 2 hits.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMANC_DICDI
AccessioniPrimary (citable) accession number: Q55ER0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3