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Q55DY7

- PSB2_DICDI

UniProt

Q55DY7 - PSB2_DICDI

Protein

Proteasome subunit beta type-2

Gene

psmB2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. proteolysis Source: dictyBase
    2. proteolysis involved in cellular protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_217211. ER-Phagosome pathway.
    REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_221036. Separation of Sister Chromatids.
    REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
    REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

    Protein family/group databases

    MEROPSiT01.984.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit beta type-2 (EC:3.4.25.1)
    Gene namesi
    Name:psmB2
    ORF Names:DDB_G0269472
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0269472. psmB2.

    Subcellular locationi

    Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: dictyBase
    2. nucleus Source: dictyBase
    3. proteasome core complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Proteasome subunit beta type-2PRO_0000328130Add
    BLAST

    Proteomic databases

    PRIDEiQ55DY7.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0232958.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55DY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1B family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    KOiK02734.
    OMAiHFVRGEL.
    PhylomeDBiQ55DY7.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55DY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    METLLAFKVK GGVLCLADSS VNHSIVKMKD DEDKILEIDG HKLLLSAGEA    50
    GDRVQFTEYI SKNIKLYSLR NSYPMSTPAA ANFIRNELAT SIRSHPYSIN 100
    LILAGYDKEV EDGGTSLYYM DYLGSLQKLN FGCHGYASYF LLGLLDRHHK 150
    CDLSLEDGIN LMHLCTTELK TRFLVSGKYT LKFVSSEGIK VLPFNAPQ 198
    Length:198
    Mass (Da):22,110
    Last modified:May 24, 2005 - v1
    Checksum:i783749EF9ADEEB73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72086.1.
    RefSeqiXP_645994.1. XM_640902.1.

    Genome annotation databases

    EnsemblProtistsiDDB0232958; DDB0232958; DDB_G0269472.
    GeneIDi8616940.
    KEGGiddi:DDB_G0269472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72086.1 .
    RefSeqi XP_645994.1. XM_640902.1.

    3D structure databases

    ProteinModelPortali Q55DY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0232958.

    Protein family/group databases

    MEROPSi T01.984.

    Proteomic databases

    PRIDEi Q55DY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0232958 ; DDB0232958 ; DDB_G0269472 .
    GeneIDi 8616940.
    KEGGi ddi:DDB_G0269472.

    Organism-specific databases

    dictyBasei DDB_G0269472. psmB2.

    Phylogenomic databases

    eggNOGi COG0638.
    KOi K02734.
    OMAi HFVRGEL.
    PhylomeDBi Q55DY7.

    Enzyme and pathway databases

    Reactomei REACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_217211. ER-Phagosome pathway.
    REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_221036. Separation of Sister Chromatids.
    REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
    REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

    Miscellaneous databases

    PROi Q55DY7.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPSB2_DICDI
    AccessioniPrimary (citable) accession number: Q55DY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3