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Q55E72

- PKS1_DICDI

UniProt

Q55E72 - PKS1_DICDI

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Protein

Probable polyketide synthase 1

Gene

stlA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable polyketide synthase By similarity. Produces only acylpyrones; in vitro.By similarity1 Publication

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Cofactori

Binds 1 phosphopantetheine covalently.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei180 – 1801For beta-ketoacyl synthase activityPROSITE-ProRule annotation
Active sitei682 – 6821For acyl/malonyl transferase activityPROSITE-ProRule annotation
Active sitei2930 – 29301PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
  2. polyketide biosynthetic process Source: dictyBase
  3. resorcinol metabolic process Source: dictyBase
  4. sorocarp spore cell differentiation Source: dictyBase
  5. sorocarp stalk cell differentiation Source: dictyBase
  6. sorus development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable polyketide synthase 1
Short name:
dipks1
Including the following 2 domains:
Polyketide synthase stlA (EC:2.3.1.-)
Chalcone synthase stlA (EC:2.3.1.74)
Alternative name(s):
Steely1
Gene namesi
Name:stlA
Synonyms:pks1
ORF Names:DDB_G0269364
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269364. stlA.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31473147Probable polyketide synthase 1PRO_0000377901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2605 – 26051O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiQ55E72.

Expressioni

Developmental stagei

Expressed during development. Expressed maximally in early development before cellular aggregation.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0190208.

Structurei

Secondary structure

1
3147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2788 – 27958
Beta strandi2797 – 27993
Helixi2803 – 281311
Helixi2818 – 282912
Helixi2845 – 28473
Helixi2849 – 28546
Helixi2857 – 288327
Helixi2887 – 28893
Beta strandi2892 – 28998
Helixi2906 – 29149
Beta strandi2921 – 29277
Helixi2929 – 29313
Helixi2932 – 294413
Beta strandi2951 – 29588
Helixi2961 – 29633
Beta strandi2967 – 29693
Helixi2970 – 29789
Beta strandi2982 – 299110
Beta strandi3000 – 300910
Beta strandi3016 – 30227
Beta strandi3025 – 30306
Helixi3034 – 305320
Turni3054 – 30563
Beta strandi3063 – 30708
Helixi3075 – 308410
Helixi3089 – 30924
Helixi3093 – 310210
Helixi3108 – 311811
Beta strandi3125 – 31339
Turni3134 – 31363
Beta strandi3137 – 31459

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H84X-ray2.90A/B2776-3147[»]
ProteinModelPortaliQ55E72.
SMRiQ55E72. Positions 2785-3147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ55E72.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2573 – 264270Acyl carrierPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 21454Beta-ketoacyl synthaseAdd
BLAST
Regioni672 – 70534Acyl/malonyl transferaseAdd
BLAST
Regioni2789 – 3147359Chalcone synthaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi355 – 3628Poly-Asp
Compositional biasi470 – 4789Poly-Asn
Compositional biasi561 – 5644Poly-Ser
Compositional biasi576 – 5816Poly-Thr
Compositional biasi1684 – 16885Poly-Ser
Compositional biasi2097 – 21004Poly-Gln
Compositional biasi2647 – 26559Poly-Asn
Compositional biasi2770 – 27745Poly-Gln

Domaini

Modular protein possessing six classical catalytic domains and a type III polyketide synthase domain. May facilitate covalent transfer of steely N-terminal acyl products directly to the C-terminal type III PKS active sites, which catalyze both iterative polyketide extension and cyclization.

Sequence similaritiesi

In the C-terminal section; belongs to the chalcone/stilbene synthases family.Curated
Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3424.
InParanoidiQ55E72.
OMAiNDDSINH.
PhylomeDBiQ55E72.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 4 hits.
3.40.50.150. 1 hit.
3.40.50.720. 2 hits.
3.90.180.10. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013154. ADH_GroES-like.
IPR012328. Chalcone/stilbene_synth_C.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR013217. Methyltransf_12.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR029063. SAM-dependent_MTases-like.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08240. ADH_N. 1 hit.
PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF53901. SSF53901. 5 hits.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55E72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKNSKIQSP NSSDVAVIGV GFRFPGNSND PESLWNNLLD GFDAITQVPK
60 70 80 90 100
ERWATSFREM GLIKNKFGGF LKDSEWKNFD PLFFGIGPKE APFIDPQQRL
110 120 130 140 150
LLSIVWESLE DAYIRPDELR GSNTGVFIGV SNNDYTKLGF QDNYSISPYT
160 170 180 190 200
MTGSNSSLNS NRISYCFDFR GPSITVDTAC SSSLVSVNLG VQSIQMGECK
210 220 230 240 250
IAICGGVNAL FDPSTSVAFS KLGVLSENGR CNSFSDQASG YVRSEGAGVV
260 270 280 290 300
VLKSLEQAKL DGDRIYGVIK GVSSNEDGAS NGDKNSLTTP SCEAQSINIS
310 320 330 340 350
KAMEKASLSP SDIYYIEAHG TGTPVGDPIE VKALSKIFSN SNNNQLNNFS
360 370 380 390 400
TDGNDNDDDD DDNTSPEPLL IGSFKSNIGH LESAAGIASL IKCCLMLKNR
410 420 430 440 450
MLVPSINCSN LNPSIPFDQY NISVIREIRQ FPTDKLVNIG INSFGFGGSN
460 470 480 490 500
CHLIIQEYNN NFKNNSTICN NNNNNNNNID YLIPISSKTK KSLDKYLILI
510 520 530 540 550
KTNSNYHKDI SFDDFVKFQI KSKQYNLSNR MTTIANDWNS FIKGSNEFHN
560 570 580 590 600
LIESKDGEGG SSSSNRGIDS ANQINTTTTS TINDIEPLLV FVFCGQGPQW
610 620 630 640 650
NGMIKTLYNS ENVFKNTVDH VDSILYKYFG YSILNVLSKI DDNDDSINHP
660 670 680 690 700
IVAQPSLFLL QIGLVELFKY WGIYPSISVG HSFGEVSSYY LSGIISLETA
710 720 730 740 750
CKIVYVRSSN QNKTMGSGKM LVVSMGFKQW NDQFSAEWSD IEIACYNAPD
760 770 780 790 800
SIVVTGNEER LKELSIKLSD ESNQIFNTFL RSPCSFHSSH QEVIKGSMFE
810 820 830 840 850
ELSNLQSTGE TEIPLFSTVT GRQVLSGHVT AQHIYDNVRE PVLFQKTIES
860 870 880 890 900
ITSYIKSHYP SNQKVIYVEI APHPTLFSLI KKSIPSSNKN SSSVLCPLNR
910 920 930 940 950
KENSNNSYKK FVSQLYFNGV NVDFNFQLNS ICDNVNNDHH LNNVKQNSFK
960 970 980 990 1000
ETTNSLPRYQ WEQDEYWSEP LISRKNRLEG PTTSLLGHRI IYSFPVFQSV
1010 1020 1030 1040 1050
LDLQSDNYKY LLDHLVNGKP VFPGAGYLDI IIEFFDYQKQ QLNSSDSSNS
1060 1070 1080 1090 1100
YIINVDKIQF LNPIHLTENK LQTLQSSFEP IVTKKSAFSV NFFIKDTVED
1110 1120 1130 1140 1150
QSKVKSMSDE TWTNTCKATI SLEQQQPSPS STLTLSKKQD LQILRNRCDI
1160 1170 1180 1190 1200
SKLDKFELYD KISKNLGLQY NSLFQVVDTI ETGKDCSFAT LSLPEDTLFT
1210 1220 1230 1240 1250
TILNPCLLDN CFHGLLTLIN EKGSFVVESI SSVSIYLENI GSFNQTSVGN
1260 1270 1280 1290 1300
VQFYLYTTIS KATSFSSEGT CKLFTKDGSL ILSIGKFIIK STNPKSTKTN
1310 1320 1330 1340 1350
ETIESPLDET FSIEWQSKDS PIPTPQQIQQ QSPLNSNPSF IRSTILKDIQ
1360 1370 1380 1390 1400
FEQYCSSIIH KELINHEKYK NQQSFDINSL ENHLNDDQLM ESLSISKEYL
1410 1420 1430 1440 1450
RFFTRIISII KQYPKILNEK ELKELKEIIE LKYPSEVQLL EFEVIEKVSM
1460 1470 1480 1490 1500
IIPKLLFEND KQSSMTLFQD NLLTRFYSNS NSTRFYLERV SEMVLESIRP
1510 1520 1530 1540 1550
IVREKRVFRI LEIGAGTGSL SNVVLTKLNT YLSTLNSNGG SGYNIIIEYT
1560 1570 1580 1590 1600
FTDISANFII GEIQETMCNL YPNVTFKFSV LDLEKEIINS SDFLMGDYDI
1610 1620 1630 1640 1650
VLMAYVIHAV SNIKFSIEQL YKLLSPRGWL LCIEPKSNVV FSDLVFGCFN
1660 1670 1680 1690 1700
QWWNYYDDIR TTHCSLSESQ WNQLLLNQSL NNESSSSSNC YGGFSNVSFI
1710 1720 1730 1740 1750
GGEKDVDSHS FILHCQKESI SQMKLATTIN NGLSSGSIVI VLNSQQLTNM
1760 1770 1780 1790 1800
KSYPKVIEYI QEATSLCKTI EIIDSKDVLN STNSVLEKIQ KSLLVFCLLG
1810 1820 1830 1840 1850
YDLLENNYQE QSFEYVKLLN LISTTASSSN DKKPPKVLLI TKQSERISRS
1860 1870 1880 1890 1900
FYSRSLIGIS RTSMNEYPNL SITSIDLDTN DYSLQSLLKP IFSNSKFSDN
1910 1920 1930 1940 1950
EFIFKKGLMF VSRIFKNKQL LESSNAFETD SSNLYCKASS DLSYKYAIKQ
1960 1970 1980 1990 2000
SMLTENQIEI KVECVGINFK DNLFYKGLLP QEIFRMGDIY NPPYGLECSG
2010 2020 2030 2040 2050
VITRIGSNVT EYSVGQNVFG FARHSLGSHV VTNKDLVILK PDTISFSEAA
2060 2070 2080 2090 2100
SIPVVYCTAW YSLFNIGQLS NEESILIHSA TGGVGLASLN LLKMKNQQQQ
2110 2120 2130 2140 2150
PLTNVYATVG SNEKKKFLID NFNNLFKEDG ENIFSTRDKE YSNQLESKID
2160 2170 2180 2190 2200
VILNTLSGEF VESNFKSLRS FGRLIDLSAT HVYANQQIGL GNFKFDHLYS
2210 2220 2230 2240 2250
AVDLERLIDE KPKLLQSILQ RITNSIVNGS LEKIPITIFP STETKDAIEL
2260 2270 2280 2290 2300
LSKRSHIGKV VVDCTDISKC NPVGDVITNF SMRLPKPNYQ LNLNSTLLIT
2310 2320 2330 2340 2350
GQSGLSIPLL NWLLSKSGGN VKNVVIISKS TMKWKLQTMI SHFVSGFGIH
2360 2370 2380 2390 2400
FNYVQVDISN YDALSEAIKQ LPSDLPPITS VFHLAAIYND VPMDQVTMST
2410 2420 2430 2440 2450
VESVHNPKVL GAVNLHRISV SFGWKLNHFV LFSSITAITG YPDQSIYNSA
2460 2470 2480 2490 2500
NSILDALSNF RRFMGLPSFS INLGPMKDEG KVSTNKSIKK LFKSRGLPSL
2510 2520 2530 2540 2550
SLNKLFGLLE VVINNPSNHV IPSQLICSPI DFKTYIESFS TMRPKLLHLQ
2560 2570 2580 2590 2600
PTISKQQSSI INDSTKASSN ISLQDKITSK VSDLLSIPIS KINFDHPLKH
2610 2620 2630 2640 2650
YGLDSLLTVQ FKSWIDKEFE KNLFTHIQLA TISINSFLEK VNGLSTNNNN
2660 2670 2680 2690 2700
NNNSNVKSSP SIVKEEIVTL DKDQQPLLLK EHQHIIISPD IRINKPKRES
2710 2720 2730 2740 2750
LIRTPILNKF NQITESIITP STPSLSQSDV LKTPPIKSLN NTKNSSLINT
2760 2770 2780 2790 2800
PPIQSVQQHQ KQQQKVQVIQ QQQQPLSRLS YKSNNNSFVL GIGISVPGEP
2810 2820 2830 2840 2850
ISQQSLKDSI SNDFSDKAET NEKVKRIFEQ SQIKTRHLVR DYTKPENSIK
2860 2870 2880 2890 2900
FRHLETITDV NNQFKKVVPD LAQQACLRAL KDWGGDKGDI THIVSVTSTG
2910 2920 2930 2940 2950
IIIPDVNFKL IDLLGLNKDV ERVSLNLMGC LAGLSSLRTA ASLAKASPRN
2960 2970 2980 2990 3000
RILVVCTEVC SLHFSNTDGG DQMVASSIFA DGSAAYIIGC NPRIEETPLY
3010 3020 3030 3040 3050
EVMCSINRSF PNTENAMVWD LEKEGWNLGL DASIPIVIGS GIEAFVDTLL
3060 3070 3080 3090 3100
DKAKLQTSTA ISAKDCEFLI HTGGKSILMN IENSLGIDPK QTKNTWDVYH
3110 3120 3130 3140
AYGNMSSASV IFVMDHARKS KSLPTYSISL AFGPGLAFEG CFLKNVV
Length:3,147
Mass (Da):352,195
Last modified:May 24, 2005 - v1
Checksum:i6B67391AB6596F46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72032.1.
RefSeqiXP_645909.1. XM_640817.1.

Genome annotation databases

EnsemblProtistsiDDB0234164; DDB0234164; DDB_G0269364.
GeneIDi8616850.
KEGGiddi:DDB_G0269364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72032.1 .
RefSeqi XP_645909.1. XM_640817.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2H84 X-ray 2.90 A/B 2776-3147 [» ]
ProteinModelPortali Q55E72.
SMRi Q55E72. Positions 2785-3147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0190208.

Proteomic databases

PRIDEi Q55E72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0234164 ; DDB0234164 ; DDB_G0269364 .
GeneIDi 8616850.
KEGGi ddi:DDB_G0269364.

Organism-specific databases

dictyBasei DDB_G0269364. stlA.

Phylogenomic databases

eggNOGi COG3424.
InParanoidi Q55E72.
OMAi NDDSINH.
PhylomeDBi Q55E72.

Enzyme and pathway databases

UniPathwayi UPA00154 .

Miscellaneous databases

EvolutionaryTracei Q55E72.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 4 hits.
3.40.50.150. 1 hit.
3.40.50.720. 2 hits.
3.90.180.10. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013154. ADH_GroES-like.
IPR012328. Chalcone/stilbene_synth_C.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR013217. Methyltransf_12.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR029063. SAM-dependent_MTases-like.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF08240. ADH_N. 1 hit.
PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
SMARTi SM00827. PKS_AT. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 1 hit.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF53901. SSF53901. 5 hits.
SSF55048. SSF55048. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Polyketide synthase genes and the natural products potential of Dictyostelium discoideum."
    Zucko J., Skunca N., Curk T., Zupan B., Long P.F., Cullum J., Kessin R.H., Hranueli D.
    Bioinformatics 23:2543-2549(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase."
    Austin M.B., Saito T., Bowman M.E., Haydock S., Kato A., Moore B.S., Kay R.R., Noel J.P.
    Nat. Chem. Biol. 2:494-502(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 2776-3147, FUNCTION, DEVELOPMENTAL STAGE, SUBUNIT.

Entry informationi

Entry nameiPKS1_DICDI
AccessioniPrimary (citable) accession number: Q55E72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 24, 2005
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

In reference to their hybrid nature and to their discovery in D.discoideum, authors term these type I FAS-type III PKS fusion enzymes 'steely'.1 Publication
Encoded by one of the numerous copies of polyketide synthase genes localized in chromosome 1.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3