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Protein

Alpha-mannosidase C

Gene

manC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441ZincBy similarity
Metal bindingi46 – 461ZincBy similarity
Active sitei158 – 1581NucleophileBy similarity
Metal bindingi158 – 1581ZincBy similarity
Metal bindingi475 – 4751ZincBy similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase C (EC:3.2.1.24)
Gene namesi
Name:manC
ORF Names:DDB_G0268994
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0268994. manC.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 10791057Alpha-mannosidase CPRO_0000327842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi760 – 7601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi769 – 7691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi872 – 8721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi912 – 9121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1040 – 10401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1057 – 10571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231613.

Structurei

3D structure databases

ProteinModelPortaliQ55ER0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi357 – 3648Poly-Thr
Compositional biasi437 – 4415Poly-Asn
Compositional biasi442 – 4509Poly-Asp
Compositional biasi648 – 66922Ser-richAdd
BLAST
Compositional biasi754 – 78431Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0383.
InParanoidiQ55ER0.
OMAiSCNNTII.
PhylomeDBiQ55ER0.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 2 hits.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 2 hits.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55ER0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYKTFGFLF IYLIILISGT LSQKEIDSSN EQPVIEVFLV PHSHCDVGWL
60 70 80 90 100
KTVEQYYTEN VTLILNNVIE TLTKDKSKKF NWAEIIYFER WWNDQNETLQ
110 120 130 140 150
NQVKQLISNK QFYFVGGGWT QNDEAITDYQ AVINQMTLGH QFLFNQFGIK
160 170 180 190 200
PEIGWQIDPF GPSTLTPTLF KLMGFKYHVI NRIDERIKYI FNATEMNIPE
210 220 230 240 250
SGIMTIEREF EFLWYPSSNN PNISIFTHVL DHHYESPSLT IVDYEIPNLT
260 270 280 290 300
YTSGFDFEGN PKINPPITIL NLRFRADLLV KIIKERIDLF RHNNLLLPFG
310 320 330 340 350
GDFRFQDSKI EFNNMDKLIK FINSNQKTYG VNIKYSTVDE YFEKVIQDTN
360 370 380 390 400
INWKEDTTTT TTTTIPIGGD EFPKLSNLDY FDYTKCDYND YQKYKTCSLY
410 420 430 440 450
YSGFFSSYSE LKQISRQSDS LLRIGEFLYS FANLISNNNN NDDDDDDDND
460 470 480 490 500
FNIQLKEISN ILVQHRNVSG ILTHHDAITG TAKTKVRDDY LLMLNQVQSN
510 520 530 540 550
TMNNVIPNIV GYLLSNKSIQ NFDYSCNNTI IMNSPQIGDI FSISFTNSLG
560 570 580 590 600
WDRSEYIQIQ LPPSTIVTVY NYNLISIQSQ IVQRFDKDNQ TFLYFNVETP
610 620 630 640 650
SLGISTYFII ITSTNDDNVD DDVDKVFGDD ELLIYLLKNG ILSKPILSEI
660 670 680 690 700
SEISELSSSS SSSSSSSSSQ ITIGNSKFNL NFNYLNENYN LLTLTSFDDL
710 720 730 740 750
IENEYSIPIT QNYIEYISGN DNSYIFKPSG LPVNLKPESP KFYKVTGSLV
760 770 780 790 800
QMITILYTNN CSQTYIVYNS TTTTTTTTTT TTTTNNDDSP PLELINDEQY
810 820 830 840 850
FEIDNIVAAG WNKEIGSQFS SESINNDKTF YTSNGLELIE RNYKSLFNDT
860 870 880 890 900
TEFNMIAGNY YPVINTIQIL DNKSKKQLTI LTKQSFGASS QNNGELNLLF
910 920 930 940 950
IRRSTDQFVT LNETMNDISN PLIKIKVLFG NSNSIENIRT PHSLLLENPL
960 970 980 990 1000
LPIYSIVSDI TIDKWISIYN TVFKPFKTSL PYNLHLLTFT KQQQQQQQDF
1010 1020 1030 1040 1050
NEDNPLDYFI RFLNIYEISQ SESFSQPIEF KLTNYFNNFN ITNIRESSLT
1060 1070
FNSIINNNTN SIILNPLNLI SLIITISKN
Length:1,079
Mass (Da):124,433
Last modified:May 24, 2005 - v1
Checksum:iAFD4C59A88DDC0C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000004 Genomic DNA. Translation: EAL73086.1.
RefSeqiXP_646960.1. XM_641868.1.

Genome annotation databases

EnsemblProtistsiDDB0231613; DDB0231613; DDB_G0268994.
GeneIDi8616650.
KEGGiddi:DDB_G0268994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000004 Genomic DNA. Translation: EAL73086.1.
RefSeqiXP_646960.1. XM_641868.1.

3D structure databases

ProteinModelPortaliQ55ER0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0231613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231613; DDB0231613; DDB_G0268994.
GeneIDi8616650.
KEGGiddi:DDB_G0268994.

Organism-specific databases

dictyBaseiDDB_G0268994. manC.

Phylogenomic databases

eggNOGiCOG0383.
InParanoidiQ55ER0.
OMAiSCNNTII.
PhylomeDBiQ55ER0.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 2 hits.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 2 hits.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMANC_DICDI
AccessioniPrimary (citable) accession number: Q55ER0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.