DDB_G0269404

Functionⁱ

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	113	Phosphocysteine intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

protein tyrosine/serine/threonine phosphatase activity Source: InterPro
protein tyrosine phosphatase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable dual specificity protein phosphatase DDB_G0269404 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesⁱ	ORF Names:DDB_G0269404
Organismⁱ	Dictyostelium discoideum (Slime mold)
Taxonomic identifierⁱ	44689 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyostelids › Dictyosteliales › Dictyosteliaceae › Dictyostelium
Proteomesⁱ	UP000002195 Componentsⁱ: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseⁱ	DDB_G0269404. dspA.

dictyBaseⁱ

DDB_G0269404. dspA.

Subcellular locationⁱ

GO - Cellular componentⁱ

microtubule organizing center
Source: dictyBase
Inferred from direct assayⁱ
- 28847951

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000332950	1 – 212	Probable dual specificity protein phosphatase DDB_G0269404Add BLAST		212

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q55E39.
SMRⁱ	Q55E39.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 168	Tyrosine-protein phosphataseAdd BLAST		138

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	13 – 16	Poly-Gly		4
Compositional biasⁱ	176 – 187	Poly-ThrAdd BLAST		12

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated

Phylogenomic databases

InParanoidⁱ	Q55E39.
KEGG Orthology (KO) More...KOⁱ	K14165.
OMAⁱ	LFIGNFK.
PhylomeDBⁱ	Q55E39.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00127. DSPc. 1 hit.
Gene3Dⁱ	3.90.190.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000340. Dual-sp_phosphatase_cat-dom. IPR024950. DUSP. IPR029021. Prot-tyrosine_phosphatase-like. IPR016130. Tyr_Pase_AS. IPR000387. TYR_PHOSPHATASE_dom. IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERⁱ	PTHR10159. PTHR10159. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00782. DSPc. 1 hit.
SMARTⁱ	View protein in SMART SM00195. DSPc. 1 hit.
SUPFAMⁱ	SSF52799. SSF52799. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q55E39-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKNKDDEES YCGGGGYWDM VEDLEEEICF DAQEVIPNLY IGSISAATCT 
        60         70         80         90        100
TSLKEHKITH ILSISTNPPK IKEFTTLCIN IEDESQKDIS SYFQQCHGFI 
       110        120        130        140        150
ENGRKLGGIL VHCSAGVSRS ASVVISYLMS VFFKPFWYCM QYLRNIRPCI 
       160        170        180        190        200
QPNTGFINQL INYEATILKN QNVISTTTTT TTTTTITKKK LISNDCNNDD 
       210 
NSSGGSGGGM ES

Length:212

Mass (Da):23,476

Last modified:May 24, 2005 - v1

Checksum:ⁱB85E14AB152EF34D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAFI02000005 Genomic DNA. Translation: EAL72052.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_645942.1. XM_640850.1.

Genome annotation databases

EnsemblProtistsⁱ	EAL72052; EAL72052; DDB_G0269404.
GeneIDⁱ	8616886.
KEGGⁱ	ddi:DDB_G0269404.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q55E39	D3BKD3 F4PYK9 UPI0006448580 A0A151Z3M7	Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500) (Heterostelium pallidum) Cavenderia fasciculata (strain SH3) (Slime mold) (Dictyostelium fasciculatum) Acytostelium subglobosum LB1 Tieghemostelium lacteum	212	UniRef50_Q55E39	Cluster: Probable dual specificity protein phosphatase DDB_G0269404	5

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAFI02000005 Genomic DNA. Translation: EAL72052.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_645942.1. XM_640850.1.

3D structure databases

ProteinModelPortalⁱ	Q55E39.
SMRⁱ	Q55E39.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblProtistsⁱ	EAL72052; EAL72052; DDB_G0269404.
GeneIDⁱ	8616886.
KEGGⁱ	ddi:DDB_G0269404.

Organism-specific databases

dictyBaseⁱ	DDB_G0269404. dspA.

dictyBaseⁱ

DDB_G0269404. dspA.

Phylogenomic databases

InParanoidⁱ	Q55E39.
KEGG Orthology (KO) More...KOⁱ	K14165.
OMAⁱ	LFIGNFK.
PhylomeDBⁱ	Q55E39.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q55E39.

PROⁱ

PR:Q55E39.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00127. DSPc. 1 hit.
Gene3Dⁱ	3.90.190.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000340. Dual-sp_phosphatase_cat-dom. IPR024950. DUSP. IPR029021. Prot-tyrosine_phosphatase-like. IPR016130. Tyr_Pase_AS. IPR000387. TYR_PHOSPHATASE_dom. IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERⁱ	PTHR10159. PTHR10159. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00782. DSPc. 1 hit.
SMARTⁱ	View protein in SMART SM00195. DSPc. 1 hit.
SUPFAMⁱ	SSF52799. SSF52799. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DUSP1_DICDI
Accessionⁱ	Q55E39Primary (citable) accession number: Q55E39
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
	Last sequence update:	May 24, 2005
	Last modified:	March 28, 2018
	This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - Q55E39 (DUSP1_DICDI)

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Probable dual specificity protein phosphatase DDB_G0269404

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Functionⁱ

Catalytic activityⁱ

Sites

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Compositional bias

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q55E39 (DUSP1_DICDI)

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Probable dual specificity protein phosphatase DDB_G0269404

DDB_G0269404

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ