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Q55ER0 (MANC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-mannosidase C

EC=3.2.1.24
Gene names
Name:manC
ORF Names:DDB_G0268994
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1079 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 38 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalpha-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 10791057Alpha-mannosidase C
PRO_0000327842

Regions

Compositional bias357 – 3648Poly-Thr
Compositional bias437 – 4415Poly-Asn
Compositional bias442 – 4509Poly-Asp
Compositional bias648 – 66922Ser-rich
Compositional bias754 – 78431Thr-rich

Sites

Active site1581Nucleophile By similarity
Metal binding441Zinc By similarity
Metal binding461Zinc By similarity
Metal binding1581Zinc By similarity
Metal binding4751Zinc By similarity

Amino acid modifications

Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation4671N-linked (GlcNAc...) Potential
Glycosylation5161N-linked (GlcNAc...) Potential
Glycosylation5271N-linked (GlcNAc...) Potential
Glycosylation5891N-linked (GlcNAc...) Potential
Glycosylation7601N-linked (GlcNAc...) Potential
Glycosylation7691N-linked (GlcNAc...) Potential
Glycosylation8481N-linked (GlcNAc...) Potential
Glycosylation8721N-linked (GlcNAc...) Potential
Glycosylation9121N-linked (GlcNAc...) Potential
Glycosylation10401N-linked (GlcNAc...) Potential
Glycosylation10571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q55ER0 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: AFD4C59A88DDC0C4

FASTA1,079124,433
        10         20         30         40         50         60 
MFYKTFGFLF IYLIILISGT LSQKEIDSSN EQPVIEVFLV PHSHCDVGWL KTVEQYYTEN 

        70         80         90        100        110        120 
VTLILNNVIE TLTKDKSKKF NWAEIIYFER WWNDQNETLQ NQVKQLISNK QFYFVGGGWT 

       130        140        150        160        170        180 
QNDEAITDYQ AVINQMTLGH QFLFNQFGIK PEIGWQIDPF GPSTLTPTLF KLMGFKYHVI 

       190        200        210        220        230        240 
NRIDERIKYI FNATEMNIPE SGIMTIEREF EFLWYPSSNN PNISIFTHVL DHHYESPSLT 

       250        260        270        280        290        300 
IVDYEIPNLT YTSGFDFEGN PKINPPITIL NLRFRADLLV KIIKERIDLF RHNNLLLPFG 

       310        320        330        340        350        360 
GDFRFQDSKI EFNNMDKLIK FINSNQKTYG VNIKYSTVDE YFEKVIQDTN INWKEDTTTT 

       370        380        390        400        410        420 
TTTTIPIGGD EFPKLSNLDY FDYTKCDYND YQKYKTCSLY YSGFFSSYSE LKQISRQSDS 

       430        440        450        460        470        480 
LLRIGEFLYS FANLISNNNN NDDDDDDDND FNIQLKEISN ILVQHRNVSG ILTHHDAITG 

       490        500        510        520        530        540 
TAKTKVRDDY LLMLNQVQSN TMNNVIPNIV GYLLSNKSIQ NFDYSCNNTI IMNSPQIGDI 

       550        560        570        580        590        600 
FSISFTNSLG WDRSEYIQIQ LPPSTIVTVY NYNLISIQSQ IVQRFDKDNQ TFLYFNVETP 

       610        620        630        640        650        660 
SLGISTYFII ITSTNDDNVD DDVDKVFGDD ELLIYLLKNG ILSKPILSEI SEISELSSSS 

       670        680        690        700        710        720 
SSSSSSSSSQ ITIGNSKFNL NFNYLNENYN LLTLTSFDDL IENEYSIPIT QNYIEYISGN 

       730        740        750        760        770        780 
DNSYIFKPSG LPVNLKPESP KFYKVTGSLV QMITILYTNN CSQTYIVYNS TTTTTTTTTT 

       790        800        810        820        830        840 
TTTTNNDDSP PLELINDEQY FEIDNIVAAG WNKEIGSQFS SESINNDKTF YTSNGLELIE 

       850        860        870        880        890        900 
RNYKSLFNDT TEFNMIAGNY YPVINTIQIL DNKSKKQLTI LTKQSFGASS QNNGELNLLF 

       910        920        930        940        950        960 
IRRSTDQFVT LNETMNDISN PLIKIKVLFG NSNSIENIRT PHSLLLENPL LPIYSIVSDI 

       970        980        990       1000       1010       1020 
TIDKWISIYN TVFKPFKTSL PYNLHLLTFT KQQQQQQQDF NEDNPLDYFI RFLNIYEISQ 

      1030       1040       1050       1060       1070 
SESFSQPIEF KLTNYFNNFN ITNIRESSLT FNSIINNNTN SIILNPLNLI SLIITISKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000004 Genomic DNA. Translation: EAL73086.1.
RefSeqXP_646960.1. XM_641868.1.

3D structure databases

ProteinModelPortalQ55ER0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231613.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231613; DDB0231613; DDB_G0268994.
GeneID8616650.
KEGGddi:DDB_G0268994.

Organism-specific databases

dictyBaseDDB_G0268994. manC.

Phylogenomic databases

eggNOGCOG0383.
OMASCNNTII.
PhylomeDBQ55ER0.

Family and domain databases

Gene3D1.20.1270.50. 1 hit.
2.60.40.1180. 2 hits.
3.20.110.10. 1 hit.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
[Graphical view]
SMARTSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMSSF74650. SSF74650. 2 hits.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANC_DICDI
AccessionPrimary (citable) accession number: Q55ER0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase