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Q55E34 (P5CR2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyrroline-5-carboxylate reductase 2

Short name=P5C reductase 2
Short name=P5CR 2
EC=1.5.1.2
Gene names
Name:pycr2
ORF Names:DDB_G0269410
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Subunit structure

Homodecamer; composed of 5 homodimers By similarity.

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Pyrroline-5-carboxylate reductase 2
PRO_0000328305

Sequences

Sequence LengthMass (Da)Tools
Q55E34 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: FFE0C3E5B14122DD

FASTA29931,719
        10         20         30         40         50         60 
MVATDLKNNK NIAILGSGNL GVSIARGIVA SGHYKSNQIV LTRRTLEKIQ HLKDEEGFQI 

        70         80         90        100        110        120 
TSDNLEAANK CAILIIGVLP AQVPQLLESI KHLVTKDHII ISVVLGITIS GIRSHLQPDV 

       130        140        150        160        170        180 
YTPIVRAMPN TAIQYCESMT CIANKSDHPT KSGTAEQELA DQNALEVTEK IFNCCGECIT 

       190        200        210        220        230        240 
ISEEAMVSAP ALCSCGTAFF CRIIRAAASA GCEIGFHAED AVRIAAQTAK GAAIMLLKND 

       250        260        270        280        290 
SHPESEIDRI TTPSGATIAG LNTMEHNGLS SAIIKGIVMS AEKSSKSQAA LNKLNNVSS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72055.1.
RefSeqXP_645947.1. XM_640855.1.

3D structure databases

ProteinModelPortalQ55E34.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ55E34.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0232207; DDB0232207; DDB_G0269410.
GeneID8616891.
GenomeReviewsGene locus pycr2 in contig CM000150_GR.
KEGGddi:DDB_G0269410.

Organism-specific databases

dictyBaseDDB_G0269410.

Phylogenomic databases

eggNOGKOG3124.
GeneTreeEPrGT00050000000673.
HOGENOMHBG726602.
OMATTHENTE.
PhylomeDBQ55E34.
ProtClustDBCLSZ2429861.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR004455. NADP_OxRdtase_F420.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11645. P5CR. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
PIRSFPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP5CR2_DICDI
AccessionPrimary (citable) accession number: Q55E34
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families