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Reviewed, UniProtKB/Swiss-Prot Q55E34 (P5CR2_DICDI)

Last modified November 25, 2008. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Pyrroline-5-carboxylate reductase 2
      Short name=P5C reductase 2
      Short name=P5CR 2
    EC=1.5.1.2
Gene names
Name: pycr2
ORF Names: DDB_G0269410
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Subunit structure

Homodecamer; composed of 5 homodimers By similarity.

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords

   Biological processAmino-acid biosynthesis
Proline biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

proline biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

pyrroline-5-carboxylate reductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Pyrroline-5-carboxylate reductase 2
PRO_0000328305

Sequences

Sequence LengthMass (Da)Tools
Q55E34-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: FFE0C3E5B14122DD

FASTA29931,719
        10         20         30         40         50         60 
MVATDLKNNK NIAILGSGNL GVSIARGIVA SGHYKSNQIV LTRRTLEKIQ HLKDEEGFQI 

        70         80         90        100        110        120 
TSDNLEAANK CAILIIGVLP AQVPQLLESI KHLVTKDHII ISVVLGITIS GIRSHLQPDV 

       130        140        150        160        170        180 
YTPIVRAMPN TAIQYCESMT CIANKSDHPT KSGTAEQELA DQNALEVTEK IFNCCGECIT 

       190        200        210        220        230        240 
ISEEAMVSAP ALCSCGTAFF CRIIRAAASA GCEIGFHAED AVRIAAQTAK GAAIMLLKND 

       250        260        270        280        290 
SHPESEIDRI TTPSGATIAG LNTMEHNGLS SAIIKGIVMS AEKSSKSQAA LNKLNNVSS 

« Hide

Cross-references

Sequence databases

AAFI02000005 Genomic DNA. Translation: EAL72055.1.
RefSeqXP_645947.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3397085.
KEGGddi:DDB_0232207.

Organism-specific databases

dictyBaseDDB_G0269410. pycr2.

Family and domain databases

InterProIPR016040. NAD(P)-bd.
IPR004455. NADP_OxRdtase_F420.
IPR000304. P5CR.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11645. P5CR. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
PIRSFPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMsTIGR00112. proC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP5CR2_DICDI
AccessionPrimary (citable) accession number: Q55E34
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents