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Protein

Tryptophan--tRNA ligase, cytoplasmic

Gene

trpS

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tryptophan-tRNA ligase activity Source: dictyBase

GO - Biological processi

  1. translation Source: dictyBase
  2. tryptophanyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, cytoplasmic (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
ORF Names:DDB_G0269454
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269454. trpS.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Tryptophan--tRNA ligase, cytoplasmicPRO_0000327792Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231245.

Structurei

3D structure databases

ProteinModelPortaliQ55DZ8.
SMRiQ55DZ8. Positions 28-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi95 – 10410"HIGH" region
Motifi281 – 2855"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
InParanoidiQ55DZ8.
KOiK01867.
OMAiKPETAIY.
PhylomeDBiQ55DZ8.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55DZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETTPTTNE TKEQVITPWE VEAAPGGSVD YMKLVDQFGS TVISEELIAR
60 70 80 90 100
FEKVTGKRAH HFLRRGIFFS HRDLKEILDH HESGKKWFLY TGRGPSSGSL
110 120 130 140 150
HFGHLLPFTF TKYLQDAFNV PLVVQMTNDE KFLWKDMTLE ESIKFTHNNV
160 170 180 190 200
KDIIALGFDI QKTFIFSNLE YIHHLYPNVL KIARCVNLNQ IQNIFGFKES
210 220 230 240 250
DAIGKFTFPP VQAAPCFPDS FPHIFPLNDP EIKNIRCLIP CAIDQDPYFR
260 270 280 290 300
MTRDIAHRIG HQKPALIHSK FFPALQGHNT KMSASDTNSA VYLSDTPDQV
310 320 330 340 350
KDKIKKHAFS GGGATKEEQE KNGADLSVDI TYEYLTFMLE DDEQLKDIAH
360 370 380 390 400
RYSTGKMMTG EIKQILIDLM NKIIIRHKEA RAKITDEVLS TFMSIRKLNF
Length:400
Mass (Da):45,850
Last modified:May 24, 2005 - v1
Checksum:i38FC775E37AE342C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72077.1.
RefSeqiXP_645983.1. XM_640891.1.

Genome annotation databases

EnsemblProtistsiDDB0231245; DDB0231245; DDB_G0269454.
GeneIDi8616928.
KEGGiddi:DDB_G0269454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72077.1.
RefSeqiXP_645983.1. XM_640891.1.

3D structure databases

ProteinModelPortaliQ55DZ8.
SMRiQ55DZ8. Positions 28-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0231245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231245; DDB0231245; DDB_G0269454.
GeneIDi8616928.
KEGGiddi:DDB_G0269454.

Organism-specific databases

dictyBaseiDDB_G0269454. trpS.

Phylogenomic databases

eggNOGiCOG0180.
InParanoidiQ55DZ8.
KOiK01867.
OMAiKPETAIY.
PhylomeDBiQ55DZ8.

Miscellaneous databases

PROiQ55DZ8.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSYWC_DICDI
AccessioniPrimary (citable) accession number: Q55DZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.