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Q55E06 (HEM2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Delta-aminolevulinic acid dehydratase

Short name=ALADH
EC=4.2.1.24
Alternative name(s):
Porphobilinogen synthase
Gene names
Name:alad
Synonyms:hemB
ORF Names:DDB_G0269444
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactor

Binds 1 zinc ion per monomer By similarity.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Subunit structure

Homooctamer By similarity.

Sequence similarities

Belongs to the ALADH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Delta-aminolevulinic acid dehydratase
PRO_0000328039

Sites

Active site2041Schiff-base intermediate with substrate By similarity
Active site2571Schiff-base intermediate with substrate By similarity
Metal binding1271Zinc; catalytic By similarity
Metal binding1291Zinc; catalytic By similarity
Metal binding1371Zinc; catalytic By similarity
Binding site2141Substrate 1 By similarity
Binding site2261Substrate 1 By similarity
Binding site2831Substrate 2 By similarity
Binding site3221Substrate 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55E06 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: 6ADA07F1C4933E5F

FASTA33336,744
        10         20         30         40         50         60 
MENNNKNYSH YLHSGYAHPI TRSWQGDKVI LKSQLIYPIF VTDLINTKTE IKSLPGQYQI 

        70         80         90        100        110        120 
SSDLVVEFLR PLVEKGLKSI ILFGVIISGV KDEQASSADK RESSPVIKSI ELIKNEFPEI 

       130        140        150        160        170        180 
LICTDLCLCA YTDHGHCGVL TEEGFIENEK SIIRLGEIAL SFAKAGAHVI APSDMMDCRV 

       190        200        210        220        230        240 
GQIKKVLFQN GYGGRVAVMA YSSKFASSYY GPFRDAAGSG AKHGDRQAYQ LPIASRGLGL 

       250        260        270        280        290        300 
RAALRDEAEG ADFIMVKPAG PYMDIIREVK DHVKVPVCCY QVSGEYAMIY HASVAGGIDL 

       310        320        330 
KSGVMESLIS LQRSGCDIFI TYFTPQLLDW LKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72072.2.

3D structure databases

ProteinModelPortalQ55E06.
SMRQ55E06. Positions 9-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231415.

Proteomic databases

PRIDEQ55E06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231415; DDB0231415; DDB_G0269444.
KEGGddi:DDB_G0269444.

Organism-specific databases

dictyBaseDDB_G0269444. hemB.

Phylogenomic databases

eggNOGCOG0113.
KOK01698.
OMAIITYFTP.
PhylomeDBQ55E06.
ProtClustDBCLSZ2432714.

Enzyme and pathway databases

UniPathwayUPA00251; UER00318.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERPTHR11458. PTHR11458. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
SMARTSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ55E06.

Entry information

Entry nameHEM2_DICDI
AccessionPrimary (citable) accession number: Q55E06
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase