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Q55E39 (DUSP1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dual specificity protein phosphatase DDB_G0269404

EC=3.1.3.16
EC=3.1.3.48
Gene names
ORF Names:DDB_G0269404
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Probable dual specificity protein phosphatase DDB_G0269404
PRO_0000332950

Regions

Domain31 – 168138Tyrosine-protein phosphatase
Compositional bias13 – 164Poly-Gly
Compositional bias176 – 18712Poly-Thr

Sites

Active site1131Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55E39 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: B85E14AB152EF34D

FASTA21223,476
        10         20         30         40         50         60 
MAKNKDDEES YCGGGGYWDM VEDLEEEICF DAQEVIPNLY IGSISAATCT TSLKEHKITH 

        70         80         90        100        110        120 
ILSISTNPPK IKEFTTLCIN IEDESQKDIS SYFQQCHGFI ENGRKLGGIL VHCSAGVSRS 

       130        140        150        160        170        180 
ASVVISYLMS VFFKPFWYCM QYLRNIRPCI QPNTGFINQL INYEATILKN QNVISTTTTT 

       190        200        210 
TTTTTITKKK LISNDCNNDD NSSGGSGGGM ES 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72052.1.

3D structure databases

ProteinModelPortalQ55E39.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGddi:DDB_G0269404.

Organism-specific databases

dictyBaseDDB_G0269404.

Phylogenomic databases

eggNOGCOG2453.
OMAVVISYLM.
PhylomeDBQ55E39.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUSP1_DICDI
AccessionPrimary (citable) accession number: Q55E39
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase