UniProtKB - Q55E39 (DUSP1_DICDI)
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Protein
Probable dual specificity protein phosphatase DDB_G0269404
Gene
DDB_G0269404
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity
Catalytic activityi
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 113 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein tyrosine/serine/threonine phosphatase activity Source: InterPro
- protein tyrosine phosphatase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:DDB_G0269404 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Mycetozoa › Dictyostelids › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0269404. dspA. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332950 | 1 – 212 | Probable dual specificity protein phosphatase DDB_G0269404Add BLAST | 212 |
Structurei
3D structure databases
ProteinModelPortali | Q55E39. |
SMRi | Q55E39. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 168 | Tyrosine-protein phosphataseAdd BLAST | 138 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 16 | Poly-Gly | 4 | |
Compositional biasi | 176 – 187 | Poly-ThrAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated
Phylogenomic databases
InParanoidi | Q55E39. |
KOi | K14165. |
OMAi | LFIGNFK. |
PhylomeDBi | Q55E39. |
Family and domain databases
CDDi | cd00127. DSPc. 1 hit. |
Gene3Di | 3.90.190.10. 1 hit. |
InterProi | View protein in InterPro IPR000340. Dual-sp_phosphatase_cat-dom. IPR024950. DUSP. IPR029021. Prot-tyrosine_phosphatase-like. IPR016130. Tyr_Pase_AS. IPR000387. TYR_PHOSPHATASE_dom. IPR020422. TYR_PHOSPHATASE_DUAL_dom. |
PANTHERi | PTHR10159. PTHR10159. 1 hit. |
Pfami | View protein in Pfam PF00782. DSPc. 1 hit. |
SMARTi | View protein in SMART SM00195. DSPc. 1 hit. |
SUPFAMi | SSF52799. SSF52799. 1 hit. |
PROSITEi | View protein in PROSITE PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q55E39-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKNKDDEES YCGGGGYWDM VEDLEEEICF DAQEVIPNLY IGSISAATCT
60 70 80 90 100
TSLKEHKITH ILSISTNPPK IKEFTTLCIN IEDESQKDIS SYFQQCHGFI
110 120 130 140 150
ENGRKLGGIL VHCSAGVSRS ASVVISYLMS VFFKPFWYCM QYLRNIRPCI
160 170 180 190 200
QPNTGFINQL INYEATILKN QNVISTTTTT TTTTTITKKK LISNDCNNDD
210
NSSGGSGGGM ES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000005 Genomic DNA. Translation: EAL72052.1. |
RefSeqi | XP_645942.1. XM_640850.1. |
Genome annotation databases
EnsemblProtistsi | EAL72052; EAL72052; DDB_G0269404. |
GeneIDi | 8616886. |
KEGGi | ddi:DDB_G0269404. |
Similar proteinsi
Entry informationi
Entry namei | DUSP1_DICDI | |
Accessioni | Q55E39Primary (citable) accession number: Q55E39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | March 28, 2018 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |