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Q55ER0

- MANC_DICDI

UniProt

Q55ER0 - MANC_DICDI

Protein

Alpha-mannosidase C

Gene

manC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi44 – 441ZincBy similarity
    Metal bindingi46 – 461ZincBy similarity
    Active sitei158 – 1581NucleophileBy similarity
    Metal bindingi158 – 1581ZincBy similarity
    Metal bindingi475 – 4751ZincBy similarity

    GO - Molecular functioni

    1. alpha-mannosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_221646. Reactions specific to the complex N-glycan synthesis pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-mannosidase C (EC:3.2.1.24)
    Gene namesi
    Name:manC
    ORF Names:DDB_G0268994
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0268994. manC.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 10791057Alpha-mannosidase CPRO_0000327842Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi760 – 7601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi769 – 7691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi872 – 8721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi912 – 9121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1040 – 10401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1057 – 10571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231613.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55ER0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi357 – 3648Poly-Thr
    Compositional biasi437 – 4415Poly-Asn
    Compositional biasi442 – 4509Poly-Asp
    Compositional biasi648 – 66922Ser-richAdd
    BLAST
    Compositional biasi754 – 78431Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 38 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0383.
    OMAiSCNNTII.
    PhylomeDBiQ55ER0.

    Family and domain databases

    Gene3Di1.20.1270.50. 1 hit.
    2.60.40.1180. 2 hits.
    3.20.110.10. 1 hit.
    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR013780. Glyco_hydro_13_b.
    IPR027291. Glyco_hydro_38/57_N.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view]
    PfamiPF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    [Graphical view]
    SMARTiSM00872. Alpha-mann_mid. 1 hit.
    [Graphical view]
    SUPFAMiSSF74650. SSF74650. 2 hits.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q55ER0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFYKTFGFLF IYLIILISGT LSQKEIDSSN EQPVIEVFLV PHSHCDVGWL     50
    KTVEQYYTEN VTLILNNVIE TLTKDKSKKF NWAEIIYFER WWNDQNETLQ 100
    NQVKQLISNK QFYFVGGGWT QNDEAITDYQ AVINQMTLGH QFLFNQFGIK 150
    PEIGWQIDPF GPSTLTPTLF KLMGFKYHVI NRIDERIKYI FNATEMNIPE 200
    SGIMTIEREF EFLWYPSSNN PNISIFTHVL DHHYESPSLT IVDYEIPNLT 250
    YTSGFDFEGN PKINPPITIL NLRFRADLLV KIIKERIDLF RHNNLLLPFG 300
    GDFRFQDSKI EFNNMDKLIK FINSNQKTYG VNIKYSTVDE YFEKVIQDTN 350
    INWKEDTTTT TTTTIPIGGD EFPKLSNLDY FDYTKCDYND YQKYKTCSLY 400
    YSGFFSSYSE LKQISRQSDS LLRIGEFLYS FANLISNNNN NDDDDDDDND 450
    FNIQLKEISN ILVQHRNVSG ILTHHDAITG TAKTKVRDDY LLMLNQVQSN 500
    TMNNVIPNIV GYLLSNKSIQ NFDYSCNNTI IMNSPQIGDI FSISFTNSLG 550
    WDRSEYIQIQ LPPSTIVTVY NYNLISIQSQ IVQRFDKDNQ TFLYFNVETP 600
    SLGISTYFII ITSTNDDNVD DDVDKVFGDD ELLIYLLKNG ILSKPILSEI 650
    SEISELSSSS SSSSSSSSSQ ITIGNSKFNL NFNYLNENYN LLTLTSFDDL 700
    IENEYSIPIT QNYIEYISGN DNSYIFKPSG LPVNLKPESP KFYKVTGSLV 750
    QMITILYTNN CSQTYIVYNS TTTTTTTTTT TTTTNNDDSP PLELINDEQY 800
    FEIDNIVAAG WNKEIGSQFS SESINNDKTF YTSNGLELIE RNYKSLFNDT 850
    TEFNMIAGNY YPVINTIQIL DNKSKKQLTI LTKQSFGASS QNNGELNLLF 900
    IRRSTDQFVT LNETMNDISN PLIKIKVLFG NSNSIENIRT PHSLLLENPL 950
    LPIYSIVSDI TIDKWISIYN TVFKPFKTSL PYNLHLLTFT KQQQQQQQDF 1000
    NEDNPLDYFI RFLNIYEISQ SESFSQPIEF KLTNYFNNFN ITNIRESSLT 1050
    FNSIINNNTN SIILNPLNLI SLIITISKN 1079
    Length:1,079
    Mass (Da):124,433
    Last modified:May 24, 2005 - v1
    Checksum:iAFD4C59A88DDC0C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000004 Genomic DNA. Translation: EAL73086.1.
    RefSeqiXP_646960.1. XM_641868.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231613; DDB0231613; DDB_G0268994.
    GeneIDi8616650.
    KEGGiddi:DDB_G0268994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000004 Genomic DNA. Translation: EAL73086.1 .
    RefSeqi XP_646960.1. XM_641868.1.

    3D structure databases

    ProteinModelPortali Q55ER0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231613.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231613 ; DDB0231613 ; DDB_G0268994 .
    GeneIDi 8616650.
    KEGGi ddi:DDB_G0268994.

    Organism-specific databases

    dictyBasei DDB_G0268994. manC.

    Phylogenomic databases

    eggNOGi COG0383.
    OMAi SCNNTII.
    PhylomeDBi Q55ER0.

    Enzyme and pathway databases

    Reactomei REACT_221646. Reactions specific to the complex N-glycan synthesis pathway.

    Family and domain databases

    Gene3Di 1.20.1270.50. 1 hit.
    2.60.40.1180. 2 hits.
    3.20.110.10. 1 hit.
    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR013780. Glyco_hydro_13_b.
    IPR027291. Glyco_hydro_38/57_N.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view ]
    Pfami PF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    [Graphical view ]
    SMARTi SM00872. Alpha-mann_mid. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74650. SSF74650. 2 hits.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiMANC_DICDI
    AccessioniPrimary (citable) accession number: Q55ER0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3