Q55EI0 (ATE1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginyl-tRNA--protein transferase 1
Short name=Arginyltransferase 1
Short name=R-transferase 1
EC=2.3.2.8

Alternative name(s):
Arginine-tRNA--protein transferase 1

Gene names

Name:	ate1
ORF Names:	DDB_G0269024

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues By similarity.
Catalytic activity	L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.
Sequence similarities	Belongs to the R-transferase family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein arginylation Inferred from electronic annotation. Source: InterPro
Molecular function	arginyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	Arginyl-tRNA--protein transferase 1		PRO_0000351082
Regions
	Compositional bias	137 – 280	144	Asn-rich
	Compositional bias	266 – 295	30	Thr-rich
	Compositional bias	354 – 398	45	Asp-rich
	Compositional bias	562 – 567	6	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q55EI0 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 9118972C8AA2F55F	FASTA	629	73,820
	10 20 30 40 50 60 MERFLMQSSL STSSLIYPHG SYDSSCNYCD AGEDKKGRIC YGMVADQLTC EDYQLLIDQG 70 80 90 100 110 120 WRRSGTFLYK PNNSDKKTCC PQYTIRLDTS SFKPSKDNKS TIKKFNNYIL NNIIKEKDSS 130 140 150 160 170 180 TTSTTKDIIN TTQIKSNTKN NNNKTNDENI IKLNNDIIEI ILNNEFINKF NEQDKKILKE 190 200 210 220 230 240 NLKIKINSNK MIKETGSYSL SFGIFNKYRS ELNQHSITID QIINFTILEF NKTINNSDYQ 250 260 270 280 290 300 FNLEKGQNNH INFKMINSSQ ILNDSTKTKT LNIQNNSNKN STTTATTATT TTTTTNEPKH 310 320 330 340 350 360 KFEISIHKPK CTDEVFSLYC KYQKIIHKED DEKTKSGFKR FLVDSPLIPI IHPDESYDDY 370 380 390 400 410 420 VYDGKDDDDD DDDKDEKEDD EDEDQEDDED EDDGNNEDEK KITKENKEKE IKNHIYKIGK 430 440 450 460 470 480 KSKTLKTRKF GEIKTPKPGY GSFHQYYRLD GKLVGVGVID ILPECLSSVY FFYDPDFNFL 490 500 510 520 530 540 SLGKYSALNE IEWVQKVSQS IPQLKYYYMG YYIHSCQKMK YKANYQPSQL LCLETFKWVE 550 560 570 580 590 600 FKKAISFLQP DKKYSRFYFD ENENNNNEKL TYFEKEPELL ERVKFRQKNF TFHFSDVSVR 610 620 FQNLLKDQVI DYINHVGPEL TKELIFYFK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000004 Genomic DNA. Translation: EAL73101.1.
RefSeq	XP_647040.1. XM_641948.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0238346; DDB0238346; DDB_G0269024.
GeneID	8616735.
GenomeReviews	Gene locus ate1 in contig CM000150_GR.
KEGG	ddi:DDB_G0269024.
Organism-specific databases
dictyBase	DDB_G0269024. ate1.
Phylogenomic databases
eggNOG	KOG1193.
GeneTree	EPrGT00050000002398.
OMA	SICASAF.
PhylomeDB	Q55EI0.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR017137. Arg-tRNA-P_Trfase_1_euk. IPR007472. Arg-tRNA-P_Trfase_C. IPR007471. Arg_tRNA_PTrfase_N. [Graphical view]
KO	K00685.
Pfam	PF04377. ATE_C. 1 hit. PF04376. ATE_N. 1 hit. [Graphical view]
PIRSF	PIRSF037207. ATE1_euk. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ATE1_DICDI

Accession

Primary (citable) accession number: Q55EI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)