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Q55DZ8

- SYWC_DICDI

UniProt

Q55DZ8 - SYWC_DICDI

Protein

Tryptophan--tRNA ligase, cytoplasmic

Gene

trpS

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. tryptophan-tRNA ligase activity Source: dictyBase

    GO - Biological processi

    1. translation Source: dictyBase
    2. tryptophanyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase, cytoplasmic (EC:6.1.1.2)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:trpS
    ORF Names:DDB_G0269454
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0269454. trpS.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: dictyBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Tryptophan--tRNA ligase, cytoplasmicPRO_0000327792Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231245.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55DZ8.
    SMRiQ55DZ8. Positions 28-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi95 – 10410"HIGH" region
    Motifi281 – 2855"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiKTFIFNN.
    PhylomeDBiQ55DZ8.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55DZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTETTPTTNE TKEQVITPWE VEAAPGGSVD YMKLVDQFGS TVISEELIAR    50
    FEKVTGKRAH HFLRRGIFFS HRDLKEILDH HESGKKWFLY TGRGPSSGSL 100
    HFGHLLPFTF TKYLQDAFNV PLVVQMTNDE KFLWKDMTLE ESIKFTHNNV 150
    KDIIALGFDI QKTFIFSNLE YIHHLYPNVL KIARCVNLNQ IQNIFGFKES 200
    DAIGKFTFPP VQAAPCFPDS FPHIFPLNDP EIKNIRCLIP CAIDQDPYFR 250
    MTRDIAHRIG HQKPALIHSK FFPALQGHNT KMSASDTNSA VYLSDTPDQV 300
    KDKIKKHAFS GGGATKEEQE KNGADLSVDI TYEYLTFMLE DDEQLKDIAH 350
    RYSTGKMMTG EIKQILIDLM NKIIIRHKEA RAKITDEVLS TFMSIRKLNF 400
    Length:400
    Mass (Da):45,850
    Last modified:May 24, 2005 - v1
    Checksum:i38FC775E37AE342C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72077.1.
    RefSeqiXP_645983.1. XM_640891.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231245; DDB0231245; DDB_G0269454.
    GeneIDi8616928.
    KEGGiddi:DDB_G0269454.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72077.1 .
    RefSeqi XP_645983.1. XM_640891.1.

    3D structure databases

    ProteinModelPortali Q55DZ8.
    SMRi Q55DZ8. Positions 28-400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231245 ; DDB0231245 ; DDB_G0269454 .
    GeneIDi 8616928.
    KEGGi ddi:DDB_G0269454.

    Organism-specific databases

    dictyBasei DDB_G0269454. trpS.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi KTFIFNN.
    PhylomeDBi Q55DZ8.

    Miscellaneous databases

    PROi Q55DZ8.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiSYWC_DICDI
    AccessioniPrimary (citable) accession number: Q55DZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3